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Prominin-1 (CD133): New Insights on Stem & Cancer Stem Cell Biology

  • Book
  • © 2013

Overview

Editors:
  1. Denis Corbeil

    1. , Biotechnological Centre (BIOTEC), Dresden University of Technology, Dresden, Germany

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  • Provides exciting new research on prominin-1/CD133 and its role in expression in cancer stem cells
  • Explores the role of the prominin family and presents new information regarding the regulation of prominin-1 ?
  • Evaluates prominin-1/CD133 as a stem cell marker for cancers and other diseases and presents future prospects for its potential role in regenerative therapy
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 777)

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Table of contents (15 chapters)

  1. Front Matter

    Pages i-xv
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  2. Biology of Prominins

    1. Front Matter

      Pages 1-1
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    2. Prominin-1 (CD133): Molecular and Cellular Features Across Species

      • Denis Corbeil, Jana Karbanová, Christine A. Fargeas, József Jászai
      Pages 3-24

    3. Prominin-2 and Other Relatives of CD133

      • Christine A. Fargeas
      Pages 25-40

    4. Prominin-1-Containing Membrane Vesicles: Origins, Formation, and Utility

      • Anne-Marie Marzesco
      Pages 41-54

    5. Prominent Role of Prominin in the Retina

      • Nagananda Gurudev, Mareike Florek, Denis Corbeil, Elisabeth Knust
      Pages 55-71

    6. Gene Regulation of Prominin-1 (CD133) in Normal and Cancerous Tissues

      • Kouichi Tabu, Norihisa Bizen, Tetsuya Taga, Shinya Tanaka
      Pages 73-85

  3. Prominin-1/CD133 and Stem Cells

    1. Front Matter

      Pages 87-87
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  4. Prominin-1/CD133 And Stem Cells

    1. Prominin-1 (CD133) and the Cell Biology of Neural Progenitors and Their Progeny

      • Alex M. Sykes, Wieland B. Huttner
      Pages 89-98

    2. CD133-Positive Hematopoietic Stem Cells: From Biology to Medicine

      • Rupert Handgretinger, Selim Kuçi
      Pages 99-111

    3. New Insights into the Renal Progenitor Cells and Kidney Diseases by Studying CD133

      • Benedetta Bussolati, Giovanni Camussi
      Pages 113-123

    4. CD133 Expression Strongly Correlates with the Phenotype of Very Small Embryonic-/Epiblast-Like Stem Cells

      • Mariusz Z. Ratajczak, Kasia Mierzejewska, Janina Ratajczak, Magda Kucia
      Pages 125-141

  5. Prominin-1/CD133 and the Cancer Stem Cell Hypothesis

    1. Front Matter

      Pages 143-143
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  6. Prominin-1/CD133 And The Cancer Stem Cell Hypothesis

    1. New Insights into the CD133 (Prominin-1) Expression in Mouse and Human Colon Cancer Cells

      • Alessandro Sgambato, Maddalena Corbi, Maria Svelto, Emanuele Caredda, Achille Cittadini
      Pages 145-166

    2. Prominin-1 (CD133) Expression in the Prostate and Prostate Cancer: A Marker for Quiescent Stem Cells

      • Davide Pellacani, Emma E. Oldridge, Anne T. Collins, Norman J. Maitland
      Pages 167-184

    3. Prominin-1 (CD133) Reveals New Faces of Pancreatic Progenitor Cells and Cancer Stem Cells: Current Knowledge and Therapeutic Perspectives

      • Yuichi Hori
      Pages 185-196

    4. Prominin-1 (CD133) and Metastatic Melanoma: Current Knowledge and Therapeutic Perspectives

      • Aurelio Lorico, Javier Mercapide, Germana Rappa
      Pages 197-211

  7. Future Perspectives: From Basic Research to Medical Application

    1. Front Matter

      Pages 213-213
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  8. Future perspectives – from Basic Research to Medical Application

    1. CD133-Positive Cells for Cardiac Stem Cell Therapy: Current Status and Outlook

      • Peter Donndorf, Gustav Steinhoff
      Pages 215-227

    2. CD133+ Cells for the Treatment of Degenerative Diseases: Update and Perspectives

      • Mirella Meregalli, Andrea Farini, Marzia Belicchi, Yvan Torrente
      Pages 229-243
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Keywords

About this book

​​​​​​​Prominin-1 or otherwise known as CD133 is a glycoprotein that is present in humans and mice. Since the first description of prominin in 1997, in mouse neuroepithelial cells and in human hematopoietic stem cells as AC133 antigen, this molecule has aroused a large interest especially, as a stem cell marker, that gave rise to an ever growing body of publications and more recently its expression in cancer stem cells. Controversies as to its role as a cancer stem and its detection in different models, as well as its use as a prognostic marker have emerged. Yet, beyond its use as a stem cell and cancer stem cell marker, prominin-1/CD133 displays unique biological features and appears of importance in other processes like for example in retinal biogenesis. Indeed, this five-transmembrane plasma membrane glycoprotein, which marks membrane protrusions is associated with several essential processes like cell polarity, asymmetric cell division and membrane remodeling. We propose to review current knowledge about this intriguing molecule and present pertinent information to determine the biological role of prominins and assess their importance in medicine and cancer research. The primary audience for this book is geared towards scientists and researchers with interest in cancer stem cells, stem cells, cell biology, neurobiology, and regenerative medicine.

Editors and Affiliations

  • , Biotechnological Centre (BIOTEC), Dresden University of Technology, Dresden, Germany

    Denis Corbeil

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