Principles of Applied Clinical Chemistry Chemical Background and Medical Applications

1. Front Matter

   Pages i-xvii

   PDF

2. Introduction

   1. Introduction

      • Samuel Natelson, Ethan A. Natelson

      Pages 1-3

3. Body Fluids and Electrolytes

   1. Front Matter

      Pages 5-5

      PDF

   2. Maintenance of the Steady State in the Human

      • Samuel Natelson, Ethan A. Natelson

      Pages 7-12

   3. Acids and Bases

      • Samuel Natelson, Ethan A. Natelson

      Pages 13-29

   4. Partial Pressures (\({p_{{O_2}}}\) and \({p_{C{O_2}}}\))

      • Samuel Natelson, Ethan A. Natelson

      Pages 31-66

   5. Maintenance of Constant pH in the Human

      • Samuel Natelson, Ethan A. Natelson

      Pages 67-91

   6. Maintenance of Constant Osmotic Pressure in Body Fluids

      • Samuel Natelson, Ethan A. Natelson

      Pages 93-108

   7. Maintenance of Constant Ion Concentration in Body Fluids: Sodium, Potassium, and Chloride

      • Samuel Natelson, Ethan A. Natelson

      Pages 109-139

   8. Maintenance of Constant Ion Concentration in Body Fluids: Calcium, Magnesium, Phosphate, and Sulfate

      • Samuel Natelson, Ethan A. Natelson

      Pages 141-194

   9. Mechanisms for Maintenance of a Steady State Between Plasma and Interstitial Fluid

      • Samuel Natelson, Ethan A. Natelson

      Pages 195-211

   10. Abnormal Blood pH (Acidosis and Alkalosis)

       • Samuel Natelson, Ethan A. Natelson

       Pages 213-246

   11. Fluid and Electrolyte Applications

       • Samuel Natelson, Ethan A. Natelson

       Pages 247-282

4. The Kidney and Sweat Glands in Fluid and Electrolyte Balance

   1. Front Matter

      Pages 283-283

      PDF

   2. The Kidney

      • Samuel Natelson, Ethan A. Natelson

      Pages 285-355

   3. The Sweat Glands

      • Samuel Natelson, Ethan A. Natelson

      Pages 357-369

5. Back Matter

   Pages 371-393

   PDF

"Clinical Chemistry encompasses the study of the fundamental princi­ ples of chemistry as applied to an understanding of the functioning of the human organism in health and disease." 1 From its very definition, clinical chemistry is an applied science. Its scope includes the following: I. Studies designed to elucidate the chemical mechanisms whereby the human normally functions. 2. The application of this information to an understanding of the disease process in the human. 3. The development of methodology and instrumentation in order to facilitate data gathering so as to apply the above principles to the diagnosis and treatment of disease in the human. This book is an attempt to organize the information gathered relative to points I and 2 into a logical sequence so as to define the areas oj learning encompassed by the science oj clinical chemistry. It is constructed around the subject which is the target of this science, namely the human. The material is presented from the point of view of the clinical chemist, but since it is impossible to discuss a mechanism adequately without visualizing its parts, some schematic anatomical drawings are included to simplify the discussion of responses to chemical challenges. The book is partly a curriculum which has been worked out by the authors for the training of clinical chemists and clinical pathologists. It should also be useful for the training of medical technologists.

• Calcitonin
• Hormone
• Parathormon
• Vitamin D
• clinical chemistry
• drugs
• health
• information
• science

• Department of Biochemistry, Michael Reese Hospital and Medical Center, Chicago, USA

  Samuel Natelson

• Baylor College of Medicine Methodist Hospital, Houston, USA

  Ethan A. Natelson

Policies and ethics