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Mechanisms in Fibre Carcinogenesis

  • Book
  • © 1991

Overview

Editors:
  1. Robert C. Brown

    1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

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  2. John A. Hoskins

    1. Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Neil F. Johnson

    1. Inhalation Toxicology Research Institute, Albuquerque, USA

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Part of the book series: NATO Science Series A: (NSSA, volume 223)

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Table of contents (49 chapters)

  1. Front Matter

    Pages i-xiii
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  2. The Carcinogenicity of Mineral Fibres

    1. Front Matter

      Pages 1-1
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    3. Animal studies

      1. Mesotheliomas in Man and Experimental Animals
        • J. C. Wagner
        Pages 45-49
      2. Experimental Studies on Mineral Fibre Carcinogenesis: An Overview
        • J. M. G. Davis
        Pages 51-58
      3. The Relevance of Animal Bioassays to Assess Human Health Hazards to Inorganic Fibrous Materials
        • Neil F. Johnson
        Pages 59-69
      4. Relative Intrinsic Potency of Asbestos and Erionite Fibers: Proposed Mechanism of Action
        • David L. Coffin, Andrew J. Ghio
        Pages 71-80
      5. Histopathological Analysis of Tumour Types after Intraperitoneal Injection of Mineral Fibres in Rats
        • S. Rittinghausen, H. Ernst, H. Muhle, R. Fuhst, U. Mohr
        Pages 81-89
      6. Radiation-Induced Mesotheliomas in Rats
        • F. F. Hahn, P. J. Haley, A. F. Hubbs, M. D. Hoover, D. L. Lundgren
        Pages 91-99

  3. Chemical and Physical Properties

    1. Front Matter

      Pages 101-101
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    2. Fibre Size and Chemistry

      1. Carcinogenic Effect Related to the Fiber Physics and Chemistry
        • K. R. Spurny
        Pages 103-113
      2. Fibre Size and Chemistry Effects <i>in Vitro</i> and <i>in Vivo</i> Compared
        • R. C. Brown, J. A. Hoskins, E. A. Sara, C. E. Evans, K. J. Cole
        Pages 115-120
      3. Inflammation and Immunomodulation Caused by Short and Long Amosite Asbestos Samples
        • K. Donaldson, S. Szymaniec, X. Y. Li, D. M. Brown, G. M. Brown
        Pages 121-130
      4. Fiber Dimensions and Mesothelioma: A Reappraisal of the Stanton Hypothesis
        • Agnes B. Kane
        Pages 131-141
      5. Acute Pulmonary Effects of Inhaled Wollastonite Fibers are Dependent on Fiber Dimensions and Aerosol Concentrations
        • David B. Warheit, Kimberly A. Moore, Michael C. Carakostas, Mark A. Hartsky
        Pages 143-156
      6. Toxicological Aspects of the Pathogenesis of Fiber-Induced Pulmonary Effects
        • G. Oberdörster, B. E. Lehnert
        Pages 157-179
      7. Durability of Various Mineral Fibres in Rat Lungs
        • H. Muhle, B. Bellmann, F. Pott
        Pages 181-187
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About this book

The Editors are sorry that the production of this volume was delayed by the ill­ health of one of them and we hope that this does not detract from the value of the con­ tents. For once this delay is not the fault of any of the authors only the editors are to blame. Many of the workers in the field of fibre toxicology became convinced by the middle 1980's that the worst of the furore over asbestos was over although we were left with an intriguing problem - how does asbestos cause disease? It was expected that the future impact of fibres on human health would be very small since asbestos exposure would be controlled and there was little chance that man-made fibres would prove haz­ ardous. These man-made fibres are much thicker than asbestos and, in most cases, they are less durable in the body. Both of these properties are believed to make them much less likely to cause disease. However many of us had fallen into the habit of calling these materials "asbestos substitutes" and thus they have acquired a little of the notoriety at­ tached to the natural fibrous minerals. Very few of these man-made fibres are actually used as replacements for asbestos. Asbestos was not suitable for the uses to which the insulation wools are usually put and the ceramic fibres are replacements for fire brick not asbestos which is destroyed at the temperatures at which these materials are used.

Editors and Affiliations

  • Medical Research Council Toxicology Unit, Carshalton, Surrey, UK

    Robert C. Brown, John A. Hoskins

  • Inhalation Toxicology Research Institute, Albuquerque, USA

    Neil F. Johnson

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