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Ion Channels and Transporters of Epithelia in Health and Disease

  • Book
  • © 2016

Overview

Editors:
  1. Kirk L. Hamilton

    1. Department of Physiology, University of Otago , Dunedin, New Zealand

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    You can also search for this editor in PubMed   Google Scholar

  2. Daniel C Devor

    1. Department of Cell Biology, University of Pittsburgh, Pittsburgh, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Updates readers on essential findings concerning the cell physiology, biochemistry, pathophysiology and pharmacology of epithelial ion transport
  • Addresses both basic research and clinical aspects
  • All chapters written by leading scientists and clinicians
  • Includes supplementary material: sn.pub/extras

Part of the book series: Physiology in Health and Disease (PIHD)

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Table of contents (29 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Basic Epithelial Ion Transport Principles and Function

    1. Front Matter

      Pages 1-1
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    2. Fundamentals of Epithelial Cl− Transport

      • Bruce D. Schultz, Daniel C. Devor
      Pages 3-47

    3. Fundamentals of Epithelial Na+ Absorption

      • Alexander Staruschenko, Daria V. Ilatovskaya, Kenneth R. Hallows
      Pages 49-94

    4. Physiologic Influences of Transepithelial K+ Secretion

      • Dan R. Halm
      Pages 95-130

    5. Volume Regulation in Epithelia

      • Erik Hviid Larsen, Else Kay Hoffmann
      Pages 131-185

    6. Fundamentals of Bicarbonate Secretion in Epithelia

      • Ivana Novak, Jeppe Praetorius
      Pages 187-263

    7. Mathematical Modeling of Epithelial Ion Transport

      • David P. Nickerson, Kirk L. Hamilton, Peter J. Hunter
      Pages 265-278

    8. Molecular Mechanisms of Apical and Basolateral Sorting in Polarized Epithelial Cells

      • Ora A. Weisz, Heike Fölsch
      Pages 279-302

    9. Membrane Protein Folding and Structure

      • Liang Zhang, Patrick H. Thibodeau
      Pages 303-331

  3. Epithelial Ion Channels and Transporters

    1. Front Matter

      Pages 333-333
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    2. P2X Receptors in Epithelia

      • Jens Leipziger
      Pages 335-350

    3. Na+/K+-ATPase Drives Most Asymmetric Transports and Modulates the Phenotype of Epithelial Cells

      • Marcelino Cereijido, Isabel Larre, Omar Paez, Liora Shoshani, Arturo Ponce
      Pages 351-374

    4. Na+-K+-2Cl− Cotransporter

      • Eric Delpire, Kenneth B. Gagnon
      Pages 375-400

    5. Thiazide-Sensitive NaCl Cotransporter

      • Arohan R. Subramanya
      Pages 401-435

    6. NBCe1, an Electrogenic Na+ Bicarbonate Cotransporter, in Epithelia

      • Aleksandra SinÄ‘ić, Michael F. Romero
      Pages 437-463

    7. Properties and Function of the Solute Carrier 26 Family of Anion Transporters

      • Nikolay Shcheynikov, Ehud Ohana, Shmuel Muallem
      Pages 465-489

    8. ClC-2 Chloride Channels

      • John Cuppoletti, Danuta H. Malinowska, Ryuji Ueno
      Pages 491-518

    9. CFTR and Cystic Fibrosis

      • William T. Harris, Kevin L. Kirk
      Pages 519-552

    10. TMEM16 Proteins (Anoctamins) in Epithelia

      • Paolo Scudieri, Luis J. V. Galietta
      Pages 553-567
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Keywords

About this book

This book sheds new light on the physiology, molecular biology and pathophysiology of epithelial ion channels and transporters. It combines the basic cellular models and functions by means of a compelling clinical perspective, addressing aspects from the laboratory bench to the bedside. The individual chapters, written by leading scientists and clinicians, explore specific ion channels and transporters located in the epithelial tissues of the kidney, intestine, pancreas and respiratory tract, all of which play a crucial part in maintaining homeostasis. Further topics include the fundamentals of epithelial transport; mathematical modeling of ion transport; cell volume regulation; membrane protein folding and trafficking; transepithelial transport functions; and lastly, a discussion of transport proteins as potential pharmacological targets with a focus on the pharmacology of potassium channels. 

Editors and Affiliations

  • Department of Physiology, University of Otago , Dunedin, New Zealand

    Kirk L. Hamilton

  • Department of Cell Biology, University of Pittsburgh, Pittsburgh, USA

    Daniel C Devor

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