New Concepts of a Blood—Brain Barrier

1. Front Matter

   Pages i-xi

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2. Developing Views of the Blood-Brain Barrier

   • Michael W. B. Bradbury

   Pages 1-9

3. Development of the Blood-Brain Barrier

   • Britta Engelhardt, Werner Risau

   Pages 11-31

4. Electrical Resistance Measurements of Blood-Brain Barrier Permeability

   • Arthur M. Butt

   Pages 33-38

5. The Application of Quantitative Immunocytochemistry for the Evaluation of Blood-Brain Barrier (BBB) to Endogenous Albumin

   • Andrzej W. Vorbrodt

   Pages 39-46

6. Endothelin as a Mediator of Blood-Brain Barrier Function

   • Maria Spatz, Danica Stanimirovic, Richard M. McCarron

   Pages 47-61

7. The Role of the Endothelial Cell Surface Charge for Blood-Brain Barrier Function

   • Barbro B. Johansson

   Pages 63-70

8. Capillary Permeability in Central and Peripheral Nerve Tissue in Streptozotocin Diabetes in the Anaesthetised Rat

   • G. G. Pinter, M. W. B. Bradbury

   Pages 71-73

9. Serotonin as a Mediator of Increased Microvascular Permeability of the Brain and Spinal Cord

   • H. S. Sharma, Y. Olsson, P. K. Dey

   Pages 75-80

10. Molecular Regulation of Blood-Brain Barrier GLUT1 Glucose Transporter

    • William M. Pardridge

    Pages 81-88

11. The Dependency of Influx Across the Blood-Brain Barrier on Blood Flow and the Apparent Flow-Independence of Glucose Influx During Stress

    • J. D. Fenstermacher, L. Wei, V. Acuff, S.-Z. Lin, J.-L. Chen, D. Bereczki et al.

    Pages 89-101

12. Brain-Blood Barrier Removal of DOPA: Role in Regulation of Dopamine Synthesis and Treatment of Parkinson’s Disease

    • Albert Gjedde, Jakob Reith, Gabriel Léger, Paul Cumming, Yoshifumi Yasuhara, Mark Guttman et al.

    Pages 103-109

13. Peptide Transport System-1

    • William A. Banks, Abba J. Kastin

    Pages 111-117

14. Long-Chain Fatty Acid Transport at the Blood-Brain Barrier and Incorporation into Brain Phospholipids: A New In Vivo Method for Examining Neuroplasticity, and Brain Second Messenger Systems Involving Phospholipase A₂ Activation

    • S. I. Rapoport, P. J. Robinson

    Pages 119-140

15. Haemostatic Functions of the Blood-Brain Barrier: Possible Implications in the Pathogenesis of Stroke

    • Berislav V. Zlokovic, Liang Wang, Steven S. Schreiber, Mark J. Fisher

    Pages 141-145

16. Autacoids as Mediators of Vasogenic Brain Oedema

    • M. Wahl, L. Schilling, A. Unterberg, A. Baethmann

    Pages 147-157

17. Blood-Brain Barrier Sodium Transport and Brain Edema Formation

    • A. Lorris Betz, Steven R. Ennis, Xiao-dan Ren, Gerald P. Schielke, Richard F. Keep

    Pages 159-168

18. Mechanisms and Control of Blood-Brain Potassium Transport

    • Richard F. Keep, Walter Stummer, Susan A. Klarr, Philip B. Furspan, A. Lorris Betz

    Pages 169-174

19. Transport of the Nucleoside, Thymidine, in the Central Nervous System: The Blood-Cerebrospinal Fluid and Blood-Brain Barriers

    • Sarah A. Williams, Hugh Davson, Malcolm B. Segal

    Pages 175-187

20. Nasal Cerebrospinal Fluid Drainage in Man

    • Pia Löwhagen, Barbro B. Johansson, Claes Nordborg

    Pages 189-194

The scientific contribution of Mike Bradbury to the study of the blood-brain barrier is considerable and wide-ranging, starting with his M.D. thesis in 1962 and still continuing today. The varied spectrum of topics relating to the blood-brain barrier presented in this volume and the many geographical locations from which both speakers and participants gathered to attend the symposium are a fitting testament both to Mike's wide-spread influence in the field and to the esteem in which he is held. When we first had the idea of afestschrift to mark Mike's retirement as Professor of Physiology at King's College London and the beginning of a new vie libre as scientist and yachtsman the plan was initially for a gathering of all of the many colleagues, collaborators and students who had worked with him over the years. However what we had not taken into account was the closeness of the international community of workers in the field, the widespread influence that Mike had wielded and the speed with which word would spread. We should have anticipated all three. The final outcome was an excellent symposium with the majority of the world's key workers either contributing or attending. We hope that this volume presents an adequate record of the meeting.

• Parkinson
• Transporter
• endothelium
• physiology
• tissue

• Institute of Ophthalmology, University College London, London, England

  John Greenwood

• King’s College, University of London, London, England

  David J. Begley

• United Medical and Dental Schools, St. Thomas’ Hospital, London, England

  Malcolm B. Segal

Policies and ethics