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Cell Impairment in Aging and Development

  • Book
  • © 1975

Overview

Editors:
  1. Vincent J. Cristofalo

    1. Wistar Institute of Anatomy and Biology, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Emma Holečková

    1. Institute of Physiology, Czechoslovak Academy of Sciences, Prague 4, Czechoslovakia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 53)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xv
    Download chapter PDF

  2. Cell Ageing: Chairman’s Introduction

    • L. M. Franks
    Pages 1-5

  3. The Effect of Hydrocortisone on DNA Synthesis and Cell Division during Aging in Vitro

    • V. J. Cristofalo
    Pages 7-22

  4. Proliferative and Functional Impairment of Pancreatic Epithelial Cells Maintained in Vitro

    • Robert J. Hay
    Pages 23-39

  5. The Use of Arrested Populations of Human Diploid Fibroblasts for the Study of Senescence in Vitro

    • Robert T. Dell’Orco
    Pages 41-49

  6. Relationship between Cell Kinetic Changes and Metabolic Events during Cell Senescence in Vitro

    • A. Macieira-Coelho, E. Loria, L. Berumen
    Pages 51-65

  7. Do Hyperplastoid Cell Lines “Differentiate Themselves to Death”?

    • G. M. Martin, C. A. Sprague, T. H. Norwood, W. R. Pendergrass, P. Bornstein, H. Hoehn et al.
    Pages 67-90

  8. Time-Lapse Cinemicrophotographic Studies of Cell Division Patterns of Human Diploid Fibroblasts (WI-38) during their in Vitro Lifespan

    • P. Marlene Absher, Richard G. Absher, William D. Barnes
    Pages 91-105

  9. Characteristics of Proliferative Cells from Young, Old, and Transformed WI 38 Cultures

    • Phillip D. Bowman, Charles W. Daniel
    Pages 107-122

  10. Alterations in Chromatin Functions during Aging in Vitro

    • Jon M. Ryan
    Pages 123-136

  11. Growth-Promoting Alpha-Globulin and Ageing

    • Jiří Michl, Mirosalv Tolar, Věra Spurná, Dagmar Řezáčová
    Pages 137-146

  12. Cell Surface Alterations and “in Vitro” Aging of Animal Cells

    • R. Azencott, C. Hughes, Y. Courtois
    Pages 147-153

  13. Changes in Lysosomes during Ageing of Parenchymal and Non-Parenchymal Liver Cells

    • D. L. Knook, E. C. Sleyster, M. J. van Noord
    Pages 155-169

  14. The Effect of Age on Mitochondrial Ultrastructure and Enzymes

    • P. D. Wilson, L. M. Franks
    Pages 171-183

  15. Creatinephosphokinase in Human Diploid Cell Lines

    • M. Macek, H. Tomášová, J. Hurych, D. Řezáčová
    Pages 185-192

  16. Cytochemical and Cytogenetic Findings in Five Human Leukocyte Long-Term Cultures (LAHL) of Different Origin

    • V. Pössnerová, M. Macek, F. Heřmanský, J. Fortýnová, S. Jeník, J. Holý et al.
    Pages 193-205

  17. Enzymatic Differences between Short-Lived and Long-Lived Drosophila Strains

    • Jaroslava Skřivanová, Františka A. Gadirová, Emma Holečková
    Pages 207-213

  18. Cell Ageing in the Intestinal Tract

    • C. Rowlatt
    Pages 215-217

  19. Studies on the Proliferative Capacity of Mouse Spleen Cells in Serial Transplantation

    • J. W. I. M. Simons, C. van den Broek
    Pages 219-233

  20. On the Ageing of Intermitotic Cells — Investigations on Enterocytes and Hepatocytes

    • G. Leutert, W. Rotzsch, W. Beier
    Pages 235-245
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Keywords

About this book

lar aging, to which this model contributes, has grown. Apart from reports on work in this almost "classical" diploid cell system, the symposium presents studies using different biological systems with results that have been rewarding as information is obtained on patterns of change that are common to more than one experimental system. Indeed, in recent years much more has been learned about the fate of all different types of intermitotic and postmitotic cells in situ. The symposium has also presented contributions dealing, not directly with aging but with early ontogeny; such information on early developmental changes should certainly shed light on some of the mechanisms involved in aging. We are cognizant of the fact that environmental influences resulting from the complexities of modern civilization may have results that only occur much later, and profoundly affect the lifespan of the organism. There remain, of course, many unanswered questions. Whether there is "physiological" as opposed to "pathological" aging; whether "old" cultures living in unchanged, although not exhausted, medium, are degenerating, not aging; what is involved when "old" fragment cultures regenerate after excision by filling the wound with "young" cells; why some tumor cells in vivo as well as in vitro die while others live; all are questions~eserving of our attention.

Editors and Affiliations

  • Wistar Institute of Anatomy and Biology, Philadelphia, USA

    Vincent J. Cristofalo

  • Institute of Physiology, Czechoslovak Academy of Sciences, Prague 4, Czechoslovakia

    Emma Holečková

Bibliographic Information

  • Book Title: Cell Impairment in Aging and Development

  • Editors: Vincent J. Cristofalo, Emma Holečková

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4757-0731-1

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1975

  • Softcover ISBN: 978-1-4757-0733-5Published: 22 March 2013

  • eBook ISBN: 978-1-4757-0731-1Published: 11 November 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XV, 557

  • Number of Illustrations: 172 b/w illustrations

  • Topics: Anatomy

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