Skip to main content
SpringerLink
Log in
Book cover

Hypoxia

Translation in Progress

  • Book
  • © 2016

Overview

Editors:
  1. Robert C. Roach

    1. Altitude Research Center, University of Colorado Anschutz Medical, AURORA, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Peter H. Hackett

    1. Institute for Altitude Medicine, Telluride, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Peter D. Wagner

    1. Division of Physiology 0623A, University of California - San Diego, La Jolla, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Discusses the latest up-to-date research and discoveries related to hypoxia
  • Spans reviews on key topics in hypoxia
  • Covers findings revealed at the latest International Hypoxia Symposia
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 903)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (30 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Epigenetic Alterations in Hypoxia

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Epigenetic Mechanisms as an Interface Between the Environment and Genome

      • Zdenko Herceg
      Pages 3-15

    3. Developmental Origins of Hypoxic Pulmonary Hypertension and Systemic Vascular Dysfunction: Evidence from Humans

      • Claudio Sartori, Stefano F. Rimoldi, Hervé Duplain, Thomas Stuber, Sophie Garcin, Emrush Rexhaj et al.
      Pages 17-28

    4. Acquired Mitochondrial Abnormalities, Including Epigenetic Inhibition of Superoxide Dismutase 2, in Pulmonary Hypertension and Cancer: Therapeutic Implications

      • Stephen L. Archer
      Pages 29-53

    5. Epigenetics in Cardiovascular Regulation

      • Claudio Sartori, Stefano F. Rimoldi, Emrush Rexhaj, Yves Allemann, Urs Scherrer
      Pages 55-62

  3. Hypoxia and High Altitude Residents

    1. Front Matter

      Pages 63-63
      Download chapter PDF

    2. Why Are High-Altitude Natives So Strong at Altitude? Maximal Oxygen Transport to the Muscle Cell in Altitude Natives

      • Carsten Lundby, Jose A. L. Calbet
      Pages 65-81

    3. Novel Insights into Cardiovascular Regulation in Patients with Chronic Mountain Sickness

      • Stefano F. Rimoldi, Emrush Rexhaj, Mercedes Villena, Carlos Salinas Salmon, Yves Allemann, Urs Scherrer et al.
      Pages 83-100

    4. Why Are High Altitude Natives So Strong at High Altitude? Nature vs. Nurture: Genetic Factors vs. Growth and Development

      • Tom Brutsaert
      Pages 101-112

    5. Functional Genomic Insights into Regulatory Mechanisms of High-Altitude Adaptation

      • Jay F. Storz, Zachary A. Cheviron
      Pages 113-128

  4. Hypoxia and the Brain

    1. Front Matter

      Pages 129-129
      Download chapter PDF

    2. Influence of Hypoxia on Cerebral Blood Flow Regulation in Humans

      • Craig D. Steinback, Marc J. Poulin
      Pages 131-144

    3. Imaging the Respiratory Effects of Opioids in the Human Brain

      • Kyle T. S. Pattinson, Richard G. Wise
      Pages 145-156

    4. Regional Cerebrovascular Responses to Hypercapnia and Hypoxia

      • Douglas R. Corfield, Leanne C. McKay
      Pages 157-167

    5. Implications of Oxygen Homeostasis for Tumor Biology and Treatment

      • Boyan K. Garvalov, Till Acker
      Pages 169-185

    6. Hyperoxia and Functional MRI

      • Daniel Bulte
      Pages 187-199

    7. Astrocytes and Brain Hypoxia

      • Nephtali Marina, Vitaliy Kasymov, Gareth L. Ackland, Sergey Kasparov, Alexander V. Gourine
      Pages 201-207

    8. Bidirectional Control of Blood Flow by Astrocytes: A Role for Tissue Oxygen and Other Metabolic Factors

      • Grant R. J. Gordon, Clare Howarth, Brian A. MacVicar
      Pages 209-219

    9. Hypoxic Adaptation in the Nervous System: Promise for Novel Therapeutics for Acute and Chronic Neurodegeneration

      • Rachel Speer, Rajiv R. Ratan
      Pages 221-243
Back to top

Keywords

About this book

The latest in a series of books from the International Hypoxia Symposia, this volume spans reviews on key topics in hypoxia, and abstracts from poster and oral presentations. The biannual International Hypoxia Symposia are dedicated to hosting the best basic scientific and clinical minds to focus on the integrative and translational biology of hypoxia. Long before ‘translational medicine’ was a catchphrase, the founders of the International Hypoxia Symposia brought together basic scientists, clinicians and physiologists to live, eat, ski, innovate and collaborate in the Canadian Rockies.

This collection of reviews and abstracts is divided into six sections, each covering new and important work relevant to a broad range of researchers interested in how humans adjust to hypoxia, whether on the top of Mt. Everest or in the pulmonary or cardiology clinic at low altitude. The sections include:

  • Epigenetic Variations in Hypoxia
    High Altitude Adaptation
  • Hypoxia and Sleep
  • Hypoxia and the Brain
  • Molecular Oxygen Sensing
  • Physiological Responses to Hypoxia

Editors and Affiliations

  • Altitude Research Center, University of Colorado Anschutz Medical, AURORA, USA

    Robert C. Roach

  • Institute for Altitude Medicine, Telluride, USA

    Peter H. Hackett

  • Division of Physiology 0623A, University of California - San Diego, La Jolla, USA

    Peter D. Wagner

About the editors

Dr. Robert Roach is the Director of the Altitude Research Center at the University of Colorado. He specializes in the study of physiological adaptations by humans to high altitude, with a recent emphasis on the genomic responses to allow humans to thrive in hypoxia. 

Dr. Peter Wagner is a Distinguished Professor of Medicine and Bioengineering at the University of California, San Diego. His research addresses the theoretical and experimental basis of oxygen transport and its limitations in the lungs and skeletal muscles in health and disease. 


Dr. Peter Hackett is a world-renowned high altitude expert and altitude research pioneer. He is a leading authority on altitude illness, high altitude climbing, wilderness medicine, and the effects of altitude on people living and working in the mountains.

Bibliographic Information

  • Book Title: Hypoxia

  • Book Subtitle: Translation in Progress

  • Editors: Robert C. Roach, Peter H. Hackett, Peter D. Wagner

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4899-7678-9

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2016

  • Hardcover ISBN: 978-1-4899-7676-5Published: 25 June 2016

  • Softcover ISBN: 978-1-4939-7948-6Published: 30 May 2018

  • eBook ISBN: 978-1-4899-7678-9Published: 24 June 2016

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 772

  • Number of Illustrations: 89 b/w illustrations, 14 illustrations in colour

  • Topics: Human Physiology, Immunology, Neurosciences, Pneumology/Respiratory System

Publish with us

Policies and ethics

Back to top

Search

Navigation