Genetics, Development, and Evolution

1. Front Matter

   Pages i-xii

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2. Evolution and Morphogenesis: The Regulator Hypothesis

   • Gerald M. Edelman

   Pages 1-27

3. Gene Action and Morphogenesis in Plants

   • G. Ledyard Stebbins

   Pages 29-46

4. Mobile Elements in Maize: A Force in Evolutionary and Plant Breeding Processes

   • Peter A. Peterson

   Pages 47-78

5. Mutation, Apical Meristems and Developmental Selection in Plants

   • Edward J. Klekowski Jr., Hans Mohr, Nina Kazarinova-Fukshansky

   Pages 79-113

6. Properties of Mutable Alleles Recovered from Mutator Stocks of Zea Mays L.

   • Virginia Walbot, Catherine P. Briggs, Vicki Chandler

   Pages 115-142

7. Plant DNA Variation and Stress

   • C. A. Cullis

   Pages 143-155

8. Conditio Sine Qua Non for de Novo Emergence of New Genes and the Concept of Primordial Building Blocks

   • Susumu Ohno, Nozomu Mori, Takeshi Matsunaga

   Pages 157-174

9. Organization of Mutant Genes in Mouse t-Haplotypes

   • Dorothea Bennett

   Pages 175-185

10. Genetic Analysis of Morphogenesis

    • Antonio Garcia-Bellido

    Pages 187-209

11. Cell Lineage and Cell Interactions in the Determination of Developmental Cell Fates

    • Marty Shankland, Gunther S. Stent

    Pages 211-233

12. Structure and Regulated Transcription of DIRS-1, A Novel Dictyostelium Discoideum Transposable Element

    • Joe Cappello, Stephen M. Cohen, Karl Handelsman, Harvey F. Lodish

    Pages 235-251

13. Developmental Constraints and Evolutionary Saltations: A Discussion and Critique

    • Jeffrey S. Levinton

    Pages 253-288

14. Intraspecies Genomic Variation

    • Roy J. Britten

    Pages 289-306

15. Structure and Function of the Human Retroviruses

    • Lee Ratner, Robert C. Gallo

    Pages 307-342

16. The T-DNA Genes of Agrobacterium Plasmids Appear to be of a Complex Evolutionary Origin

    • Jeff Schell

    Pages 343-353

17. Back Matter

    Pages 355-361

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One outstanding question in biology is the problem of devel­ opment: how the genetic instructions encoded in the DNA become expressed in the morphological, physiological, and behavioral features of multicellular organisms, through an ordered sequence of events that extend from the first cell division of the zygote to the adult stage and eventual death. The problem is how a one­ dimensional array of instructions is transformed into a four­ dimensional entity, the organism that exists in space and time. Understanding this transformation is, nevertheless, necessary for mastering the process of evolution. One hundred and twenty-five years after The Origin of Species, we have gained some understanding of evolution at the genetic level. Genetic information is stored in the linear sequence of nucleotides in the DNA. Gene mutations, chromosomal reorganiza­ tions, and a host of related processes introduce variation in the sequence and the amount of DNA. The fate of these variations is determined by interactions within the genome and with the outside environment that are largely understood. We have recently gained a glimpse of how the genome of eukaryotes is organized and will learn much more about it in the future, now that we have the research tools for it.

• DNA
• cell division
• chromosome
• genes
• genetics

• University of Missouri, Columbia, USA

  J. Perry Gustafson

• University of California, Davis, Davis, USA

  G. Ledyard Stebbins, Francisco J. Ayala

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