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G Protein-Coupled Receptor Kinases

  • Book
  • © 2016

Overview

Editors:
  1. Vsevolod V. Gurevich

    1. Department of Pharmacology, Vanderbilt University , NASHVILLE, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Eugenia V. Gurevich

    1. Department of Pharmacology, Vanderbilt University, Nashville, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John J.G. Tesmer

    1. Life Sciences Institute, University of Michigan, Ann Arbor, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Features detailed examinations of known GRK-dependent mechanisms, both associated with GPCR functions and receptor-independent
  • Covers a wide range of studies from invertebrates to humans
  • Provides practical advice from the experts on how to continue research on GRKs
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Pharmacology and Toxicology (MIPT)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xi
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  2. Introduction

    1. Front Matter

      Pages 1-1
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    2. G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and Discovery

      • Vsevolod V. Gurevich, Eugenia V. Gurevich
      Pages 3-22

  3. GRK Structure, Mechanisms of Activation, and Interactions with GPCRs

    1. Front Matter

      Pages 23-23
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    2. Structure and Function of G-Protein-Coupled Receptor Kinases 1 and 7

      • Tivadar Orban, Krzysztof Palczewski
      Pages 25-43

    3. Visual G Protein-Coupled Receptor Kinases

      • Chih-Chun Hsu, Ching-Kang Jason Chen
      Pages 45-57

    4. Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Receptor Kinase 4 Subfamily

      • Tyler S. Beyett, Sumit J. Bandekar, John J. G. Tesmer
      Pages 59-74

    5. “Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKs

      • Kunhong Xiao, Hongda Liu
      Pages 75-120

  4. GRKs in Cell Signaling

    1. Front Matter

      Pages 121-121
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    2. Cell-Type Specific GRK2 Interactomes: Pathophysiological Implications

      • Federico Mayor Jr., Rocío Vila-Bedmar, Laura Nogués, Marta Cruces-Sande, Elisa Lucas, Verónica Rivas et al.
      Pages 123-149

    3. Differential Regulation of IGF-1 and Insulin Signaling by GRKs

      • Leonard Girnita, Ada Girnita, Caitrin Crudden
      Pages 151-171

    4. Differential Control of Potassium Channel Activity by GRK2

      • Adi Raveh, Liora Guy-David, Eitan Reuveny
      Pages 173-183

  5. Physiological and Pathophysiological Mechanisms Regulated by GRKs

    1. Front Matter

      Pages 185-185
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    2. Critical Role of GRK2 in the Prevention of Chronic Pain

      • Faiza Baameur, Pooja Singhmar, Cobi J. Heijnen, Annemieke Kavelaars
      Pages 187-213

    3. Roles of GRK Dysfunction in Alzheimer’s Pathogenesis

      • William Z. Suo
      Pages 215-236

    4. Regulation of Dopamine-Dependent Behaviors by G Protein-Coupled Receptor Kinases

      • Eugenia V. Gurevich, Raul R. Gainetdinov, Vsevolod V. Gurevich
      Pages 237-269

    5. G-Protein-Coupled Receptors and Their Kinases in Cardiac Regulation

      • Alessandro Cannavo, Claudio de Lucia, Walter J. Koch
      Pages 271-281

    6. GRK Roles in C. elegans

      • Jordan F. Wood, Denise M. Ferkey
      Pages 283-299

    7. Evolutionarily Conserved Role of G-Protein-Coupled Receptor Kinases in the Hedgehog Signaling Pathway

      • Dominic Maier, David R. Hipfner
      Pages 301-324

  6. Back Matter

    Pages 325-329
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Keywords

About this book

This collection explores up-to-date descriptions of known G protein-coupled receptor kinase (GRK)-dependent mechanisms, both associated with G protein-coupled receptor (GPCR) functions and the receptor-independent. The chapters cover a wide range of studies from invertebrates to humans, with sections of the volume covering GRK structure, mechanisms of activation, and interaction with GPCRs, GRKs in cell signaling, as well as physiological and pathophysiological mechanisms regulated by GRKs.  Written for the Methods in Pharmacology and Toxicology series, this book features the kind of practical detail necessary for success in the laboratory. Authoritative and timely, G Protein-Coupled Receptor Kinases features the kind of comprehensive mechanistic elucidation of GRK functions and their regulation in cells necessary for a better understanding of cell biology as well as for devising novel research approaches and therapeutic strategies.

Editors and Affiliations

  • Department of Pharmacology, Vanderbilt University , NASHVILLE, USA

    Vsevolod V. Gurevich

  • Department of Pharmacology, Vanderbilt University, Nashville, USA

    Eugenia V. Gurevich

  • Life Sciences Institute, University of Michigan, Ann Arbor, USA

    John J.G. Tesmer

Bibliographic Information

  • Book Title: G Protein-Coupled Receptor Kinases

  • Editors: Vsevolod V. Gurevich, Eugenia V. Gurevich, John J.G. Tesmer

  • Series Title: Methods in Pharmacology and Toxicology

  • DOI: https://doi.org/10.1007/978-1-4939-3798-1

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3796-7Published: 21 July 2016

  • Softcover ISBN: 978-1-4939-8142-7Published: 31 May 2018

  • eBook ISBN: 978-1-4939-3798-1Published: 20 July 2016

  • Series ISSN: 1557-2153

  • Series E-ISSN: 1940-6053

  • Edition Number: 1

  • Number of Pages: XI, 329

  • Number of Illustrations: 3 b/w illustrations, 33 illustrations in colour

  • Topics: Pharmacology/Toxicology

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