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Immunobiology of Proteins and Peptides—II

  • Book
  • © 1982

Overview

Editors:
  1. M. Z. Atassi

    1. Mayo Clinic, Rochester, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 150)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-viii
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  2. Molecular Aspects of T- and B-Cell Recognition of Protein Antigens

    1. Front Matter

      Pages 1-1
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    2. Autoimmunity to Myelin Basic Protein

      • Robert H. Swanborg, James H. Holda, Joyce A. Killen
      Pages 3-22

    3. The Use of Hybridoma Antibodies to Probe the Antigenic Determinants of Thyroglobulin

      • N. R. Rose, M. Accavitti, E. F. Pydyn, M. A. Leon, R. K. Brown
      Pages 23-35

    4. The Major B and T Cell Determinant on Pigeon Cytochrome c in B10.A Mice

      • Charles Hannum, Michiel Ultee, Louis A. Matis, Ronald H. Schwartz, E. Margoliash
      Pages 37-51

    5. Helper T Cells Specific for Protein Antigens: Role of Self Major Histocompatibility Complex and Immunoglobulin Gene Products

      • Charles A. Janeway Jr., Kim Bottomly, Barry Jones, Patricia P. Jones, Ethan A. Lerner, Louis A. Matis et al.
      Pages 53-71

    6. Dissection of the Molecular Parameters for T-Cell Recognition of a Myoglobin Antigenic Site

      • Colin R. Young, M. Zouhair Atassi
      Pages 73-93

  3. Genetic Control of the Immune Response to Proteins and Peptides

    1. Front Matter

      Pages 95-95
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    2. Genetic Control and Intersite Influences on the Immune Response to Sperm Whale Myoglobin

      • Chella S. David, M. Zouhair Atassi
      Pages 97-125

    3. Genetic Control of the Immune Response to Hemoglobin and its Subunits

      • Christopher J. Krco, A. Latif Kazim, M. Zouhair Atassi, Chella S. David
      Pages 127-140

    4. Immune Response Gene Control of T Dependent Reactivity to Collagen in Man

      • Alan M. Solinger, John D. Stobo
      Pages 141-155

  4. Regulation of the Immune Response

    1. Front Matter

      Pages 157-157
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    2. Myoglobin-Reactive T Cell Clones

      • A. J. Infante, M. Z. Atassi, C. G. Fathman
      Pages 159-167

    3. Use of T Cell Hybridomas in the Analysis of Helper T Cell Functions in B Cell Responses

      • Neal Roehm, John Kappler, Philippa Marrack
      Pages 169-182

    4. Regulation of Growth and Differentiation in B Cell Clones and Hybrids

      • David W. Scott, P. S. Pillai, Scott J. Anderson, Ronald B. Corley
      Pages 183-200

    5. Immunological Studies with Tobacco Mosaic Virus Protein: Differential Activation of B Cell Subpopulations

      • Donna M. Rennick, Philip R. Morrow, Eli Benjamini
      Pages 201-218

    6. Antigen Bridging in the Interaction of T Helper Cells and B Cells

      • Joel W. Goodman, Danute E. Nitecki, Sherman Fong, Zehra Kaymakcalan
      Pages 219-225

  5. Back Matter

    Pages 227-230
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Keywords

About this book

The immune response is largely dependent on molecular inter­ actions involving proteins. The recognition of antigen molecules, whether they are proteins or non-proteins, whether they are self or non-self, takes place at the molecular-cellular interface through membrane receptor molecules that are proteins. The initial step of recognition activates a complex series of cellular events requiring some mechanism of cell-cell interactions and communi­ cations, eventually leading to antibody production. This biolo­ gical cascade is controlled at several positions along its con­ secutive pathways by protein molecules, either in the free form or as receptors on membranes of cells committed to this activity. Clearly, then, the proper understanding of the response by cells of the immune system will depend, to a great measure, on the definition of the molecular events involving protein interactions. Obviously, cells work via molecules and molecules work via cells and, at this level of functional resolution, molecular immunology and cellular immunology will merge and will depend heavily on protein chemistry.

Editors and Affiliations

  • Mayo Clinic, Rochester, USA

    M. Z. Atassi

Bibliographic Information

  • Book Title: Immunobiology of Proteins and Peptides—II

  • Editors: M. Z. Atassi

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-4331-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1982

  • Softcover ISBN: 978-1-4684-4333-2Published: 12 December 2012

  • eBook ISBN: 978-1-4684-4331-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: VIII, 230

  • Topics: Immunology

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