Pseudocarcinoma of the Skin

1. Front Matter

   Pages i-xiii

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2. Historical Background, Terminology, and Classification

   • B. A. Berenbein

   Pages 1-11

3. Factors Predisposing to Pseudocarcinomatous Hyperplasia and to Malignant Transformation of the Epidermis

   • B. A. Berenbein

   Pages 12-27

4. Clinicopathologic Characteristics of Pseudocarcinomatous Epidermal Hyperplasia and of Squamous Cell Carcinoma

   • B. A. Berenbein

   Pages 28-66

5. Mitotic Behavior of Epidermal Cells in Pseudocarcinomatous Hyperplasia and in Squamous Cell Carcinoma

   • B. A. Berenbein

   Pages 67-82

6. The DNA Content of Epidermal Cell Nuclei in Pseudocarcinomatous Hyperplasia and in Squamous Cell Carcinoma

   • B. A. Berenbein

   Pages 83-95

7. Cytophysiologic and Cytogenetic Characteristics of Epidermal Cells in Pseudocarcinomatous Hyperplasia and in Squamous Cell Carcinoma

   • B. A. Berenbein

   Pages 96-133

8. Regulation of Epidermal Proliferation

   • B. A. Berenbein

   Pages 134-141

9. Skin Diseases with Obligatory Development of Pseudocarcinomatous Hyperplasia

   • B. A. Berenbein

   Pages 142-169

10. Skin Diseases with Facultative Development of Pseudocarcinomatous Hyperplasia

    • B. A. Berenbein

    Pages 170-205

11. Criteria for Diagnostic Differentiation Between Pseudocarcinomatous Epidermal Hyperplasia and Squamous Cell Carcinoma of the Skin

    • B. A. Berenbein

    Pages 206-212

12. Management and Prevention of Cutaneous Pseudocarcinoses

    • B. A. Berenbein

    Pages 213-223

13. Back Matter

    Pages 224-263

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Among the circumstances that may cause a too late or erroneous diagnosis of skin cancer, a most important one is the failure to distinguish a true squamous cell carcinoma of the skin from an atypical, but benign, epidermal hyperplasia which closely mimics the carcinoma clinically and particularly histologically - so-called pseudoepitheliomatous or pseudocarcinomatous hyperplasia. Although there are many publications describing in detail the histologic features of pseudocarcinomatous hyperplasias which arise in various dermatoses or skin tumors, this book appears to be the first attempt to cover the whole subject of pseudocarcinomatous epidermal hyperplasia by considering it not only in its clinical and histopathologic aspects, but also from cytophysiologic and cytogen­ etic points of view, in relation to squamous cell carcinoma. On the basis of a review of the available literature and of my own correlative clinical, histopathologic, cytophysiologic, and cytogenetic investigations in patients and experimental animals, I propose a comprehensive set of criteria of difference and similarity between pseudocarcinoma and true carcinoma of the skin. Hopefully, these criteria will be found useful by physicians in the differential diagnosis between these conditions in cases of doubt and may likewise provide a stimulus to researchers for deliberation. I also hope that this monograph, which is a translation of a revised version of the text originally published in Russian in 1980, will serve our common cause of the fight against cancer. I welcome suggestions regarding the choice and treatment of the material included in the book.

• cancer
• carcinoma
• cell
• skin cancer

• Moscow Regional Institute for Clinical Research, Moscow, USSR

  B. A. Berenbein

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