Skip to main content
  • Book
  • © 2016

Molecular and Cellular Mechanobiology

  • Helps physiologists and biologists interested in mechanobiology but new to the field to understand the impact of mechanobiology on physiological regulation in health and disease
  • Details the roles of mechanobiology in the pathogenesis, diagnosis, treatment and prevention of disease
  • Covers basic principles in physiological conditions, as well as examples of clinical applications
  • Includes supplementary material: sn.pub/extras

Part of the book series: Physiology in Health and Disease (PIHD)

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

This is a preview of subscription content, log in via an institution to check for access.

Table of contents (13 chapters)

  1. Front Matter

    Pages i-xiii
  2. Mechanosensors

    1. Front Matter

      Pages 1-1
    2. Vascular Endothelial Mechanosensors in Response to Fluid Shear Stress

      • Li-Jing Chen, Wei-Li Wang, Jeng-Jiann Chiu
      Pages 29-56
    3. Cadherins in Mechanotransduction

      • D. E. Leckband
      Pages 57-80
  3. Transducers

    1. Front Matter

      Pages 81-81
    2. Emerging Roles of YAP/TAZ in Mechanobiology

      • Yubing Sun, Yue Shao, Xufeng Xue, Jianping Fu
      Pages 83-96
    3. Role of Rho GTPases in Mechanobiology

      • Christopher A. McCulloch
      Pages 97-117
  4. Epigenetic and Genetic Regulations in the Nucleus

    1. Front Matter

      Pages 141-141
    2. Perspectives of FRET Imaging to Study Epigenetics and Mechanobiology in the Nucleus

      • Qin Peng, Binbin Cheng, Shaoying Lu, Shu Chien, Yingxiao Wang
      Pages 143-161
    3. Mechanotransduction to Epigenetic Remodeling

      • Douglas Kelkhoff, Timothy Downing, Song Li
      Pages 163-173
    4. The Nuclear Lamina: From Mechanosensing in Differentiation to Cancer Cell Migration

      • Jerome Irianto, Irena L. Ivanovska, Joe Swift, Dennis E. Discher
      Pages 175-195
    5. Role of Cell Geometry on Nuclear Mechanics, Chromosome Reorganization, and Gene Expression

      • Yejun Wang, Ekta Makhija, Karthik Damodaran, G. V. Shivashankar
      Pages 197-216
  5. Applications

    1. Front Matter

      Pages 217-217
    2. Heart Valve Mechanobiology in Development and Disease

      • Aileen Zhong, Craig A. Simmons
      Pages 255-276
    3. Molecular and Cellular Mechanobiology of Cancer

      • Laurent Fattet, Jing Yang
      Pages 277-290
  6. Back Matter

    Pages 291-302

About this book

This book will cover the cutting-edge developments in molecular and cellular mechanobiology to date. Readers will have a clear understanding of mechanobiology at the molecular and cellular levels, encompassing the mechanosensors, transducers, and transcription. An integrative approach across different scales from molecular sensing to mechanotransduction and gene modulation for physiological regulation of cellular functions will be explored, as well as applications to pathophysiological states in disease. A comprehensive understanding of the roles of physicochemical microenvironment and intracellular responses in determining cellular function in health and disease will also be discussed.

Editors and Affiliations

  • Professor of Bioengineering and Medicine, University of California, San Diego, La Jolla, USA

    Shu Chien

  • Associate Professor of Bioengineering, University of California, San Diego, La Jolla, USA

    Adam J. Engler, Peter Yingxiao Wang

Bibliographic Information

Buy it now

Buying options

eBook USD 149.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access