Host Defenses to Intracellular Pathogens

1. Front Matter

   Pages i-xv

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2. Introduction and Historical Perspective

   1. Introduction and Historical Perspective

      • Toby K. Eisenstein

      Pages 1-4

3. Microbicidal Mechanisms of Leukocytes in Host Defenses

   1. Oxygen Independent Microbicidal Mechanisms of Human Polymorphonuclear Leukocytes

      • John K. Spitznagel, Noburu Okamura

      Pages 5-17

   2. Oxidative Metabolism of Leukocytes and Its Relationship to Bactericidal Activity

      • Lawrence R. DeChatelet, Pamela S. Shirley, Linda C. McPhail

      Pages 19-30

   3. Some Paradoxes of Macrophage Function

      • Mayer B. Goren

      Pages 31-50

   4. Genetic Disorders of Granulocyte Function: What they Tell Us about Normal Mechanisms

      • Richard K. Root

      Pages 51-59

4. The Immune System and Phagocytic Cell Function

   1. Modulation of Effector Lymphokines

      • Stanley Cohen, Tohru Baba, Matsunobu Suko, Helen D’Silva, Takeshi Yoshida

      Pages 61-68

   2. Stimulation of Host Resistance to Metastatic Tumors by Macrophage Activating Agents Encapsulated in Liposomes

      • Richard Kirsh, George Poste

      Pages 69-75

   3. Effect of Prostaglandins on the Production of Interleukin-2

      • R. S. Rappaport, G. R. Dodge

      Pages 77-82

   4. Interaction of Mycobacteria with Normal and Immunologically Activated Alveolar Macrophages

      • Quentin N. Myrvik, Eva S. Leake, Klara Tenner-Racz

      Pages 83-98

   5. Guinea Pig Alveolar Macrophages Probably Kill M. Tuberculosis H37Rv and H37Ra In Vivo by Producing Hydrogen Peroxide

      • P. S. Jackett, P. W. Andrew, V. R. Aber, D. B. Lowrie

      Pages 99-104

   6. Interferon and Host Defense Systems

      • Howard M. Johnson

      Pages 105-119

   7. Mediator Interactions Regulating Macrophage Secretion of Interleukin 1 and Interferon

      • Robert N. Moore, Patricia S. Steeg, Stephan E. Mergenhagen

      Pages 121-126

   8. Macrophage Oxygen-Dependent Killing of Intracellular Parasites: Toxoplasma and Leishmania

      • Henry W. Murray

      Pages 127-143

   9. Immunologic Lesions During Toxoplasma Gondii Infection

      • Edmond A. Goidl, Urban Ramstedt, Thomas C. Jones

      Pages 145-150

   10. Immunodepression in BALB/c Mice Infected with Leishmania Tropica

       • Phillip A. Scott, Jay P. Farrell

       Pages 151-155

5. Host Defenses to Intracellular Bacteria

   1. Cellular Mechanisms of Anti-Mycobacterial Immunity

      • Frank M. Collins

      Pages 157-182

   2. Host Response to Infection with Mycobacterium Bovis (BCG) in Mice: Genetic Study of Natural Resistance

      • Philippe Gros, Emil Skamene, Adrien Forget, Ben Taylor

      Pages 183-188

   3. Cell Mediated Lysis of Lymphocytes Expressing Bacterial Antigens

      • J. A. Hank, P. M. Sondel

      Pages 189-195

   4. Improvement of Abnormal Lymphocyte Responses in “Atypical” Mycobacteriosis with Indomethacin

      • U. G. Mason III, L. E. Greenberg, S. S. Yen, C. H. Kirkpatrick

      Pages 197-201

The subject matter of this volume was the basis for a confer­ ence held in Philadelphia in June, 1981, and is an important one in the contemporary area of how the host interacts with micro­ organisms. In conception, it grew out of a graduate course entitled, "The Infectious Process," which has been taught in the Department of Microbiology and Immunology at Temple University School of Medicine during the past twelve years. This course has explored the broad areas of mechanisms of microbial pathogenesis and host resistance by in-depth consideration of selected models of experimental infection and immunity, as well as the clinical literature. It is noteworthy that there is no adequate text for this material, as the subject matter naturally crosses a wide spectrum of traditional disciplinary lines, encompassing topics as diverse as the mechanisms of action of bacterial toxins, the role of complement and antibody in phagocytosis, and the importance of cross-reacting bacterial polysaccharide antigens in vaccine development. A major portion of the course has always considered "cellular immunity" as it applies to host defenses to intracellular pathogens. It is in this area that the necessity for amalgamation of information from different disciplines is most evident, for one must be intimately concerned with the interactions between the microbe and the phagocyte, both before and after specific immune recognition.

• BCG
• Cell Mediated Lysis
• Cellular Processing
• Interferon
• Lymphocytes Expressing Bacterial Antigens
• Mechanisms Distinct
• Salmonella typhimurium
• Vivo
• cell surface determinants
• cellular immunity
• defense mechanism
• escherichia coli
• mediator interactions
• ocular disease
• polymorphonuclear leukocytes

• Temple University School of Medicine, Philadelphia, USA

  Toby K. Eisenstein

• Smith, Kline, and French Laboratories, Philadelphia, USA

  Paul Actor

• College of Medicine, University of South Florida, Tampa, USA

  Herman Friedman

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