Overview
- Editors:
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Jan-Michael Peters
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Research Institute of Molecular Pathology, Vienna, Austria
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J. Robin Harris
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Institute of Zoology, University of Mainz, Mainz, Germany
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Daniel Finley
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Harvard Medical School, Boston, USA
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Table of contents (15 chapters)
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- Martin Scheffner, Susan Smith, Stefan Jentsch
Pages 65-98
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- Keith D. Wilkinson, Mark Hochstrasser
Pages 99-125
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- Andrei Lupas, Wolfgang Baumeister
Pages 127-146
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- Jochen Beninga, Alfred L. Goldberg
Pages 191-222
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- A. Varshavsky, C. Byrd, I. V. Davydov, R. J. Dohmen, F. Du, M. Ghislain et al.
Pages 223-278
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- Mark Hochstrasser, Daniel Kornitzer
Pages 279-302
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- Zhijian J. Chen, Tom Maniatis
Pages 303-322
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- Jon M. Huibregtse, Carl G. Maki, Peter M. Howley
Pages 323-343
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- Jan-Michael Peters, Randall W. King, Raymond J. Deshaies
Pages 345-387
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- R. John Mayer, Michael Landon, James Lowe
Pages 429-462
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Back Matter
Pages 463-472
About this book
The last several years have been a landmark period in the ubiquitin field. The breadth of ubiquitin's roles in cell biology was first sketched, and the importance of ubiquitin-dependent proteolysis as a regulatory mechanism gained general acceptance. The many strands of work that led to this new perception are re counted in this book. A consequence of this progress is that the field has grown dramatically since the first book on ubiquitin was published almost a decade ago [M. Rechsteiner (ed. ), Ubiquitin, Plenum Press, 1988]. In this span, students of the cell cycle, transcription, signal transduction, protein sorting, neuropathology, cancer, virology, and immunology have attempted to chart the role of ubi quit in in their particular experimental systems, and this integration of the field into cell biology as a whole continues at a remarkable pace. We hope that for active researchers in the field as well as for newcomers and those on the fence, this book will prove helpful for its breadth, historical perspective, and practical tips. Structural data are now available on many of the components of the ubiquitin pathway. The structures have provided basic insights into the unusual biochemical mechanisms of ubiquitination and proteasome-mediated proteolysis. Because high-speed computer graphics can convey structures more effectively than print media, we have supplemented the figures of the book with a Worldwide Web site that can display the structures in a flexible, viewer-controlled format.
Editors and Affiliations
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Research Institute of Molecular Pathology, Vienna, Austria
Jan-Michael Peters
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Institute of Zoology, University of Mainz, Mainz, Germany
J. Robin Harris
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Harvard Medical School, Boston, USA
Daniel Finley
