Colonic Diseases

1. Front Matter

   Pages i-xviii

   PDF

2. Colorectal Physiology

   1. Front Matter

      Pages 1-1

      PDF

   2. Absorption—Secretion and Epithelial Cell Function

      • Pradeep K. Dudeja, Ravinder Gill, K. Ramaswamy

      Pages 3-23

   3. Normal Motility and Smooth Muscle Function

      • Mary Francis Otterson

      Pages 25-33

   4. Neural Regulation of Colonic Motor Function

      • Kenton M. Sanders, Terence K. Smith

      Pages 35-52

   5. Mucin and Goblet Cell Function

      • Samuel B. Ho, Laurie L. Shekels

      Pages 53-71

   6. Endocrine Cells of the Colon

      • Sebastian G. de la Fuente, Christopher R. Mantyh, Theodore N. Pappas

      Pages 73-84

   7. Micronutrients

      • Emmanuel C. Opara

      Pages 85-93

   8. Aging

      • Emmanuel C. Opara, Timothy R. Koch

      Pages 95-104

   9. Immunology of the Gastrointestinal Tract

      • Jonathan R. Fulton, Cynthia A. Cunningham, Christopher F. Cuff

      Pages 105-122

   10. Colonic Lymphatics

       • Stacey A. Weiland, Yang K. Chen

       Pages 123-140

   11. Probiotics and the Colon

       • Thomas J. Borody, Patricia L. Conway

       Pages 141-161

   12. Physiology and Pathophysiology of Colorectal Sensory Processes

       • Michael D. Crowell, Brian E. Lacy

       Pages 163-175

3. Investigation of Disease Processes

   1. Front Matter

      Pages 177-177

      PDF

   2. Oxidative Stress

      • Emmanuel C. Opara

      Pages 179-189

   3. Genetic Testing for Colon Cancer

      • Russell F. Jacoby, Carolyn E. Cole

      Pages 191-210

   4. Inflammation

      • Cynthia A. Cunningham, Jonathan R. Fulton, Christopher F. Cuff

      Pages 211-225

   5. Epidemiologic Studies and Outcomes Research in Colonic Diseases

      • John F. Johanson

      Pages 227-242

   6. Colonoscopy

      • Donald G. Seibert

      Pages 243-274

   7. Interpretation of Colonic Biopsies in Patients with Diarrhea

      • Sarah M. Dry, Galen R. Cortina, Klaus J. Lewin

      Pages 275-295

The Scientification of Gastroenterology During the 20th Century * Science contributes to medicine in three ways: It provides a body of relatively secure knowl­ edge. Some of that knowledge has been applied to develop technologies which have had a major impact upon the practice and effectiveness of medicine. Last, science offers to medicine a way of thinking. - 1. McCormick [(1993) The Contribution of Science to Medicine. Perspect. Bioi. Med. 16,315.] Awareness of the digestive system began with the dawn of civilization, when man, observing the feeding habits of animals in the surrounding environment, experimented with foods, edible and inedible. Identity came with discoveries of the digestive organs during the 16th and 17th centuries. Function was revealed by physiologic studies of digestion, absorp­ tion and secretion, metabolism, and motility during the 18th and 19th centuries. Diagnostic access improved with the technological advances of the 20th century. Understanding of gas­ trointestinal (GI) disease followed the growth of the basic sciences and gastroenterology's involvement in scientific research during the latter half of the 20th century. Early in the 20th century, gastroenterology was yet an undefined activity without clinical or scientific guidelines. Diagnostic approach to the digestive tract was minimal. Valid con­ cepts of disease were lacking. Visceroptosis, sitophobia, and "colonic autointoxication" were common "diagnoses." Therapeutic resources were scarce.

• biopsy
• cancer
• colon
• colorectal cancer
• gastrointestinal tract
• imaging
• immunology
• inflammation
• muscle
• pathophysiology
• physiology

"...recommended for use by trainee clinician-scientists and by basic scientists who desire a perspective on their work-a bridge between basic and clinical research...an attractive, high-quality production, well illustrated and comprehensively referenced...refreshingly manageable, easy to read, and generally filled with useful information." - New England Journal of Medicine

"The book contains brief, generally well-written chapters surveying a wide range of topics of interest to most gastroenterologists. Dedicated chapters not found in most gastoenterology textbooks include coverage of aging and the gastrointestinal tract and the interpretation of colonic biopsy specimens in patients with diarrhea." - American College of Physicians

"Valuable reading for gastroenterologists interested in bridging the gap between basic and clinical research and disease processes in the continuously changing field of coloni c disorders." - Digestive and Liver Disease

"...this textbook has its greatest value for those interested in the basics of colonic morphology and function...Chapters on anorectal and colonic motility studies are probably among the best I have ever read on these subjects." - Practical Gastroenterology

"The book is well organized and written clearly with many references helpful to the reader seeking additional knowledge on the subject. This book is mostly intended for gastroenterologists, gastrointestinal fellows, all specialist physicians including radiologists and family physicians who daily treat gastrointestinal disorders." - Journal of Clinical Imaging

• Division of Gastroenterology and Hepatology, Medical College of Wisconsin, Milwaukee, USA

  Timothy R. Koch

Policies and ethics