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Biological Reactive Intermediates V

Basic Mechanistic Research in Toxicology and Human Risk Assessment

  • Book
  • © 1996

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Editors:
  1. Robert Snyder

    1. Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, USA

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  2. I. Glenn Sipes

    1. University of Arizona, Tuscon, USA

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  3. David J. Jollow

    1. Medical University of South Carolina, Charleston, USA

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  4. Terrence J. Monks

    1. University of Texas, Austin, USA

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  5. James J. Kocsis

    1. Thomas Jefferson University, Philadelphia, USA

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  6. George F. Kalf

    1. Thomas Jefferson University, Philadelphia, USA

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  7. Helmut Greim

    1. GSF Institute of Toxicology, Technical University, Munich, Germany

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  8. Charlotte M. Witmer

    1. Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 387)

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Table of contents (55 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Session I

    1. New Biological Reactive Intermediates

      • Daniel Mansuy, Patrick M. Dansette
      Pages 1-6

    2. Activation of Toxic Chemicals by Cytochrome P450 Enzymes

      • F. Peter Guengerich, Yune-Fang Ueng, Bok-Ryang Kim, Sophie Langouet, Brian Coles, Rajkumar S. Iyer et al.
      Pages 7-15

    3. Investigating the Role of the Microsomal Epoxide Hydrolase Membrane Topology and Its Implication for Drug Metabolism Pathways

      • Thomas Friedberg, Bettina Löllmann, Roger Becker, Romy Holler, Michael Arand, Franz Oesch
      Pages 17-24

    4. Cytotoxicity of Nitric Oxide and Hydrogen Peroxide

      • Iosif Ioannidis, Thomas Volk, Herbert de Groot
      Pages 25-30

    5. Development of a Mass Spectrometric Assay for 5,6,7,9-Tetrahydro-7-Hydroxy-9-Oximidazo [1,2-a]Purine in DNA Modified by 2-Chloro-Oxirane

      • Michael Müller, Frank Belas, Hitoshi Ueno, F. Peter Guengerich
      Pages 31-36

  3. Session II

    1. Reactions of Reactive Metabolites with Hemoproteins—Toxicological Implications

      • Yoichi Osawa, Kashime Nakatsuka, Mark S. Williams, James T. Kindt, Mikiya Nakatsuka
      Pages 37-45

    2. Immunochemical Detection of Drug-Protein Adducts in Acetaminophen Hepatotoxicity

      • Jack A. Hinson, Dean W. Roberts, N. Christine Halmes, Jennifer D. Gibson, Neil R. Pumford
      Pages 47-55

    3. An Oxidant Sensor at the Plasma Membrane

      • Axel Knebel, Mihail Iordanov, Hans J. Rahmsdorf, Peter Herrlich
      Pages 57-62

    4. Identification of Hydrogen Peroxide as the Relevant Messenger in the Activation Pathway of Transcription Factor NF-κB

      • Kerstin N. Schmidt, Paul Amstad, Peter Cerutti, Patrick A. Baeuerle
      Pages 63-68

    5. Redox Regulation of Ap-1

      • Steven Xanthoudakis, Tom Curran
      Pages 69-75

    6. The Transcription Factor TCF/Elk-1

      • Judith M. Müller, Michael A. Cahill, Alfred Nordheim, Patrick A. Baeuerle
      Pages 77-84

  4. Session III

    1. Some Activities of the Oxidant Chromate

      • Hyoung-Sook Park, Sean O’Connell, Saul Shupack, Edward Yurkow, Charlotte M. Witmer
      Pages 85-96

    2. Reactive Dopamine Metabolites and Neurotoxicity

      • Teresa G. Hastings, David A. Lewis, Michael J. Zigmond
      Pages 97-106

    3. Selective Depletion of Mitochondrial Glutathione Content by Pivalic Acid and Valproic Acid in Rat Liver

      • U. Zanelli, P. Puccini, D. Acerbi, P. Ventura, P. G. Gervasi
      Pages 107-111

    4. Regulation of the Superoxide Releasing System in Human Fibroblasts

      • Beate Meier
      Pages 113-116

    5. Studies on the Mechanism of Phototoxicity of BAY y 3118 and Other Quinolones

      • U. Schmidt, G. Schlüter
      Pages 117-120

    6. 4-Oxo-Retinoic Acid Is Generated from Its Precursor Canthaxanthin and Enhances Gap Junctional Communication in 10T1/2 Cells

      • Wilhelm Stahl, Michael Hanusch, Helmut Sies
      Pages 121-128

    7. Hepatic Epoxide Concentrations during Biotransformation of 1,2- and 1,4-Dichlorobenzene

      • Erna Hissink, Ben van Ommen, Jan J. Bogaards, Peter J. van Bladeren
      Pages 129-133

    8. Oxygen Radical Formation Due to the Effect of Varying Hydrogen Ion Concentrations on Cytochrome P450-Catalyzed Cyclosporine Metabolism in Rat and Human Liver Microsomes

      • S. Sohail Ahmed, Kimberly L. Napoli, Henry W. Strobel
      Pages 135-139
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Keywords

About this book

Much of organic chemistry is based on the ability of suitably structured chemicals to bind together through the formation of covalent bonds. Biochemistry is replete with exam­ ples of enzymatically catalyzed reactions in which normal body constituents can be linked through covalent bonds during the process of intermediary metabolism. The finding that xenobiotic chemicals that enter the body from the environment, are metabolized to highly reactive species, and then covalently react with cellular macromolecules to induce toxic and carcinogenic effects was an observation that spawned the research featured in the Fifth International Symposium on Biological Reactive Intermediates (BRI V). The group of investigators that became fascinated with this process and its signifi­ cance in terms of human health began their discussions in Turku, Finland (J 975), and continued them at Guildford, England (1980), College Park, Maryland (1985), Tucson, Arizona (1990), and Munich, Germany (1995). Among the results were a series of reports listed below, as well as the book for which this serves as the Preface. • Jollow, DJ., Kocsis, J.J., Snyder, R. and Vainio, H. (eds), Biological Reactive Intermediates: Formation, Toxicity and Inactivation, Plenum Press, NY, 1975. • Snyder, R., Park, D.V., Kocsis, J.J., Jollow, D.V., Gibson, G.G. and Witmer, C.M. (eds), Biological Reactive Intermediates II: Chemical Mechanisms and Biological Effects, Plenum Press, N.Y., 1982.

Editors and Affiliations

  • Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, USA

    Robert Snyder, Charlotte M. Witmer

  • University of Arizona, Tuscon, USA

    I. Glenn Sipes

  • Medical University of South Carolina, Charleston, USA

    David J. Jollow

  • University of Texas, Austin, USA

    Terrence J. Monks

  • Thomas Jefferson University, Philadelphia, USA

    James J. Kocsis, George F. Kalf

  • GSF Institute of Toxicology, Technical University, Munich, Germany

    Helmut Greim

Bibliographic Information

  • Book Title: Biological Reactive Intermediates V

  • Book Subtitle: Basic Mechanistic Research in Toxicology and Human Risk Assessment

  • Editors: Robert Snyder, I. Glenn Sipes, David J. Jollow, Terrence J. Monks, James J. Kocsis, George F. Kalf, Helmut Greim, … Charlotte M. Witmer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-9480-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1996

  • Hardcover ISBN: 978-0-306-45197-3Published: 30 June 1996

  • Softcover ISBN: 978-1-4757-9482-3Published: 26 June 2013

  • eBook ISBN: 978-1-4757-9480-9Published: 21 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIV, 462

  • Topics: Oncology, Pharmacology/Toxicology, Biochemistry, general

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