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Molecular Biology of Aging

  • Book
  • © 1985

Overview

Editors:
  1. Avril D. Woodhead

    1. Brookhaven National Laboratory, Upton, USA

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  2. Anthony D. Blackett

    1. University of Manchester Institute of Science and Technology, Manchester, UK

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  3. Alexander Hollaender

    1. Council for Research Planning in Biological Sciences, Inc., USA

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Part of the book series: Basic Life Sciences (BLSC, volume 35)

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Table of contents (30 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Symposium Lecture - I

    1. Aging Research: Challenge of the Twenty-First Century

      • E. L. Schneider
      Pages 1-11

  3. Wear and Tear Hypotheses

    1. Introductory Remarks, Session II

      • J. R. Totter
      Pages 13-14

    2. Antioxidants and Longevity of Mammalian Species

      • Richard G. Cutler
      Pages 15-73

    3. Relationship between Metabolic Rate, Free Radicals, Differentiation and Aging: A Unified Theory

      • R. S. Sohal, R. G. Allen
      Pages 75-104

    4. State of Knowledge on Action of Food Restriction and Aging

      • Edward Masoro
      Pages 105-116

    5. The Endocrine Response to Dietary Restriction in the Rat

      • B. J. Merry, Anne M. Holehan
      Pages 117-141

    6. Age Dependent Changes in Mitochondria

      • J. E. Fleming, J. Miquel, K. G. Bensch
      Pages 143-156

  4. Aging in Cellular Proteins

    1. Introductory Remarks—With Consideration of a T-Cell Model for Aging in Cellular Proteins

      • Takashi Makinodan, Timothy C. Fong, Tsutomu Inamizu, Mei-Ping Chang
      Pages 157-162

    2. Implications of 5′-Nucleotidase and its Inhibitor for Cellular Aging and Cancer

      • Alexander S. Sun, James F. Holland
      Pages 163-180

    3. The Effects of Dehydroepiandrosterone on the Rate of Development of Cancer and Autoimmune Processes in Laboratory Rodents

      • Arthur Schwartz
      Pages 181-191

    4. The Alteration of Enzymes in Aging Animals

      • Morton Rothstein
      Pages 193-204

    5. Differential and Similar Responses Between Rodent and Human Cells to DNA-Damaging Agents: Possible Implications for Cellular Aging

      • Jerry R. Williams, Peter D’Arpa, John Opishinski, Larry Dillehay, David Jacobson-Kram
      Pages 205-211

  5. Symposium Lecture - II

    1. Living All Your Life

      • Alex Comfort
      Pages 213-229

  6. Changes in DNA with Age - I

    1. Environmental and Genetic Factors that Influence Immunity and Longevity in Mice

      • D. J. Anderson, A. L. M. Watson, E. J. Yunis
      Pages 231-240

    2. Cellular Senescence: Factors Modulating Cell Proliferation In Vitro

      • Vincent J. Cristofalo, Paul D. Phillips, Katherine M. Brooks
      Pages 241-253

    3. Changes in Genetic Organization and Expression in Aging Cells

      • Samuel Goldstein, Arun Srivastava, Karl T. Riabowol, Robert J. Shmookler Reis
      Pages 255-267

  7. Changes in DNA with Age - II

    1. The Significance of DNA Methylation in Cellular Aging

      • Robin Holliday
      Pages 269-283

    2. DNA Manipulating Genes and the Aging Brain

      • Chev Kidson, Philip Chen, F. Paula Imray
      Pages 285-296

    3. In Vivo Studies on DNA Repair and Turnover with Age

      • Takatoshi Ishikawa, Junko Sakurai, Shozo Takayama
      Pages 297-313
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Keywords

About this book

It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore­ gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

Editors and Affiliations

  • Brookhaven National Laboratory, Upton, USA

    Avril D. Woodhead

  • University of Manchester Institute of Science and Technology, Manchester, UK

    Anthony D. Blackett

  • Council for Research Planning in Biological Sciences, Inc., USA

    Alexander Hollaender

Bibliographic Information

  • Book Title: Molecular Biology of Aging

  • Editors: Avril D. Woodhead, Anthony D. Blackett, Alexander Hollaender

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4899-2218-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1985

  • Hardcover ISBN: 978-0-306-42084-9Published: 31 October 1985

  • Softcover ISBN: 978-1-4899-2220-5Published: 21 June 2013

  • eBook ISBN: 978-1-4899-2218-2Published: 22 November 2013

  • Edition Number: 1

  • Number of Pages: XIV, 482

  • Topics: Psychology, general

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