Animal Models in Psychiatry, I

1. Front Matter

   Pages i-xix

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2. Methods for Assessing the Validity of Animal Models of Human Psychopathology

   • Paul Willner

   Pages 1-23

3. Animal Models with Parallels to Schizophrenia

   • Melvin Lyon

   Pages 25-65

4. The Hippocampal-Lesion Model of Schizophrenia

   • Nestor A. Schmauk, Mabel Tyberg

   Pages 67-102

5. An Animal Model of Stimulant Psychoses

   • Mathew T. Martin-Iverson

   Pages 103-150

6. Animal Models of Hallucinations

   • Gaylord D. Ellison

   Pages 151-196

7. Animal Models for the Symptoms of Mania

   • Melvin Lyon

   Pages 197-244

8. Animal Models in Tardive Dyskinesia

   • Helen Rosengarten, Jack W. Schweitzer, Arnold J. Friedhoff

   Pages 245-266

9. Activity Anorexia

   • W. David Pierce, W. Frank Epling

   Pages 267-311

10. An Animal Model of Attention Deficit

    • Joram Feldon, Ina Weiner

    Pages 313-361

11. A Computerized Methodology for the Study of Neuroleptic-Induced Oral Dyskinesias

    • Gaylord Ellison, Ronald E. See

    Pages 363-397

12. Back Matter

    Pages 395-411

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The two Animal Models in Psychiatry volumes are loosely organized by subject. The first volume contains a number of chapters concerned with schizophrenia, psyc- ses, neuroleptic-induced tardive dyskinesias, and other d- orders that may involve dopamine, such as attention deficit disorder and mania. The second volume deals with affective and anxiety disorders, but also includes chapters on subjects not easily classified as either psychotic, or affective, or an- ety-related, such as aggression, mental retardation, and memory disorders. Four chapters on animal models of schizophrenia or psychoses are included in the present v- ume because of the importance of these disorders in p- chiatry. Likewise, three chapters in the subsequent volume deal with depression. The first of the two volumes begins with an introd- tion by Paul Willner reviewing the criteria for assessing the validity of animal models in psychiatry. He has written - tensively on this subject, and his thorough description of the issues of various forms of validity provides a framework in which to evaluate the subsequent chapters. As will be seen, the remaining chapters in both volumes will refer frequently to these issues. The second chapter, by Melvin Lyon, describes a large number of different procedures that have been p- posed as potential animal models of schizophrenia. This is a departure from the usual format, consisting of detailed - scriptions of specific models.

...extremely valuable for readers in the fields of psychopharmacology and biological psychiatry. -Quarterly Review of Biology

• University of Saskatchewan, Saskatoon, Canada

  Alan A. Boulton

• University of Alberta, Edmonton, Canada

  Glen B. Baker, Mathew T. Martin-Iverson

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