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Temporal Aspects of Therapeutics

  • Book
  • © 1973

Overview

Editors:
  1. John Urquhart

    1. ALZA Corporation, Palo Alto, USA

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  2. F. Eugene Yates

    1. ALZA Corporation, Palo Alto, USA
      Department of Biomedical Enngineering, University of Southern Californis, Los Angeles, USA

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Part of the book series: Alza Conference Series (ALZA)

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-x
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  2. Introduction

    1. Introduction

      • John Urquhart, F. Eugene Yates
      Pages 1-1

  3. Temporal Organization in Biosystems

    1. Front Matter

      Pages 3-3
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    2. The Biological Time Scale

      • Harold J. Morowitz
      Pages 5-15

    3. Temporal and Hierarchical Organization in Biosystems

      • F. E. Yates, A. S. Iberall
      Pages 17-34

    4. Time and Timelessness in Biological Clocks

      • Arthur T. Winfree
      Pages 35-57

  4. Temporal Aspects of Subcellular Synthesis

    1. Front Matter

      Pages 59-59
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    2. Sequential Assembly of Virus Particles

      • Dale Kaiser
      Pages 61-70

    3. Temporal Aspects of Macromolecular Synthesis in Eukaryotic Cells

      • E. Brad Thompson
      Pages 71-91

  5. Temporal Aspects of Organ System Function

    1. Front Matter

      Pages 93-93
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    2. Hormonal Control of the Menstrual Cycle and Ovulation in the Rhesus Monkey

      • E. Knobil
      Pages 95-103

  6. Temporal Patterns and Therapeutics

    1. Front Matter

      Pages 105-105
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    2. Pharmacokinetic Aspects of Controlled Drug Delivery Systems

      • Gerhard Levy
      Pages 107-127

    3. Cell Proliferation Characteristics and Cancer Chemotherapy

      • Seymour Perry
      Pages 129-141

    4. Chronopharmacology in the Treatment of Hypertension with Diuretics

      • Walter J. Meyer III, Catherine S. Delea, Frederic C. Bartter
      Pages 143-163

    5. Testosterone Polydimethylsiloxane Implants and Contraception in Male Rabbits

      • L. L. Ewing, C. Desjardins, L. G. Stratton
      Pages 165-180

    6. Progress Towards an Implantable Glucose Sensor and an Artificial Beta Cell

      • J. S. Soeldner, K. W. Chang, S. Aisenberg, John M. Hiebert
      Pages 181-207

    7. Epilogue

      • John Urquhart, F. Eugene Yates
      Pages 209-210

  7. Back Matter

    Pages 211-213
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Keywords

About this book

Drugs are molecular agents of a physician's purpose. Discussions of their mechanisms of action center upon biochemical processes, even though the therapeutic intent may be to create an effect at a higher level of organization. We often prescribe to stop pain, increase vigor, assure sleep, curtail infection, alleviate inflammation, elevate mood, etc. To achieve rational therapy at high levels of organization it is not enough to know the molecular structures of drugs, and the points at which they couple into biochemical reaction chains. Such knowledge deals with static concepts, whereas the biosystems we treat extend in the dimensions of time as well as in those of space. Even when "resting", a biosystem manifests a dynamic stability, and sustains numerous processes whose successive states follow trajectories in time. A chemical message is not necessarily received by a biosystem as the same signal at one time as at another. Studies of cell cycle biochemistry, and of circadian variations in toxicity of some agents, have emphasized the importance of time as an aspect of therapeutics. In this volume, temporal aspects of living systems are considered. In the first section they are dealt with from the point of view of general design principles, in three papers by Morowitz, by Yates and Iberall, and by Winfree. In the second section, papers by Kaiser and by Thompson present accounts of sequential events in fundamental subcellular processes.

Editors and Affiliations

  • ALZA Corporation, Palo Alto, USA

    John Urquhart, F. Eugene Yates

  • Department of Biomedical Enngineering, University of Southern Californis, Los Angeles, USA

    F. Eugene Yates

Bibliographic Information

  • Book Title: Temporal Aspects of Therapeutics

  • Editors: John Urquhart, F. Eugene Yates

  • Series Title: Alza Conference Series

  • DOI: https://doi.org/10.1007/978-1-4684-2847-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1973

  • Softcover ISBN: 978-1-4684-2849-0Published: 19 April 2012

  • eBook ISBN: 978-1-4684-2847-6Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: X, 214

  • Topics: Science, Humanities and Social Sciences, multidisciplinary

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