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  • Book
  • © 1991

Biological Reactive Intermediates IV

Molecular and Cellular Effects and Their Impact on Human Health

Editors:

  1. Charlotte M. Witmer

    1. Rutgers University, Piscataway, USA

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  2. Robert R. Snyder

    1. Rutgers University, Piscataway, USA

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  3. David J. Jollow

    1. Medical University of South Carolina, Charleston, USA

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  4. George F. Kalf

    1. Thomas Jefferson University, Philadelphia, USA

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  5. James J. Kocsis

    1. Thomas Jefferson University, Philadelphia, USA

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  6. I. Glenn Sipes

    1. University of Arizona, Tucson, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 283)

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Table of contents (122 chapters)

  1. Front Matter

    Pages i-xvii
    PDF

  2. Sessions I – VI

    1. Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates

      • F. Peter Guengerich, Tsutomu Shimada, Arnaud Bondon, Timothy L. Macdonald
      Pages 1-11

    3. Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites

      • Franz Oesch, Ingolf Gath, Takashi Igarashi, Hansruedi Glatt, Barbara Oesch-Bartlomowicz, Helmut Thomas
      Pages 25-39

    8. Physiological and Toxicological Roles of Hydroperoxides

      • V. Ullrich, M. Schatz, F. Meisch
      Pages 79-86

    10. S-Thiolation of Protein Sulfhydryls

      • James A. Thomas, Eun-Mi Park, Yuh-Cherng Chai, Robert Brooks, Kazuhito Rokutan, Richard B. Johnston Jr.
      Pages 95-103

    11. Cytochrome P-450 as a Target of Biological Reactive Intermediates

      • James R. Halpert, Jeffrey C. Stevens
      Pages 105-109

    12. Hapten Carrier Conjugates Associated with Halothane Hepatitis

      • Lance R. Pohl, David Thomassen, Neil R. Pumford, Lynn E. Butler, Hiroko Satoh, Victor J. Ferrans et al.
      Pages 111-120

    18. Monitoring Human Exposure to Environmental Carcinogens

      • Regina M. Santella, Yu Jing Zhang, Tie Lan Young, Byung Mu Lee, Xiao Qing Lu
      Pages 165-181
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About this book

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co­ chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co­ chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.
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Keywords

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Editors and Affiliations

  • Rutgers University, Piscataway, USA

    Charlotte M. Witmer, Robert R. Snyder

  • Medical University of South Carolina, Charleston, USA

    David J. Jollow

  • Thomas Jefferson University, Philadelphia, USA

    George F. Kalf, James J. Kocsis

  • University of Arizona, Tucson, USA

    I. Glenn Sipes

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Bibliographic Information

  • Book Title: Biological Reactive Intermediates IV

  • Book Subtitle: Molecular and Cellular Effects and Their Impact on Human Health

  • Editors: Charlotte M. Witmer, Robert R. Snyder, David J. Jollow, George F. Kalf, James J. Kocsis, I. Glenn Sipes

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5877-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4684-5879-4Published: 08 July 2012

  • eBook ISBN: 978-1-4684-5877-0Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 912

  • Number of Illustrations: 87 b/w illustrations

  • Topics: Oncology, Pharmacology/Toxicology, Biochemistry, general

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Buy it now

eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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