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Phospholipase A2

Role and Function in Inflammation

  • Book
  • © 1990

Overview

Editors:
  1. Patrick Y-K Wong

    1. New York Medical College, Valhalla, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Edward A. Dennis

    1. University of California at San Diego, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 275)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-viii
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  2. Phospholipase A2 Characterization and Role

    1. Macrophage Phospholipase A2 Activity and Eicosanoid Production: Studies with Phospholipase A2 Inhibitors in P388D1 Cells

      • Keith B. Glaser, Mark D. Lister, Richard J. Ulevitch, Edward A. Dennis
      Pages 1-16

    2. Localization and Evolution of Two Human Phospholipase A2 Genes and Two Related Genetic Elements

      • Lorin K. Johnson, Susan Frank, Peter Vades, Waldemar Pruzanski, Aldons J. Lusis, Jeffrey J. Seilhamer
      Pages 17-34

    3. Structure and Properties of a Secretable Phospholipase A2 from Human Platelets

      • Ruth M. Kramer, Berit Johansen, Catherine Hession, R. Blake Pepinsky
      Pages 35-53

    4. Purification and Characterization of a Phospholipase A2 from Human Osteoarthritic Synovial Fluid

      • Thomas P. Parks, Susan Lukas, Ann F. Hoffman
      Pages 55-81

  3. Phospholipase A2 Function

    1. Phospholipase A2 Activation is the Pivotal Step in the Effector Pathway of Inflammation

      • Peter Vadas, Waldemar Pruzanski
      Pages 83-101

    2. Mobilization and Function of Extracellular Phospholipase A2 in Inflammation

      • Jerrold Weiss, Grace Wright
      Pages 103-113

    3. G-Proteins and Phospholipase Activation in Endothelial Cells

      • Mary E. Gerritsen, Robert J. Mannix
      Pages 115-124

    4. The Role of Phospholipase A2 Activating Protein (PLAP) in Regulating Prostanoid Production in Smooth Muscle and Endothelial Cells Following Leukotriene D4 Treatment

      • Mike A. Clark, John S. Bomalaski, Theresa M. Conway, Mike Cook, Janice Dispoto, Seymore Mong et al.
      Pages 125-144

  4. Disease Models for Inflammation

    1. Cellular and Extracellular Phospholipase A2 Activity in Zymosan Pleurisy in Rat

      • D. W. Morgan, C. Anderson, K. Meyers, J. Coffey, K. Moody, A. Welton
      Pages 145-154

    2. Extracellular Phospholipase A2 Activity in Two in Vivo Models of Inflammation

      • Kathleen R. Gans, Susan R. Lundy, Randine L. Dowling, William M. Mackin, Theresa M. Stevens, Janet S. Kerr
      Pages 155-167

    3. Pharmacological Control of Phospholipase A2 Activity In Vitro and In Vivo

      • Lisa A. Marshall, Joseph Y. Chang
      Pages 169-182

    4. Phospholipase A2 as Leukotriene B4 Secretagogue for Human Polymorphonuclear Leukocytes

      • Bing K. Lam, Chin-Yuh Yang, Patrick Y-K Wong
      Pages 183-191

  5. Back Matter

    Pages 193-199
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Keywords

About this book

This volume in the Advances in Experimental Medicine and Biology Series is dedicated to developing an overall view of the "state-of­ the-art" of knowledge in the field of phospholipase A2 and to exploring the role and function of this enzyme in various inflammatory diseases. This book grew out of two major symposia on phospholipase A2 held in 1989: I). "Phospholipase A2: Pathophysiological Role of Soluble and Membrane-Bound Enzymes" organized by Dr. Doug Morgan and Dr. Ann Welton of Hoffmann-La Roche and sponsored by the New York Academy of Sciences (January 24, 1989). II). "Release and Function of Phospholipase A2 from Inflammatory Cells" organized by Dr. Patrick Wong and Dr. Edward Dennis at the FASEB meeting in New Orleans (March 22, 1989). Readers will find exciting advances in our understanding of the structure, function and molecular biology of phospholipase A2 research which is presented in this volume. The elucidation of gene structures of phospholipase A2 should lead to new insights and new approches in the control and regulation of the enzyme activity. This is primary to better understanding the function of phospholipase A2 and the determination of its activity in cellular and animal systems. Of great importance is the development of animal models for inflammatory disease in order to evaluate the role of phospholipase A2 and its inhibitors. We are convinced that this volume will be an excellent reference that surveys this field in which numerous investigators are currently actively at work.

Editors and Affiliations

  • New York Medical College, Valhalla, USA

    Patrick Y-K Wong

  • University of California at San Diego, La Jolla, USA

    Edward A. Dennis

Bibliographic Information

  • Book Title: Phospholipase A2

  • Book Subtitle: Role and Function in Inflammation

  • Editors: Patrick Y-K Wong, Edward A. Dennis

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5805-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1990

  • Softcover ISBN: 978-1-4684-5807-7Published: 22 March 2012

  • eBook ISBN: 978-1-4684-5805-3Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 210

  • Number of Illustrations: 22 b/w illustrations

  • Topics: Biochemistry, general, Membrane Biology

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