Cancer Gene Therapy

1. Front Matter

   Pages i-xiv

   PDF

2. The Clinical Problem

   1. Management Problems in Oncology

      • Susan J. Cleator, Pat Price

      Pages 3-10

3. Vectors

   1. Adenoviral Vectors

      • Prem Seth

      Pages 13-22

   2. Retrovirus Vectors

      • Yasuhiro Takeuchi, Massimo Pizzato

      Pages 23-35

   3. Targetable Gene Delivery Vectors

      • Paul L. Hallenbeck, Susan C. Stevenson

      Pages 37-46

   4. Human α-fetoprotein Transcriptional Regulatory Sequences

      • Taiki Tamaoki

      Pages 47-56

   5. Tumor-Targeted Salmonella

      • David Bermudes, Brooks Low, John Pawelek

      Pages 57-63

   6. Mutant Adenoviruses Selectively Replication-Competent in Tumor Cells

      • Makoto Sunamura

      Pages 65-71

   7. Polyoma and Papilloma Virus Vectors For Cancer Gene Therapy

      • Nina Krauzewicz, Beverly E. Griffin

      Pages 73-82

   8. Cochleates

      • Leila Zarif, Raphael J. Mannino

      Pages 83-93

   9. The Use Of Skeletal Muscle To Express Genes For The Treatment Of Cancer

      • Stephen Coe, Michael Harron, Marc Winslet, Geoffrey Goldspink

      Pages 95-111

4. Cell Cycle Control

   1. Adhesion Molecules in Cancer Biology

      • Yaw Ohene-Abuakwa, Massimo Pignatelli

      Pages 115-126

   2. Cell Cycle Control

      • Vivien J. Tannoch, Phil W. Hinds, Li-Huei Tsai

      Pages 127-140

5. Apoptosis

   1. Killer/DR5, A Novel DNA-Damage Inducible Death Receptor Gene, Links the p53-Tumor Suppressor to Caspase Activation and Apoptotic Death

      • Gen Sheng Wu, Kunghong Kim, Wafik S. El-Deiry

      Pages 143-151

   2. Apoptin®

      • Alexandra Pietersen, Mathieu H. M. Noteborn

      Pages 153-161

   3. Adenovirus-Mediated Herpes Simplex Thymidine Kinase Gene Therapy For Brain Tumors

      • Anu-Maaria Sandmair, Matti Vapalahti, Seppo Ylä-Herttuala

      Pages 163-170

   4. Development of Clinical Trial of E1A Gene Therapy Targeting HER-2/neu-overexpressing Breast and Ovarian Cancer

      • M. C. Hung, Hortobagyi G. N., N. T. Ueno

      Pages 171-180

6. Tumout Suppressor Genes

   1. Pre-clinical Studies with Tumor Suppressor Genes

      • Prem Seth

      Pages 183-192

   2. Gene Therapy for Liver Tumours

      • Ragai R. Mitry, Marc R. Mansour, Roman Havlik, Nagy A. Habib

      Pages 193-205

   3. Adenovirus-mediated Transfer of a p53 Gene in Ovarian Cancer

      • Junzo Kigawa, Naoki Terakawa

      Pages 207-214

With the coming of the new millennium we are witnessing a revolution in our understanding of cancer genetics. These are very exciting times. Today we have at our disposal the technology to diagnose abnormalities in our cancer genes and the means to correct the deficit and very soon we will have the complete sequence of the human genome. With the use of gene chip technology the way doctors will be able to assess patients will change completely. Today we can diagnose abnormalities in ten thousand genes and within a short period of time we will be able to screen through our genome and discover potential abnormalities in our proto-oncogenes, tumour suppressor genes, differentiating genes, apoptotic genes and pro-inflammatory genes. In this book various authors have highlighted specific genes that could be expressed, overexpressed, neutralised or h- nessed to achieve cancer control. The problem of transferring the therapeutic gene into the cancer cell has been partly addressed with major developments in the field of naked plasmid DNA, adenovirus, retrovirus and adeno-associated viruses. However, further improvements are yet to be made to achieve significant gene transfer. Gene expression, in particular specificity of gene transfer, is obviously an important issue and one which is highlighted in this book by the use of specific promoter.

• apoptosis
• development
• gene therapy
• genes
• transcription

• Imperial College School of Medicine, Hammersmith Hospital, London, UK

  Nagy A. Habib

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