Molecular Genetics of Axial Patterning, Growth and Disease in the Drosophila Eye

1. Front Matter

   Pages i-xiv

   PDF

2. Early Eye Development: Specification and Determination

   • Emmi Bürgy-Roukala, Sara Miellet, Abhishek K. Mishra, Simon G. Sprecher

   Pages 1-36

3. Molecular Genetic Mechanisms of Axial Patterning: Mechanistic Insights into Generation of Axes in the Developing Eye

   • Meghana Tare, Oorvashi Roy Puli, Amit Singh

   Pages 37-73

4. Catching the Next Wave: Patterning of the Drosophila Eye by the Morphogenetic Furrow

   • Justin P. Kumar

   Pages 75-97

5. Cell Morphogenesis: Tracing the Paths of Induction During Drosophila Ommatidial Development

   • Jennifer Curtiss

   Pages 99-140

6. Cell Polarity in Drosophila Retina

   • Sang-Chul Nam

   Pages 141-162

7. Negative Regulation for Neural Patterning in the Drosophila eye

   • Kwang-Wook Choi

   Pages 163-181

8. Cell Adhesion During Drosophila Eye Development

   • Ruth I. Johnson

   Pages 183-202

9. Modulation of Developmental Signaling by the Proteostasis Network

   • Kristin D. Patterson, Janice A. Fischer

   Pages 203-228

10. Drosophila Eye as a Model to Study Regulation of Growth Control: The Discovery of Size Control Pathways

    • Shilpi Verghese, Indrayani Waghmare, Shree Ram Singh, Madhuri Kango-Singh

    Pages 229-270

11. Unraveling the Basis of Neurodegeneration using the Drosophila Eye

    • Pedro Fernandez-Funez, Jonatan Sanchez-Garcia, Diego E. Rincon-Limas

    Pages 271-293

12. Genetic Regulation of Early Eye Development in Non-dipteran Insects

    • Markus Friedrich, Ying Dong, Zhenyi Liu, Iris Yang

    Pages 295-328

13. Development and Evolution of the Drosophila Bolwig’s Organ: A Compound Eye Relict

    • Markus Friedrich

    Pages 329-357

14. Back Matter

    Pages 359-368

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Undoubtedly, Drosophila melanogaster, fruit fly, has proved to be one of the most popular invertebrate model organisms, and the work horse for modern day biologists. Drosophila, a highly versatile model with a genetic legacy of more than a century, provides powerful genetic, cellular, biochemical and molecular biology tools to address many questions extending from basic biology to human diseases.  One of the most important questions in biology focuses on how does a multi-cellular organism develop from a single-celled embryo. The discovery of the genes responsible for pattern formation has helped refine this question, and led to other questions, such as the role of various genetics and cell biological pathways in regulating the crucial process of pattern formation and growth during organogenesis.  Drosophila eye model has been extensively used to study molecular genetic mechanisms involved in patterning and growth. Since the genetic machinery involved in the Drosophila eye is similar to humans, it has been used to model human diseases and homology to eyes in other taxa. This book will discuss molecular genetic mechanisms of pattern formation, mutations in axial patterning, Genetic regulation of growth in Drosophila eye, and more. There have been no titles in the past ten years covering this topic, thus an update is urgently needed.​

• developmental biology
• drosophila
• molecular genetics

• Department of Biology, University of Dayton, Dayton, USA

  Amit Singh

• Department of Biology Office: SC303C, University of Dayton, Dayton, USA

  Madhuri Kango-Singh

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