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Adipose Tissue and Cancer

  • Book
  • © 2013

Overview

Editors:
  1. Mikhail G. Kolonin

    1. Science Center at Houston, Inst. Molecular Medicine, University of Texas, Houston, USA

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  • Explores relationship between obesity and cancer
  • Examines direct effect of adipose tissue on cancer
  • Discusses role of endocrine signaling by adipose tissue-derived molecules in cancer promotion

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-viii
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  2. Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity–Cancer Link

    • Nikki A. Ford, John DiGiovanni, Stephen D. Hursting
    Pages 1-14

  3. Increased Adiposity and Colorectal Cancer

    • Charles Bellows, Herbert Tilg
    Pages 15-32

  4. Adiposity and Diabetes in Breast and Prostate Cancer

    • Linda Vona-Davis, David P. Rose
    Pages 33-51

  5. Increased Adiposity and Endometrial Cancer Risk

    • Karen H. Lu, Ann H. Klopp, Pamela T. Soliman, Rosemarie E. Schmandt
    Pages 53-69

  6. Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer

    • Gilberto Paz-Filho, Ameet Kumar Mishra, Julio Licinio
    Pages 71-97

  7. Animal Models to Study the Interplay Between Cancer and Obesity

    • Amitabha Ray, Margot P. Cleary
    Pages 99-119

  8. Unraveling the Local Influence of Tumor-Surrounding Adipose Tissue on Tumor Progression: Cellular and Molecular Actors Involved

    • Catherine Muller, Laurence Nieto, Philippe Valet
    Pages 121-146

  9. Trafficking of Cells from Adipose Tissue to Tumor Microenvironment

    • Ines Martin-Padura, Patrizia Mancuso, Francesco Bertolini
    Pages 147-163

  10. The Impact of Obesity Intervention on Cancer: Clinical Perspectives

    • Ted D. Adams, Jessica L. J. Greenwood, Steven C. Hunt
    Pages 165-187

  11. Back Matter

    Pages 189-190
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Keywords

About this book

Recent studies have shown that cells from adipose tissue are capable of trafficking to tumors, thus enabling paracrine action of adipokines from within the tumor microenvironment. Increased tumor vascularization, immune system suppression and direct effects on malignant cell survival and proliferation have been investigated as mechanisms regulated by adipokines. The goal of this book is to discuss data pointing to the role of adipose tissue in cancer and to dissect individual mechanisms through which adipose tissue excess or restriction could influence cancer progression.

Editors and Affiliations

  • Science Center at Houston, Inst. Molecular Medicine, University of Texas, Houston, USA

    Mikhail G. Kolonin

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