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Signaling Networks and Cell Cycle Control

The Molecular Basis of Cancer and Other Diseases

  • Book
  • © 2000

Overview

Editors:
  1. J. Silvio Gutkind

    1. Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA

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Part of the book series: Cancer Drug Discovery and Development (CDD&D)

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Table of contents (32 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Integrin Signaling

    • Kenneth M. Yamada, Erik H. J. Danen
    Pages 1-25

  3. Signal Transduction Through Tyrosine Kinase Growth Factor Receptors

    • Paolo Fedi, Stuart A. Aaronson
    Pages 27-38

  4. Signaling from TGF-β Receptors

    • Anita B. Roberts, Mark P. de Caestecker, Robert J. Lechleider
    Pages 39-51

  5. The Wnt Signal Transduction Pathway

    • Grant D. Barish, Bart O. Williams
    Pages 53-82

  6. Signaling from G-Protein-Coupled Receptors to the Nucleus

    • Shigetomo Fukuhara, Maria Julia Marinissen, Mario Chiariello, J. Silvio Gutkind
    Pages 83-98

  7. Proximal Events in T-Cell Activation

    • Joanne Sloan-Lancaster, Lawrence E. Samelson
    Pages 99-111

  8. Signal Transduction from the High Affinity IgE Receptor

    • Reuben P. Siraganian
    Pages 113-134

  9. Signaling Through Fas (CD95, APO-1) and Related Death Receptors

    • Richard M. Siegel, David A. Martin, Felicita Hornung, Erastus C. Dudley, Lixin Zheng, Michael J. Lenardo
    Pages 135-152

  10. Signal Transduction to the Nucleus by MAP Kinase

    • Roger J. Davis
    Pages 153-164

  11. The Regulation of MAP Kinase Pathways by MAP Kinase Phosphatases

    • Kathleen Kelly, Yanfang Chu
    Pages 165-182

  12. Control of MAPK Signaling by Ste20- and Ste11-Like Kinases

    • Gary R. Fanger, Thomas K. Schlesinger, Gary L. Johnson
    Pages 183-211

  13. Ras Signaling and Transformation

    • Geoffrey J. Clark, John P. O’Bryan, Channing J. Der
    Pages 213-230

  14. Signaling Pathways Controlled by Rho Family GTP-Binding Proteins

    • Marc Symons
    Pages 231-245

  15. PI3-Kinases

    • David A. Fruman, Lewis C. Cantley
    Pages 247-266

  16. PI3K-Related Kinases

    • Randal S. Tibbetts, Robert T. Abraham
    Pages 267-301

  17. Integrative Signaling Through c-Abl

    • Jean Y. J. Wang
    Pages 303-324

  18. Src

    • Pamela L. Schwartzberg
    Pages 325-345

  19. Inhibitors of Protein Kinase C and Related Receptors for the Lipophilic Second-Messenger sn-1,2-Diacylglycerol

    • Peter M. Blumberg, Peter Acs, Dipak K. Bhattacharyya, Patricia S. Lorenzo
    Pages 347-364

  20. Reactive Oxygen Species in Proliferative Signaling

    • Toren Finkel, Daniel M. Sullivan
    Pages 365-377
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Keywords

About this book

Leading scientists summarize the latest findings on signal transduction and cell cycle regulation and describe the effort to design and synthesize inhibiting molecules, as well as to evaluate their biochemical and biological activities. They review the relevant cell surface receptors, their ligands, and their downstream pathways. Also examined are the latest findings on the components of novel signaling networks controlling the activity of nuclear transcription factors and cell cycle regulatory molecules. Cutting-edge and highly suggestive, Signaling Networks and Cell Cycle Control: The Molecular Basis of Cancer and Other Diseases presents a wealth of information on the emerging principles of the field, as well as an invaluable guide for all experimental and clinical investigators of cell regulation and its rapidly emerging pharmacological opportunities today.

Reviews

"Each chapter contains a well-referenced, clearly illustrated and up-to-date summary of the state of affairs including a discussion of the areas that are still open for further work. The volume provides a good read for both workers actively engaged in drug research as well as those working in the more fundamental areas of signaling and the cell cycle." - Cell Biology and Function

"...the range of topics included in this book is impressive....This volume works well on many levels. For graduate students struggling to assimilate the large body of signaling literature, the first half of the book offers what amounts to a comprehensive review of the most basic aspects of signal transduction. For experts, these same chapters serve as a point of departure for the second half, which deals with the emerging body of literature on how one can manipulate signaling pathways in the treatment of disease. It is the combination of basic and applied aspects of signal transduction that makes this book unique....the editor has done a remarkable job in selecting and assembling reviews from experts in signal transduction, and for presenting such a lucid discussion of this complex field." - Quarterly Review of Biology

"Each chapter is well referenced and stands alone as a comprehensive review in a specific area of signaling networks and cell-cycle control. In many cases the authors have highlighted several areas that are still open for further investigation, and have attempted to define the most likely molecular targets for pharmacological intervention...I would recommend this as a must have reference book, aimed mainly at an expert audience, which any good academic or biotechnological company library should have." - Cell Biology International

Editors and Affiliations

  • Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, USA

    J. Silvio Gutkind

Bibliographic Information

  • Book Title: Signaling Networks and Cell Cycle Control

  • Book Subtitle: The Molecular Basis of Cancer and Other Diseases

  • Editors: J. Silvio Gutkind

  • Series Title: Cancer Drug Discovery and Development

  • DOI: https://doi.org/10.1007/978-1-59259-218-0

  • Publisher: Humana Totowa, NJ

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 2000

  • Hardcover ISBN: 978-0-89603-710-6Published: 14 April 2000

  • Softcover ISBN: 978-1-4684-9695-6Published: 23 July 2012

  • eBook ISBN: 978-1-59259-218-0Published: 14 April 2000

  • Series ISSN: 2196-9906

  • Series E-ISSN: 2196-9914

  • Edition Number: 1

  • Number of Pages: XIV, 578

  • Number of Illustrations: 97 b/w illustrations

  • Topics: Pharmacy

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