Cerebral Sinus Thrombosis

1. Front Matter

   Pages i-viii

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2. Structural and Functional Basis

   1. Front Matter

      Pages 1-1

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   2. Histomorphology and Ultrastructure of the Cerebro-Venous System

      • W. Roggendorf

      Pages 3-14

   3. Neuropathological Findings in the Thrombosis of Cerebral Veins and Sinuses: Vascular Aspects

      • J. Cervos-Navarro, S. Kannuki

      Pages 15-25

   4. Thrombosis of Cranial Veins and Sinuses: Brain Parenchymal Effects

      • J. H. Garcia

      Pages 27-38

   5. A New Experimental Model of Sinus Vein Thrombosis

      • M. Deckert, K. Frerichs, P. Mehraein, O. Kempski, A. Baethmann, K. Einhäupl

      Pages 39-42

   6. Experimental Model in the Cat for Cerebral Sino-Venous Occlusion

      • S. Kannuki, J. Cervos-Navarro, K. Matsumoto, Y. Nakagawa

      Pages 43-52

   7. Brain Function, Pathophysiology and Heparin Therapy in Experimental Cerebral Sinus Vein Thrombosis

      • K. Frerichs, M. Deckert, O. Kempski, K. Einhäupl, A. Baethmann

      Pages 53-58

3. Mechanisms of Brain Tissue Damage

   1. Front Matter

      Pages 59-59

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   2. Physiology and Pathophysiology of the Cerebro-Venous Circulation

      • Ludwig M. Auer

      Pages 61-74

   3. Cerebral Blood Flow in Patients with Sinus Vein Thrombosis

      • P. Schmiedek, K. Einhäupl, E. Moser, U. Büll, G. Leinsinger, T. Kreisig

      Pages 75-83

   4. Vascular Smooth Muscle Reactivity in Hypoxia

      • J. Grote, G. Siegel

      Pages 85-92

   5. Mechanisms of Ischemic Brain Damage

      • O. Kempski, F. Staub, G.-H. Schneider, M. Zimmer, A. Baethmann

      Pages 93-104

   6. Cellular Mechanisms Involved in Generation of Brain Edema

      • U. Heinemann, J. Sarvey

      Pages 105-122

   7. Eicosanoids, Peptides and Amines and the Cerebral Blood Vessels

      • G. Feuerstein

      Pages 123-140

4. Clinical Aspects of Sinus Vein Thrombosis

   1. Front Matter

      Pages 141-141

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   2. Historical Perspectives on the Pathogenesis of Thrombosis in the Cerebral Veins and Sinuses

      • H. J. M. Barnett

      Pages 143-147

   3. Clinical Spectrum of Sinus Venous Thrombosis

      • K. M. Einhäupl, A. Villringer, R. L. Haberl, W. Pfister, M. Deckert, H. Steinhoff et al.

      Pages 149-155

   4. Aseptic Cerebral Venous Thrombosis

      • M. Jacewicz, F. Plum

      Pages 157-170

   5. Clinical Findings and Differential Diagnosis of Cerebral Vein Thrombosis

      • A. Hartmann, J. Wappenschmidt, L. Solymosi, F. Brassel

      Pages 171-186

Contrary to the neurological manifestations of arterial cerebral blood flow disturbances, respective conditions resulting fram obstruction of the cerebro-venous system are far less well understood. Hence, cerebral sinus vein thrombosis (CSVT) ranks prominently among the group of neglected diseases of the brain. This might be attributable (a) to the diagnostic difficulties of the disorder and (b) to the fact that CSVT is associated with a host of heterogeneous neurological symptoms which often are not specific for the underlying venous flow disorder. Another complicating aspect is that CSVT is a consequence of other diseases as disparate as focal infection, trauma, neoplasia, or a thrombosis disposition caused by oral contraceptive use. Although progress has been made in establishing the correct diagnosis of the syndrome, many problems remain as the discussions contained within this volume vividly demonstrate. The same is true for the present understanding of the pathophysiological basis of the disease, eg, concerning the cerebro-venous circulation, the hemodynamic and neuropathological consequences in particular. Part of these deficits may be attributed to a scarcity of solid experimental data due to the limited availability of animal models. However, relevant experimental models are required for an in-depth analysis of the pathophysiological mechanisms, eg, causing brain tissue damage in relationship with the topographical distribution of the venous flow obstruction and, most importantly, for the testing of specific methods of treatment.

• blood
• brain
• circulation
• diagnosis
• diseases
• distribution
• infection
• sinus
• thrombosis
• tissue
• trauma
• treatment

• Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany

  Karl Einhäupl, Alexander Baethmann

• Institute for Neurosurgical Pathophysiology, Johannes Gutenberg-University, Mainz, Germany

  Oliver Kempski

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