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  • Book
  • © 2017

Systems Genetics

Methods and Protocols

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1488)

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Table of contents (29 protocols)

  1. Front Matter

    Pages i-xiv
  2. Resources for Systems Genetics

    1. Front Matter

      Pages 1-1
    2. Resources for Systems Genetics

      • Robert W. Williams, Evan G. Williams
      Pages 3-29
    3. Heterogeneous Stock Populations for Analysis of Complex Traits

      • Leah C. Solberg Woods, Richard Mott
      Pages 31-44
  3. Tools for Analysis and Integration in Systems Genetics

    1. Front Matter

      Pages 45-45
    2. Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research

      • Janan T. Eppig, Cynthia L. Smith, Judith A. Blake, Martin Ringwald, James A. Kadin, Joel E. Richardson et al.
      Pages 47-73
    3. GeneNetwork: A Toolbox for Systems Genetics

      • Megan K. Mulligan, Khyobeni Mozhui, Pjotr Prins, Robert W. Williams
      Pages 75-120
    4. Integrative Functional Genomics for Systems Genetics in GeneWeaver.org

      • Jason A. Bubier, Michael A. Langston, Erich J. Baker, Elissa J. Chesler
      Pages 131-152
    5. Expression QTLs Mapping and Analysis: A Bayesian Perspective

      • Martha Imprialou, Enrico Petretto, Leonardo Bottolo
      Pages 189-215
    6. Epigenetics and Control of RNAs

      • Henrike Maatz, Sebastiaan van Heesch, Franziska Kreuchwig, Allison Faber, Eleonora Adami, Norbert Hubner et al.
      Pages 217-237
    7. RNA-Seq in the Collaborative Cross

      • Richard Green, Courtney Wilkins, Martin T. Ferris, Michael Gale Jr.
      Pages 251-263
    8. Visualization of Results from Systems Genetics Studies in Chromosomal Context

      • Karen Y. Oróstica, Ricardo A. Verdugo
      Pages 283-297
    9. Systems Genetics as a Tool to Identify Master Genetic Regulators in Complex Disease

      • Aida Moreno-Moral, Francesco Pesce, Jacques Behmoaras, Enrico Petretto
      Pages 337-362
  4. Systems Genetics Use Cases: Mapping and Combining Multiple Phenotypic Traits

    1. Front Matter

      Pages 363-363

About this book

This volume focuses on the use of system genetic methods and the use of murine models to study the role of gene variants and environmental factors on human health and disease—what is now often called personalized or precision health care. The protocols in this book will help readers analyze genetic causes of heritable variation across a wide range of systems and traits using rodent models. The chapters in this book are separated into three sections that cover: 1) resources for systems genetics; 2) tools for analysis and integration in systems genetics; and 3) systems genetics use cases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and tools, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls.

Practical and thorough, Systems Genetics: Methods and Protocols is a valuable resource for anyone who is interested in this diverse field.

Editors and Affiliations

  • Department of Infection Genetics, Helmholtz Centre for Infection Research & University of Veterinary Medicine Hannover, Braunschweig, Germany

    Klaus Schughart

  • Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, USA

    Robert W. Williams

Bibliographic Information

  • Book Title: Systems Genetics

  • Book Subtitle: Methods and Protocols

  • Editors: Klaus Schughart, Robert W. Williams

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-6427-7

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2017

  • Hardcover ISBN: 978-1-4939-6425-3Published: 08 December 2016

  • Softcover ISBN: 978-1-4939-8196-0Published: 06 July 2018

  • eBook ISBN: 978-1-4939-6427-7Published: 08 December 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 1

  • Number of Pages: XIV, 609

  • Number of Illustrations: 27 b/w illustrations, 137 illustrations in colour

  • Topics: Human Genetics

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access