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Mouse Models for Drug Discovery

Methods and Protocols

  • Book
  • © 2016

Overview

Editors:
  1. Gabriele Proetzel

    1. Takeda Pharmaceutical Company, Cambridge, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Michael V. Wiles

    1. The Jackson Laboratory, Bar Harbor, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Incudes fully updated cutting-edge methods and protocols for using mouse models in drug research
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts
  • Includes supplementary material: sn.pub/extras

Part of the book series: Methods in Molecular Biology (MIMB, volume 1438)

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Table of contents (21 protocols)

  1. Front Matter

    Pages i-xi
    Download chapter PDF

  2. Genetically Defined Strains in Drug Development and Toxicity Testing

    • Michael F. W. Festing
    Pages 1-17

  3. Simple, Efficient CRISPR-Cas9-Mediated Gene Editing in Mice: Strategies and Methods

    • Benjamin E. Low, Peter M. Kutny, Michael V. Wiles
    Pages 19-53

  4. Mouse Sperm Cryopreservation and Recovery of Genetically Modified Mice

    • Benjamin E. Low, Rob A. Taft, Michael V. Wiles
    Pages 55-66

  5. Generation of Immunodeficient Mice Bearing Human Immune Systems by the Engraftment of Hematopoietic Stem Cells

    • Suheyla Hasgur, Ken Edwin Aryee, Leonard D. Shultz, Dale L. Greiner, Michael A. Brehm
    Pages 67-78

  6. Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens

    • Markus von Schaewen, Gabriela Hrebikova, Alexander Ploss
    Pages 79-101

  7. Human FcRn Transgenic Mice for Pharmacokinetic Evaluation of Therapeutic Antibodies

    • Derry C. Roopenian, Gregory J. Christianson, Gabriele Proetzel, Thomas J. Sproule
    Pages 103-114

  8. A Humanized Mouse Model to Study Human Albumin and Albumin Conjugates Pharmacokinetics

    • Benjamin E. Low, Michael V. Wiles
    Pages 115-122

  9. Germ-Free Mice Model for Studying Host–Microbial Interactions

    • Yogesh Bhattarai, Purna C. Kashyap
    Pages 123-135

  10. Bridging Mice to Men: Using HLA Transgenic Mice to Enhance the Future Prediction and Prevention of Autoimmune Type 1 Diabetes in Humans

    • David V. Serreze, Marijke Niens, John Kulik, Teresa P. DiLorenzo
    Pages 137-151

  11. Mouse Models of Type 2 Diabetes Mellitus in Drug Discovery

    • Helene Baribault
    Pages 153-175

  12. Cholesterol Absorption and Metabolism

    • Philip N. Howles
    Pages 177-197

  13. Skin Diseases in Laboratory Mice: Approaches to Drug Target Identification and Efficacy Screening

    • John P. Sundberg, Kathleen A. Silva, Lloyd E. King Jr, C. Herbert Pratt
    Pages 199-224

  14. Chronic Myeloid Leukemia (CML) Mouse Model in Translational Research

    • Cong Peng, Shaoguang Li
    Pages 225-243

  15. Murine Model for Colitis-Associated Cancer of the Colon

    • Ashley J. Snider, Agnieszka B. Bialkowska, Amr M. Ghaleb, Vincent W. Yang, Lina M. Obeid, Yusuf A. Hannun
    Pages 245-254

  16. Mouse Models for Studying Depression-Like States and Antidepressant Drugs

    • Carisa L. Bergner, Amanda N. Smolinsky, Peter C. Hart, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 255-269

  17. Experimental Models of Anxiety for Drug Discovery and Brain Research

    • Peter C. Hart, Carisa L. Bergner, Amanda N. Smolinsky, Brett D. Dufour, Rupert J. Egan, Justin L. LaPorte et al.
    Pages 271-291

  18. Repetitive Behavioral Assessments for Compound Screening in Mouse Models of Autism Spectrum Disorders

    • Stacey J. Sukoff Rizzo
    Pages 293-310

  19. Better Utilization of Mouse Models of Neurodegenerative Diseases in Preclinical Studies: From the Bench to the Clinic

    • Christopher Janus, Carolina Hernandez, Victoria deLelys, Hanno Roder, Hans Welzl
    Pages 311-347

  20. Neuromuscular Disease Models and Analysis

    • Robert W. Burgess, Gregory A. Cox, Kevin L. Seburn
    Pages 349-394
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Keywords

About this book

With genetic engineering, systems explored in this book now exist allowing for the simple, efficient, and near universally precise genetic manipulation directly in any organism, including the mouse. Herein, these models are applied to a wide field of disease areas, including diabetes, cardiovascular disease, skin disorders, cancer, neurodegenerative and neuromuscular diseases, retinal disorders, as well as various behavioral models. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. 

Practical and fully updated, Mouse Models for Drug Discovery: Methods and Protocols, Second Edition serves to equip the reader with an extensive overview of techniques to utilize the many possibilities of mice in the drug development process.

Editors and Affiliations

  • Takeda Pharmaceutical Company, Cambridge, USA

    Gabriele Proetzel

  • The Jackson Laboratory, Bar Harbor, USA

    Michael V. Wiles

Bibliographic Information

  • Book Title: Mouse Models for Drug Discovery

  • Book Subtitle: Methods and Protocols

  • Editors: Gabriele Proetzel, Michael V. Wiles

  • Series Title: Methods in Molecular Biology

  • DOI: https://doi.org/10.1007/978-1-4939-3661-8

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3659-5Published: 06 May 2016

  • Softcover ISBN: 978-1-4939-8109-0Published: 26 May 2018

  • eBook ISBN: 978-1-4939-3661-8Published: 05 May 2016

  • Series ISSN: 1064-3745

  • Series E-ISSN: 1940-6029

  • Edition Number: 2

  • Number of Pages: XI, 436

  • Number of Illustrations: 26 b/w illustrations, 37 illustrations in colour

  • Topics: Pharmacology/Toxicology

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