Mitochondrial Function in Lung Health and Disease

1. Front Matter

   Pages i-xi

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2. Role of Mitochondrial Reactive Oxygen and Nitrogen Species in Respiratory Diseases

   • Harijith Anantha, Prasad Kanteti, Panfeng Fu, Sainath R. Kotha, Narasimham L. Parinandi, Viswanathan Natarajan

   Pages 1-25

3. Regulation of Mitochondrial Functions by Transcription Factor NRF2

   • Narsa M. Reddy, Wajiha Qureshi, Haranath Potteti, Dhananjaya V. Kalvakolanu, Sekhar P. Reddy

   Pages 27-50

4. Mitochondrion: A Missing Link in Asthma Pathogenesis

   • Ulaganathan Mabalirajan, Anurag Agrawal, Balaram Ghosh

   Pages 51-70

5. ROS Signaling in Cardiovascular Dysfunction Associated with Obstructive Sleep Apnea

   • Ganesh K. Kumar, Gayatri Raghuraman, Nanduri R. Prabhakar

   Pages 71-91

6. Mitochondrial Excitation-Energy Coupling in Airway Smooth Muscle

   • Niccole Schaible, Philippe Delmotte, Gary C. Sieck

   Pages 93-116

7. Mitochondrial Lipid Peroxidation in Lung Damage and Disease

   • Sainath R. Kotha, Travis O. Gurney, Miles U. Magalang, Thomas J. Hund, Abhay R. Satoskar, Peter J. Mohler et al.

   Pages 117-139

8. The Impact of DNA Damage on Epithelial Cell Maintenance of the Lung

   • Lidza Kalifa, Michael A. O’Reilly

   Pages 141-159

9. Mitochondrial Function in Lung Health and Disease

   • Luis Puente-Maestu, Jorge Chancafe-Morgan

   Pages 161-176

10. Age-Specific Difference in Pulmonary Cellular Injury and Mitochondrial Damage

    • Katherine L. Tuggle, Michelle V. Fanucchi

    Pages 177-214

11. Back Matter

    Pages 215-222

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Mitochondria, often referred to as the “powerhouses” of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.

• Biogenesis
• Fibrosis
• Lung health
• Mitochondria
• Pulmonary Arterial Hypertension
• Sepsis

• Department of Pharmaology and Medicine, University of Illinois at Chicago, Chicago, USA

  Viswanathan Natarajan

• Division of Allergy, Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, College of Medicine, Ohio State University Wexner, Medical Center, Columbus, USA

  Narasimham L. Parinandi

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