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Neurobiology of Central D1-Dopamine Receptors

  • Book
  • © 1986

Overview

Editors:
  1. George R. Breese

    1. University of North Carolina at Chapel Hill, Chapel Hill, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Ian Creese

    1. University of California, San Diego, La Jolla, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 204)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Benzazepines: Structure-Activity Relationships Between D1 Receptor Blockade and Selected Pharmacological Effects

    • Louis C. Iorio, Allen Barnett, William Billard, Elijah H. Gold
    Pages 1-14

  3. Characterization of Dopamine D-1 and D-2 Receptors

    • John Hyttel, Jørn Arnt
    Pages 15-28

  4. Biochemical and Behavioral Studies of D1 Dopamine Receptors Utilizing SCH 23390

    • Ellen J. Hess, Ian Creese
    Pages 29-52

  5. The Multiplicity of the D1 Dopamine Receptor

    • Richard B. Mailman, David W. Schulz, Clinton D. Kilts, Mark H. Lewis, Hans Rollema, Steven Wyrick
    Pages 53-72

  6. The Dopamine D1 Receptor: Biochemical and Behavioral Aspects

    • Peter H. Andersen, Erik B. Nielsen
    Pages 73-91

  7. Quantitative Autoradiographic Localization of Central Dopamine D-1 and D-2 Receptors

    • Ted M. Dawson, Donald R. Gehlert, James K. Wamsley
    Pages 93-118

  8. Dopamine D1-Receptor Binding in the Living Human Brain

    • Göran Sedvall, Lars Farde, Sharon Stone-Elander, Christer Halldin
    Pages 119-124

  9. Enantiomeric Analogues of SCH 23390 as New Probes for Behavioral Interactions between D1 and D2 Dopaminergic Function

    • John L. Waddington, Anthony G. Molloy, Kathy M. O’Boyle, Marcellina Mashurano
    Pages 125-136

  10. Functional Interactive Effects of D1 and D2 Dopamine Receptor Blockade

    • A. I. Salama, C. F. Saller
    Pages 137-150

  11. Interaction of D1 and D2 Dopamine Receptors in the Expression of Dopamine Agonist Induced Behaviors

    • Allen R. Braun, Paolo Barone, Thomas N. Chase
    Pages 151-166

  12. Electrophysiological Assessment of Dopamine Receptor Subtypes

    • T. Celeste Napier, George R. Breese
    Pages 167-188

  13. The Pathophysiological Functions Mediated by D1 Dopamine Receptors

    • Menek Goldstein, Shigeki Kuga, Yoji Shimizu, Emanuel Meller
    Pages 189-195

  14. Neurobiology of D1 Dopamine Receptors after Neonatal-6-OHDA Treatment: Relevance to Lesch-Nyhan Disease

    • George R. Breese, Robert A. Mueller, T. Celeste Napier, Gary E. Duncan
    Pages 197-215

  15. Back Matter

    Pages 217-219
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Keywords

About this book

Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.

Editors and Affiliations

  • University of North Carolina at Chapel Hill, Chapel Hill, USA

    George R. Breese

  • University of California, San Diego, La Jolla, USA

    Ian Creese

Bibliographic Information

  • Book Title: Neurobiology of Central D1-Dopamine Receptors

  • Editors: George R. Breese, Ian Creese

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5191-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1986

  • Softcover ISBN: 978-1-4684-5193-1Published: 27 December 2012

  • eBook ISBN: 978-1-4684-5191-7Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 219

  • Number of Illustrations: 33 b/w illustrations, 1 illustrations in colour

  • Topics: Psychiatry

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