Skip to main content
SpringerLink
Log in

Heparin

Structure, Function, and Clinical Implications

  • Book
  • © 1975

Overview

Editors:
  1. Ralph A. Bradshaw

    1. Department of Biological Chemistry, Washington University School of Medicine, St. Louis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Stanford Wessler

    1. Department of Medicine, The Jewish Hospital, St. Louis, USA
      Washington University School of Medicine, St. Louis, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 52)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (34 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Structural Aspects

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Molecular Properties

      1. The Chemistry of Heparin
        • Roger W. Jeanloz
        Pages 3-17
      2. Crystalline Structure of Heparin
        • Edward D. T. Atkins, Ian A. Nieduszynski
        Pages 19-37
      3. Three-Dimensional Model of Heparin
        • Leon Yuan, Salvatore S. Stivala
        Pages 39-49

    3. Biosynthesis

      1. Heparin and Heparin-Like Substances of Cells
        • Jeremiah E. Silbert, Hynda K. Kleinman, Cynthia K. Silbert
        Pages 51-60
      2. Biosynthesis of Heparin
        • Gudrun Bäckström, Anund Hallen, Magnus Höök, Leif Jansson, Ulf Lindahl
        Pages 61-77
      3. Metabolism of Macromolecular Heparin in Murine Neoplastic Mast Cells
        • Sören Ögren, Ulf Lindahl
        Pages 79-83
      4. Demonstration of Endogenous Heparin in Rat Blood
        • Alan A. Horner
        Pages 85-93

    5. Analytical and Pharmacological Considerations

      1. What is “Heparin”?
        • Louis B. Jaques
        Pages 139-147
      2. Determination of Heparin in Small Tissue Samples
        • Louis B. Jaques
        Pages 149-154
      3. Identification and Quantification of Tissue Heparin by Microelectrophoresis: A Critique
        • Alan A. Horner
        Pages 155-162
      4. Standards for Heparin
        • Milica Brozovic, D. R. Bangham
        Pages 163-179
      5. Application of the Kinetics of Heparin to the Formulation of Dosage Schedules
        • J. Worth Estes
        Pages 181-192

  3. Functional Aspects

    1. Front Matter

      Pages 193-193
      Download chapter PDF

    2. Effect on Blood Coagulation: Interaction with Antithrombin III

      1. Antithrombin III: A Backward Glance O’Er Travel’d Roads
        • Walter H. Seegers
        Pages 195-215
Back to top

Keywords

About this book

The International Symposium on Heparin, held May 13-15, 1974, in St. Louis, Missouri, as a part of the dedication of the Shoenberg Pavilion of the Jewish Hospital of St. Louis, was conceived as a forum to bring together physicians and scientists with a basic in­ terest in the structure, function and clinical usefulness of heparin. Few naturally occurring substances have commanded the breadth of interest among members of the biomedical research community as this compound has. Aspects of its covalent and three-dimensional struc­ ture, its biosynthesis, its interaction with and effect on physio­ logically important moieties and its use as a therapeutic agent in a variety of disease states have been actively studied for the past several decades. Thus, the present state of these studies seemed to be a timely subject for discussion, not only to gather together in one place representative samples of the myriad of data on heparin but also to underscore the ever increasing necessity for communica­ tion between basic research and clinical practice.

Editors and Affiliations

  • Department of Biological Chemistry, Washington University School of Medicine, St. Louis, USA

    Ralph A. Bradshaw

  • Department of Medicine, The Jewish Hospital, St. Louis, USA

    Stanford Wessler

  • Washington University School of Medicine, St. Louis, USA

    Stanford Wessler

Bibliographic Information

  • Book Title: Heparin

  • Book Subtitle: Structure, Function, and Clinical Implications

  • Editors: Ralph A. Bradshaw, Stanford Wessler

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-0946-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1975

  • Softcover ISBN: 978-1-4684-0948-2Published: 31 August 2012

  • eBook ISBN: 978-1-4684-0946-8Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 423

  • Topics: Cardiology, Hematology

Publish with us

Policies and ethics

Back to top

Search

Navigation