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Chemotactic Cytokines

Biology of the Inflammatory Peptide Supergene Family

  • Book
  • © 1991

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Editors:
  1. J. Westwick

    1. The University of Bath, Avon, UK

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  2. I. J. D. Lindley

    1. Sandoz Research Institute, Vienna, Austria

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  3. S. L. Kunkel

    1. University of Michigan, Ann Arbor, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 305)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Granulocyte and Monocyte Chemotactic Factors: Stimuli and Producer Cells

    • Jo Van Damme
    Pages 1-9

  3. Activation of Human Neutrophils by NAP-1 and Other Chemotactic Agonists

    • Marco Baggiolini, Beatrice Dewald, Alfred Walz
    Pages 11-21

  4. Induction and Regulation of Interleukin-8 Gene Expression

    • Robert M. Strieter, Theodore Standiford, Stephen W. Chensue, Keita Kasahara, Steven L. Kunkel
    Pages 23-30

  5. Regulation of Human Interleukin 8 Gene Expression and Binding of Several Other Members of the Intercrine Family to Receptors for Interleukin-8

    • Naofumi Mukaida, Atsushi Hishinuma, Claus O. C. Zachariae, Joost J. Oppenheim, Kouji Matsushima
    Pages 31-38

  6. Formation and Biological Properties of Neutrophil Activating Peptide 2 (NAP-2)

    • Alfred Walz, Roland Zwahlen, Marco Baggiolini
    Pages 39-46

  7. Human Monocyte Chemoattractant Protein-1 (MCP-1)

    • Teizo Yoshimura, Edward J. Leonard
    Pages 47-56

  8. Biological Aspects of Monocyte Chemoattractant Protein-1 (MCP-1)

    • Edward J. Leonard, Alison Skeel, Teizo Yoshimura
    Pages 57-64

  9. Stimulus Specific Induction of Monocyte Chemotactic Protein-1 (MCP-1) Gene Expression

    • Steven L. Kunkel, Theodore Standiford, Keita Kasahara, Robert M. Strieter
    Pages 65-71

  10. GRO: A Novel Chemotactic Cytokine

    • Ruth Sager, Stephen Haskill, Anthony Anisowicz, Douglas Trask, Marilyn C. Pike
    Pages 73-77

  11. PDGF and the Small Inducible Gene (SIG) Family: Roles in the Inflammatory Response

    • Rodney S. Kawahara, Zheng-Wen Deng, Thomas F. Deuel
    Pages 79-87

  12. Human Neutrophil Granule Cationic Protein CAP37 is a Specific Macrophage Chemotaxin that Shares Homology with Inflammatory Proteinases

    • John G. Morgan, H. Anne Pereira, Teresa Sukiennicki, John K. Spitznagel, James W. Larrick
    Pages 89-96

  13. Biochemical and Biological Characterization of NAP-1/ IL-8-Related Cytokines in Lesional Psoriatic Scale

    • Jens-M. Schröder
    Pages 97-107

  14. Chemotactic Cytokines in Inflammatory Skin Disease

    • Richard Camp, Kevin Bacon, Nicholas Fincham, Kay Mistry, Janet Ross, Frances Lawlor et al.
    Pages 109-118

  15. Interleukin-8 —A Mediator of Inflammatory Lung Disease?

    • Diana Smith, Lisa Burrows, John Westwick
    Pages 119-126

  16. Some Aspects of NAP-1 Pathophysiology: Lung Damage Caused by a Blood-Borne Cytokine

    • Antal Rot
    Pages 127-135

  17. Human Mesangial Cell-Derived Interleukin 8 and Interleukin 6: Modulation by an Interleukin 1 Receptor Antagonist

    • Zarin Brown, Lynette Fairbanks, Robert M. Strieter, Guy H. Neild, Steven L. Kunkel, John Westwick
    Pages 137-145

  18. NAP-1/IL-8 in Rheumatoid Arthritis

    • Ivan J. D. Lindley, Miroslav Ceska, Peter Peichl
    Pages 147-156

  19. Abstracts

    • J. G. Morgan, H. A. Pereira, T. Sukiennicki, J. K. Spitznagel, J. W. Larrick, D. R. Forsdyke et al.
    Pages 157-179

  20. Back Matter

    Pages 181-186
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Keywords

About this book

The existence of a new family of chemotactic cytokines was realised in 1987 following the isolation and structural determination by several groups of a peptide consisting of 72 amino acids which was a potent activator of neutrophils and a chemotactic agent for lymphocytes. The first symposium of this series was held at the Royal College of Surgeons of England in December 1988, entitled Novel Neutrophil Stimulating Peptides, and brought together the majority of the laboratories which had published in this area, see Immunology Today 10: 146-147(1989). Since the first symposium there has been a dramatic increase in our knowledge of the biology of this family of structurally related peptides. The Second International Symposium on Chemotactic Cytokines was held at the Royal College of Surgeons of England in June 1990. The aim of this symposium was to provide both a forum for discussion and to determine whether this knowledge can be utilised in the design of novel therapeutic strategies for the treatment of inflammatory disorders. Although the majority of studies have been concerned with the regulation of these peptides at the molecular and cellular level, there is now evidence to suggest that specific members of this superfamily have a role in the pathogenesis of a number of diverse diseases including arthritis, psoriasis, atherosclerosis, wound repair, inflammatory lung diseases and glomerulonephritis.

Editors and Affiliations

  • The University of Bath, Avon, UK

    J. Westwick

  • Sandoz Research Institute, Vienna, Austria

    I. J. D. Lindley

  • University of Michigan, Ann Arbor, USA

    S. L. Kunkel

Bibliographic Information

  • Book Title: Chemotactic Cytokines

  • Book Subtitle: Biology of the Inflammatory Peptide Supergene Family

  • Editors: J. Westwick, I. J. D. Lindley, S. L. Kunkel

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-6009-4

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4684-6011-7Published: 06 April 2012

  • eBook ISBN: 978-1-4684-6009-4Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 180

  • Topics: Immunology, Pharmacology/Toxicology, Biochemistry, general

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