Skip to main content
SpringerLink
Log in

Regenerative Medicine for Degenerative Muscle Diseases

  • Book
  • © 2016

Overview

Editors:
  1. Martin K. Childers

    1. Department of Rehabilitation Medicine, University of Washington Department of Rehabilitation Medicine, WINSTON SALEM, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Examines new and developing regenerative medicine enabling technologies for the treatment of patients with degenerative diseases of skeletal muscle
  • Provides a rapid look at new approaches to old conditions that impact thousands of patients and their families worldwide
  • Presents a new regenerative medicine approach to treatment or discovery

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (12 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Regenerative Medicine Approaches to Degenerative Muscle Diseases

    • Martin K. Childers, Zejing Wang
    Pages 1-20

  3. An Overview of rAAV Vector Product Development for Gene Therapy

    • Richard O. Snyder
    Pages 21-37

  4. Gene Discovery in Congenital Myopathy

    • Laura L. Smith, Vandana A. Gupta, Alan H. Beggs
    Pages 39-83

  5. Stem Cell Transplantation for Degenerative Muscle Diseases

    • Berkcan Akpinar, Elizabeth C. Stahl, Aiping Lu, Johnny Huard
    Pages 85-108

  6. Spinal Cord Cellular Therapeutics Delivery: Device Design Considerations

    • Khalid Medani, Jonathan Riley, Jason Lamanna, Nicholas Boulis
    Pages 109-127

  7. Patient-Derived Induced Pluripotent Stem Cells Provide a Regenerative Medicine Platform for Duchenne Muscular Dystrophy Heart Failure

    • Xuan Guan, David Mack, Martin K. Childers
    Pages 129-155

  8. Overview of Chemistry, Manufacturing, and Controls (CMC) for Pluripotent Stem Cell-Based Therapies

    • Amy Lynnette Van Deusen, Michael Earl McGary
    Pages 157-203

  9. Regenerative Rehabilitation: Synergizing Regenerative Medicine Therapies with Rehabilitation for Improved Muscle Regeneration in Muscle Pathologies

    • Kristen Stearns-Reider, Fabrisia Ambrosio
    Pages 205-224

  10. Practical Nutrition Guidelines for Individuals with Duchenne Muscular Dystrophy

    • Zoe E. Davidson, Greg Rodden, Davi A. G. Mázala, Cynthia Moore, Carol Papillon, Angela J. Hasemann et al.
    Pages 225-279

  11. Identifying Therapies for Muscle Disease Using Zebrafish

    • Elizabeth U. Parker, Lisa Maves
    Pages 281-293

  12. miRNAs in Muscle Diseases

    • Diem-Hang Nguyen-Tran, Hannele Ruohola-Baker
    Pages 295-307

  13. Canine-Inherited Dystrophinopathies and Centronuclear Myopathies

    • Joe N. Kornegay, Martin K. Childers
    Pages 309-329

  14. Back Matter

    Pages 331-336
    Download chapter PDF
Back to top

Keywords

About this book

This book compiles and explores cutting-edge research in degenerative skeletal disorders, such as Duchenne muscular dystrophy and congenital myopathy, and new stem-cell based therapies and gene replacement therapy. Twelve expertly-authored chapters navigate the nuances of these treatments in an array of contexts and biological systems. The topics covered include: How are urine cells from a patient with Duchenne muscular dystrophy transformed into beating heart cells? What can reprogrammed cells tell us about heart muscle failure? What do gene mutations mean for those born with a muscle disease? How are manufacturing methods applied to human stem cells? Does therapeutic exercise benefit those patients who receive engineered limb muscle? Is there practical advice about nutrition to enhance muscle function for the Duchenne patient? Can microRNAs be useful to regenerate diseased muscle?

 Regenerative Medicine for Degenerative Muscle Diseases is ideal for scientists and clinicians from varying disciplines in genetics, cell biology, virology, cell-based manufacturing, rehabilitation medicine, nutrition, veterinary medicine and neurosurgery. The reader will see how transformative changes occur in medicine that can powerfully impact the future for patients suffering from inherited disorders affecting muscles of the body, including the heart.

Editors and Affiliations

  • Department of Rehabilitation Medicine, University of Washington Department of Rehabilitation Medicine, WINSTON SALEM, USA

    Martin K. Childers

About the editor

Martin K. (Casey) Childers, D.O., Ph.D.  is a professor in the Department of Rehabilitation Medicine and Investigator at the Institute for Stem Cell & Regenerative Medicine, University of Washington. He is a graduate of Seattle Pacific University  (B.A., Music Performance), Western University (D.O., Medicine, Osteopathic) and The University of Missouri (Ph.D., Physiology & Pharmacology; residency, Rehabilitation Medicine). The Childers' laboratory works in two areas of investigation. In a series of preclinical studies, they address the hurdles required for systemic gene replacement delivery for patients with X-Linked Myotubular Myopathy (XLMTM). In other studies, they use a "disease in a dish" approach with induced pluripotent stem (iPS) cells to study heart disease in patients with Duchenne muscular dystrophy (DMD). Dr. Childers clinical medicine practice at the University of Washington Medical Center is dedicated to serve patients with neuromuscular diseases.

Bibliographic Information

  • Book Title: Regenerative Medicine for Degenerative Muscle Diseases

  • Editors: Martin K. Childers

  • Series Title: Stem Cell Biology and Regenerative Medicine

  • DOI: https://doi.org/10.1007/978-1-4939-3228-3

  • Publisher: Humana New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer Science+Business Media New York 2016

  • Hardcover ISBN: 978-1-4939-3227-6Published: 19 December 2015

  • Softcover ISBN: 978-1-4939-8001-7Published: 29 March 2019

  • eBook ISBN: 978-1-4939-3228-3Published: 19 December 2015

  • Series ISSN: 2196-8985

  • Series E-ISSN: 2196-8993

  • Edition Number: 1

  • Number of Pages: XIII, 336

  • Number of Illustrations: 3 b/w illustrations, 23 illustrations in colour

  • Topics: Stem Cells, Biotechnology

Publish with us

Policies and ethics

Back to top

Search

Navigation