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Microfluidic and Compartmentalized Platforms for Neurobiological Research

  • Book
  • © 2015

Overview

Editors:
  1. Emilia Biffi

    1. Bioengineering Laboratory, Department of Electronics, Information and Bioengineering, Scientific Institute IRCCS E. Medea, Bosisio Parini (LC), Milano, Italy

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    You can also search for this editor in PubMed   Google Scholar

  • Includes cutting-edge methods and protocols
  • Provides step-by-step detail essential for reproducible results
  • Contains key notes and implementation advice from the experts

Part of the book series: Neuromethods (NM, volume 103)

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Table of contents (14 protocols)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Designs and Methods

    1. Front Matter

      Pages 1-1
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    2. The Fabrication of Microfluidic Platforms with Pneumatically/Hydraulically Controlled PDMS Valves and Their Use in Neurobiological Research

      • Bryson M. Brewer, Donna J. Webb, Deyu Li
      Pages 3-23

    3. A Reliable Reversible Bonding Method for Perfused Microfluidic Devices

      • Paola Occhetta, Emilia Biffi, Marco Rasponi
      Pages 25-38

    4. Bridging Two Cultures: Minimalistic Networks Prepared by Microfluidic Arraying, and Open Access Compartments for Electrophysiology

      • Jonathan West, Ngoc-Duy Dinh, Heike Hardelauf, Ya-Yu Chiang, Tracey A. Newman, Mariana Vargas-Caballero et al.
      Pages 39-56

  3. Axonal Guidance and Manipulation

    1. Front Matter

      Pages 57-57
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    2. Asymmetric Genetic Manipulation and Patch Clamp Recording of Neurons in a Microfluidic Chip

      • Prasanna Sakha, Cecilia Brunello, Joonas Heikkinen, Ville Jokinen, Henri J. Huttunen
      Pages 59-81

    3. Development of a Compartmentalized Biochip for Axonal Isolation and Neuronal-Circuit Formation at the Single-Cell Level

      • Ting Huang, Russell K. Pirlo, Wan Qin, Yongliang Lin, Lina Wei, Lucas Schmidt et al.
      Pages 83-104

    4. Campenot Cultures and Microfluidics Provide Complementary Platforms for Spatial Study of Dorsal Root Ganglia Neurons

      • Sara J. Fenstermacher, Maria F. Pazyra-Murphy, Rosalind A. Segal
      Pages 105-124

  4. Manipulation of Synapses

    1. Front Matter

      Pages 125-125
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    2. Development of Microfluidic Devices for the Manipulation of Neuronal Synapses

      • Anika Jain, Martha U. Gillette
      Pages 127-137

    3. Use of a 3-Compartment Microfluidic Device to Study Activity Dependent Synaptic Competition

      • Ainsley Coquinco, Max Cynader
      Pages 139-146

  5. Interaction of Different Cell Populations

    1. Front Matter

      Pages 147-147
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    2. Multi-compartment Neuron–Glia Coculture Microsystem

      • Jaewon Park, Sunja Kim, Jianrong Li, Arum Han
      Pages 149-159

    3. Compartmentalized Microfluidic Platforms as Tool of Choice to Study the Interaction Between Neurons and Osteoblasts

      • Estrela Neto, Diogo Paramos-de-Carvalho, Ana Henriques Lourenço, Paulo Aguiar, Meriem Lamghari
      Pages 161-179

    4. A Novel In Vitro Primary Culture Model of the Lower Motor Neuron–Neuromuscular Junction Circuit

      • Katherine A. Southam, Anna E. King, Catherine A. Blizzard, Graeme H. McCormack, Tracey C. Dickson
      Pages 181-193

  6. Pharmacological Manipulation and Screening

    1. Front Matter

      Pages 195-195
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    2. Compartmentalized Microfluidics for In Vitro Alzheimer’s Disease Studies

      • Yufei Ren, Anja Kunze, Philippe Renaud
      Pages 197-215

    3. Selective Biochemical Manipulation of Twin Neuronal Networks on Microelectrode Arrays

      • Giulia Regalia, Emilia Biffi, Marco Rasponi, Alessandra Pedrocchi
      Pages 217-230

    4. Compartmentalized Synapse Microarray for High-Throughput Screening

      • Amol D. Jadhav, Wei Li, Zhen Xu, Peng Shi
      Pages 231-245
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Keywords

About this book

This volume presents cutting-edge techniques to design, fabricate and use compartmentalized microfluidic devices. Chapters encompass axon guidance and manipulation, compartmentalized devices for synapse manipulation, cell populations interaction either in physiological or pathological condition and compartmentalized devices for pharmacological research and drug discovery. Written in the popular Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your own laboratory.

Authoritative and practical, Microfluidic and Compartmentalized Platforms for Neurobiological Research provides practical skills needed to fabricate, use microfluidics and compartmentalized platforms with neuronal cell cultures as well as the strengths of these exciting devices and their precious contribution in the field of Neuroscience.

Editors and Affiliations

  • Bioengineering Laboratory, Department of Electronics, Information and Bioengineering, Scientific Institute IRCCS E. Medea, Bosisio Parini (LC), Milano, Italy

    Emilia Biffi

Bibliographic Information

  • Book Title: Microfluidic and Compartmentalized Platforms for Neurobiological Research

  • Editors: Emilia Biffi

  • Series Title: Neuromethods

  • DOI: https://doi.org/10.1007/978-1-4939-2510-0

  • Publisher: Humana New York, NY

  • eBook Packages: Springer Protocols

  • Copyright Information: Springer Science+Business Media New York 2015

  • Hardcover ISBN: 978-1-4939-2509-4Published: 11 March 2015

  • Softcover ISBN: 978-1-4939-5561-9Published: 05 October 2016

  • eBook ISBN: 978-1-4939-2510-0Published: 10 March 2015

  • Series ISSN: 0893-2336

  • Series E-ISSN: 1940-6045

  • Edition Number: 1

  • Number of Pages: XIII, 248

  • Number of Illustrations: 9 b/w illustrations, 63 illustrations in colour

  • Topics: Neurosciences, Neurobiology

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