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Drug Studies in the Elderly

Methodological Concerns

  • Book
  • © 1986

Overview

Editors:
  1. Neal R. Cutler

    1. Department of Geriatrics Cedars-Sinai Medical Center, University of California-Los Angeles School of Medicine, Los Angeles, USA

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  2. Prem K. Narang

    1. Clinical Pharmacokinetics Research Laboratory Pharmacy Department Clinical Center, National Institutes of Health, Bethesda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xxv
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  2. Research Determinants in Aging

    1. Front Matter

      Pages 1-1
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    2. Epidemiology and Demography of Aging

      • Thomas M. Vogt
      Pages 3-27

    3. Age: A Complex Variable

      • Prem K. Narang
      Pages 29-48

    4. Physiological Changes with Aging

      • Alexander M. M. Shepherd
      Pages 49-67

    5. Immunity and Aging

      • William B. Ershler, Marc E. Weksler
      Pages 69-79

    6. Cardiovascular Changes with Aging

      • Brian F. Johnson, Janice C. Hitzhusen
      Pages 81-99

    7. The Effects of Age on Hepatic Drug Metabolism

      • Cho-Ming Loi, Robert E. Vestal
      Pages 101-121

    8. Hematological Effects of Aging

      • Elizabeth J. Read, Harvey G. Klein
      Pages 123-150

    9. The Aging Brain

      • Neal R. Cutler
      Pages 151-164

  3. Pharmacokinetics and Pharmacodynamics in the Elderly

    1. Front Matter

      Pages 165-165
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    2. The Tricyclic Antidepressants

      • Matthew V. Rudorfer, William Z. Potter
      Pages 167-187

    3. Methodological Concerns for Clinical Trials in Geriatrics

      • Darrell R. Abernethy
      Pages 189-205

    4. Effect of Age on the Clinical Pharmacokinetics of Antiarrhythmic Drugs

      • J. W. Massarella, K.-C. Khoo
      Pages 207-247

    5. Beta Blockers in the Elderly

      • David S. Roffman, Alan Forrest
      Pages 249-272

    6. Antiepileptic Drugs in the Elderly

      • William H. Theodore
      Pages 273-282

    7. Pharmacokinetics and Bioavailability of Corticosteroids in the Treatment of Neurological Diseases of the Elderly

      • Marinos C. Dalakas
      Pages 283-298

    8. Pharmacological Treatment of Parkinson’s Disease

      • Donald B. Calne, Arto Laihinen
      Pages 299-311

    9. Cognitive Enhancers in Alzheimer’s Disease

      • Neal R. Cutler, Prem K. Narang
      Pages 313-332

  4. General Perspectives

    1. Front Matter

      Pages 333-333
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Keywords

About this book

Clinical trials are the most definitive tool for evaluation of the applica­ bility of clinical investigations. The main objective of clinical investiga­ tions is to assess the potential value of a therapeutic entity in the treat­ ment or prophylaxis of a disease or a condition. It is also deemed necessary at this stage to obtain information regarding the undesirable side effects, associated risks, and their interrelationship with clinical assessments. Most of these clinical investigations conform, in some form or fashion, to the guidelines adopted by the Food and Drug Administration (FDA) for a given class of compounds. Clinical investigations in the past have not included specific studies in special or subpopulations, e.g., the elderly. Because of an ever-increasing elderly population, newer policies for clinical investigations are now being debated with the recognition of enhanced drug sensitivity in this special population. This key research activity can lead not only to improved health care in the elderly but also to control of its costs.

Editors and Affiliations

  • Department of Geriatrics Cedars-Sinai Medical Center, University of California-Los Angeles School of Medicine, Los Angeles, USA

    Neal R. Cutler

  • Clinical Pharmacokinetics Research Laboratory Pharmacy Department Clinical Center, National Institutes of Health, Bethesda, USA

    Prem K. Narang

Bibliographic Information

  • Book Title: Drug Studies in the Elderly

  • Book Subtitle: Methodological Concerns

  • Editors: Neal R. Cutler, Prem K. Narang

  • DOI: https://doi.org/10.1007/978-1-4684-1253-6

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Publishing Corporation 1986

  • Softcover ISBN: 978-1-4684-1255-0Published: 01 March 2012

  • eBook ISBN: 978-1-4684-1253-6Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XXVI, 464

  • Number of Illustrations: 38 b/w illustrations

  • Topics: Geriatrics/Gerontology, Aging, Pharmacology/Toxicology

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