Laboratory Aspects of Infections

1. Front Matter

   Pages i-xiv

   PDF

2. Introductory Comments

   • J. C. Sherris

   Pages 1-6

3. Control of Antibiotic-Sensitivity Testing in Britain

   • R. Blowers, D. F. J. Brown

   Pages 7-12

4. Control of Antibacterial Susceptibility Testing: Standardization and Proficiency Testing in Canada

   • I. B. R. Duncan

   Pages 13-17

5. Antibiotic Sensitivity Testing in Australia and New Zealand

   • S. M. Bell

   Pages 19-31

6. Problems of Standardization of Media

   • H. Neussel

   Pages 33-40

7. Effects of Medium on the Results of Antimicrobial Sensitivity Testing

   • J. Bou Casals

   Pages 41-46

8. Influence of Four Commercial Sensitivity Media on in Vitro Activity of Several Antibiotics

   • G. Th. J. Fabius, R. P. Mouton

   Pages 47-54

9. A Spot Plate Method for Antibiotic-Bacterial Killing Rates

   • S. H. Zinner, R. B. Provonchee, K. S. Elias

   Pages 55-59

10. Usefulness of Commercially Available Media to MIC-Determinations of Trimethoprim

    • B. van Klingeren, A. Rutgers

    Pages 61-65

11. Thymidine and the Assessment of Co-Trimoxazole Action in Liquid Media

    • R. Then

    Pages 67-70

12. Antibacterial Susceptibility Testing of Anaerobes

    • Kunitomo Watanabe, Keiu Ninomiya, Izumi Mochizuki, Toshio Miwa, Hiromu Imamura, Shunro Kobata et al.

    Pages 71-76

13. Sensitivity Testing of Mixed Infections

    • M. Taufer, J. Zangger

    Pages 77-80

14. A Diffusion Disc Susceptibility Test for 5-Fluorocytosine

    • C. Utz, S. Shadomy

    Pages 81-87

15. The Susceptibility of Clostridia from the Antarctic Soil to Antibiotics

    • Toshio Miwa, Izumi Mochizuki, Kunitomo Watanabe, Shunro Kobata, Hiromu Imamura, Keiu Ninomiya et al.

    Pages 89-93

16. Brief Antibiotic Exposure and Effect on Bacterial Growth

    • P. J. McDonald, W. A. Craig, C. M. Kunin

    Pages 95-102

17. Trimethoprim and Rifampicin: In Vitro Activities Separately and in Combination

    • D. W. Kerry, J. M. T. Hamilton-Miller, W. Brumfitt

    Pages 103-106

18. A125I-Based Radioimmunoassay for Serum Gentamicin

    • R. A. A. Watson, E. J. Shaw, C. R. W. Edwards

    Pages 107-110

19. Fluorimetric Assay of Tetracycline Mixtures in Plasma

    • D. Hall

    Pages 111-114

20. Assay of Antibiotics with Agar Diffusion Technique

    • Anna-Stina Malmborg

    Pages 115-124

The International Society of Chemotherapy meets every two years to review progress in chemotherapy of infections and of malignant disease. Each meeting gets larger to encompass the extension of chemotherapy into new areas. In some instances, expansion has been rapid, for example in cephalosporins, pen­ icillins and combination chemotherapy of cancer - in others slow, as in the field of parasitology. New problems of resistance and untoward effects arise; reduction of host toxicity without loss of antitumour activity by new substances occupies wide attention. The improved results with cancer chemotherapy, es­ pecially in leukaemias, are leading to a greater prevalence of severe infection in patients so treated, pharmacokinetics of drugs in normal and diseased subjects is receiving increasing attention along with related problems of bioavailability and interactions between drugs. Meanwhile the attack on some of the major bacterial infections, such as gonorrhoea and tubercu­ losis, which were among the first infections to feel the impact of chemotherapy, still continue to be major world problems and are now under attack with new agents and new methods. From this wide field and the 1,000 papers read at the Congress we have produced Proceedings which reflect the variety and vigour of research in this important field of medicine. It was not possible to include all of the papers presented at the Congress but we have attempted to include most aspects of cur­ rent progress in chemotherapy.

• cancer
• chemotherapy
• kinetics
• pharmacokinetics
• research
• resistance
• toxicity

• The London Hospital Medical College, London, UK

  J. D. Williams

• East Birmingham Hospital, Birmingham, UK

  A. M. Geddes

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