Molecular Aspects of Development and Aging of the Nervous System

1. Front Matter

   Pages i-ix

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2. Gene and Phenotypic Expression

   1. Transient Induction of Gene Expression in the Nervous System in Response to Extracellular Signals

      • Harvey R. Herschman

      Pages 1-9

   2. Developmental Regulation of Myelin-Associated Genes in the Normal and the Myelin Deficient Mutant Rat

      • M. N. Gordon, S. Kumar, A. Espinosa de los Monteros, S. Scully, M.-S. Zhang, J. Huber et al.

      Pages 11-22

   3. Analysis of Glial Scarring in the Mammalian CNS with a GFAP cDNA Probe

      • Pierre Rataboul, Philippe Vernier, Alain Privat

      Pages 23-40

   4. Regulation of the Glial Fibrillary Acidic Protein (GFAP) and of its Encoding mRNA in the Developing Brain and in Cultured Astrocytes

      • M. Tardy, C. Fages, G. Le Prince, B. Rolland, J. Nunez

      Pages 41-52

   5. Cell Lineage Studies in Avian Neural Crest Ontogeny

      • Anne Baroffio, Elisabeth Dupin, Nicole M. Le Douarin

      Pages 53-62

3. Growth Factors and Oncogenes

   1. Characterization of Trophic Factors Stored and Secreted by Neurons

      • K. Unsicker, D. Blottner, D. Gehrke, C. Grothe, D. Heymann, F. Stögbauer et al.

      Pages 63-73

   2. Neuropeptides as Positive or Negative Neuronal Growth Regulatory Factors: Effects of Acth and Leu-Enkephalin on Cultured Serotonergic Neurons

      • Martha I. Davila-Garcia, Efrain C. Azmitia

      Pages 75-92

   3. Basic Fibroblast Growth Factor Affects the Survival and Development of Mesencephalic Neurons in Culture

      • Giovanna Ferrari, Maria-Cristina Minozzi, Gino Toffano, Alberta Leon, Stephen D. Skaper

      Pages 93-99

   4. Role of Trophic Factors in Neuronal Aging

      • J. Regino Perez-Polo

      Pages 101-116

   5. Localization of the Normal Cellular SRC Protein to the Growth Cone of Differentiating Neurons in Brain and Retina

      • Patricia F. Maness, Carol G. Shores, Michael Ignelzi

      Pages 117-125

   6. A Role of Ras Oncogenes in Carcinogenesis and Differentiation

      • Demetrios A. Spandidos, Margaret L. M. Anderson

      Pages 127-131

   7. Neuronal Localization of the Nerve Growth Factor Precursor-Like Immunoreactivity in the Cortex and Hippocampus of the Rat Brain

      • Marie-Claude Senut, Yvon Lamour, Philippe Brachet, Eleni Dicou

      Pages 133-139

   8. Development of NILE Glycoprotein in Chick Brain

      • Anna Batistatou, Elias D. Kouvelas

      Pages 141-146

4. Cytoskeletal and Extracellular Molecules

   1. Structural and Molecular Polarity in Retinal Photoreceptor Neurons: Roles for the Cytoskeleton

      • Ruben Adler, Steven A. Madreperla

      Pages 147-156

   2. Matrix Interactions Regulating Myelinogenesis in Cultured Oligodendrocytes

      • Leonard H. Rome, Michael C. Cardwell, Phyllis N. Bullock, Steven P. Hamilton

      Pages 157-167

   3. Cerebellar Granule Cell Migration Involves Proteolysis

      • Nicholas W. Seeds, Susan Haffke, Kathleen Christensen, Judith Schoonmaker

      Pages 169-178

   4. Neural Cell Adhesion Molecule as a Regulator of Cell-Cell Interactions

      • Urs Rutishauser

      Pages 179-183

   5. Structure and Function of the Neural Cell Adhesion Molecules NCAM and L1

      • Ole Nybroe, Elisabeth Bock

      Pages 185-196

   6. Monosialogangliosides and Their Action in Modulating Neuroplastic Behaviors of Neuronal Cells

      • Stephen D. Skaper, Guido Vantini, Laura Facci, Alberta Leon

      Pages 197-204

The rapidly expanding fields of molecular and cellular neurobiology are the newest frontiers of neuroscience. This book represents the continuing efforts of the Institute of Developmental Neuroscience and Aging (IDNA) to disseminate the most recent advances on the developing and aging nervous system at the molecular and cellular levels. A group of neuroscientists presented and discussed their findings at a recent IDNA conference held in Athens, Greece, June 15-18, 1988. This meeting was sponsored by the National Hellenic Research Foundation, FIDIA, the Ministry of Research and Technology, the Tourism Organization of Greece, and the National Institute of Child Health and Human Development, NIH. The Directors of the IDNA are grateful to the local committee, Drs. Eleni Fleischer, Costas Sekeris, Michael Alexis, Theony Valcana, and Elias Kouvelas, for their efforts in organizing this meeting and for their successful integration of science and culture for the participants. This volume provides a comprehensive overview of the information presented at this conference, including in-depth discussions of each topic by the participants. The chapters are grouped into five general categories which correspond to the subject areas covered during the meeting. These include: Gene and Phenotypic Expression, Growth Factors and Oncogenes, Cytoskeletal and Extracellular Molecules, Neurotransmitters and Hormones, and Molecular Aspects of Aging and Alzheimer's Disease. The section on Gene and Phenotypic Expression includes discussions of transient gene expression in the nervous system (Herschman), developmental regulation of myelin-associated genes (Gordon et al.

• Alzheimer's disease
• Alzheimer´s disease
• brain
• development
• growth
• myelin
• nervous system
• neurobiology
• neurons
• neuropeptides
• neuroscience
• organization
• research
• science
• spinal cord

• The University of North Carolina School of Medicine, Chapel Hill, USA

  Jean M. Lauder

• Institute of Biology, INSERM, Montpellier, France

  Alain Privat

• Southern Illinois University School of Medicine, Springfield, USA

  Ezio Giacobini

• University of California, Berkeley, USA

  Paola S. Timiras

• University of Colorado School of Medicine, Denver, USA

  Antonia Vernadakis

Policies and ethics