Molecular-Genetic Mechanisms of Development

1. Front Matter

   Pages i-xiv

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2. The Elementary Acts of Morphogenesis: Processes of Biosynthesis of Informational Macromolecules. The Biochemical Mechanisms of Transfer of Genetic Information

   • Zhores A. Medvedev

   Pages 1-22

3. Molecular-Genetic Mechanisms of Reproduction and Morphogenesis of Viruses

   • Zhores A. Medvedev

   Pages 23-78

4. Molecular-Genetic Mechanisms of Morphogenesis and Intracellular Biochemical Differentiation of Monochromosomal Bacterial Cells

   • Zhores A. Medvedev

   Pages 79-125

5. Molecular-Genetic Systems Controlling Morphogenesis and Differentiation in Multicellular Organisms. Molecular Structure of Chromosomes of the Cell Nucleus and Structural and Biochemical Features of Genetic and Functional Differentiation of Chromosomes

   • Zhores A. Medvedev

   Pages 127-182

6. Biochemical Realization of the Morphogenetic Program. Changes in Proteins and Nucleic Acids During Processes of Differentiation and Development

   • Zhores A. Medvedev

   Pages 183-258

7. Chromosomal Proteins and Their Role in Regulation of Selective Gene Activity during Differentiation and in Specialized Cells

   • Zhores A. Medvedev

   Pages 259-293

8. Induction of Differentiated Activity of the Genes by Cytoplasmic and Chromosomal Factors and Its Role in the General Organization of Morphogenesis

   • Zhores A. Medvedev

   Pages 295-341

9. Molecular Mechanisms Programming Morphogenesis and Differentiation. A Theoretical Analysis

   • Zhores A. Medvedev

   Pages 343-390

10. Recent Advances in the Study of Molecular-Genetic Mechanisms of Development

    • Zhores A. Medvedev

    Pages 391-410

11. Back Matter

    Pages 411-418

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Although as part of my general plan, this book is a continua­ tion of my earlier monograph "Protein Biosynthesis and Problems of Ontogenesis,"* published in 1963, in all other respects it is an independent work. The earlier monograph was devoted to the analysis of many of the aspects of the problem of protein biosynthesis, and problems of inheritance and development were discussed only insofar as they are derivatives of the problems of biosynthesis. The complex act of protein biosynthesis, comprising autore­ production of the genetic material (DNA), formation of the templates of protein synthesis (messenger RNA), synthesis of amino acid carriers (transfer RNA), formation of ribosomes and polysomes, activation of amino acids, and so on, was examined in the previous monograph not merely from the standpoint of interaction between the components of this system, but also from that of their mani­ festation in actual biological systems during morphogenesis and aging of the organism. However, both morphogenesis and aging were investigated very generally, Simply as models, without any detailed analysis of their specific features and complexity. The present book is therefore a logical continuation of its prede­ cessor. It rests largely on a comprehensive analysis of the molecular-genetic and biochemical aspects of development and differentiation of living organisms, and questions of protein biosyn­ thesis are discussed briefly and generally, and only so far as is necessary for fulfillment of the primary task. • Zh. A. Medvedev. 1966. Protein Biosynthesis and Problems of Heredity. Developement.

• DNA
• RNA
• Termination
• biosynthesis
• cell nucleus
• development
• genes
• genetics
• immunology
• metabolism
• morphogenesis
• protein
• tissue
• transcription
• translation

• Laboratory of Molecular Radiobiology, Institute of Medical Radiology, Obninsk, USSR

  Zhores A. Medvedev

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