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Neurotransmitter Interactions and Cognitive Function

  • Book
  • © 1992

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Editors:
  1. Edward D. Levin

    1. Department of Psychiatry, Duke University Medical Center, Durham, USA

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  2. Michael W. Decker

    1. Abbott Laboratories, Abbott Park, USA

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  3. Larry L. Butcher

    1. Laboratory of Chemical Neuroanatomy, Department of Psychology, University of California, Los Angeles, USA

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Table of contents (22 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Interactions among Neurotransmitters: Their Importance to the “Integrated Organism”

    • Roger W. Russell
    Pages 1-14

  3. The Cholinergic Basal Forebrain and its Telencephalic Targets: Interrelations and Implications for Cognitive Function

    • Larry L. Butcher
    Pages 15-26

  4. Synaptic Organization of Basal Forebrain Cholinergic Projection Neurons

    • László Záborszky
    Pages 27-65

  5. Functional Pharmacology of Basal Forebrain Dopamine

    • T. Celeste Napier
    Pages 66-77

  6. Cholinergic/Noradrenergic Interactions and Memory

    • Michael W. Decker
    Pages 78-90

  7. The Role of the Noradrenergic System in Higher Cerebral Functions: Experimental Studies about the Effects of Noradrenergic Modulation on Electrophysiology and Behavior

    • Paavo J. Riekkinen, Jouni Sirvio, Paavo Riekkinen Jr., Antti Valjakka, Pekka Jakala, Esa Koivisto et al.
    Pages 91-102

  8. Septal Noradrenergic and Glutamatergic Influences on Hippocampal Cholinergic Activity in Relation to Spatial Learning and Memory in Mice

    • Robert Jaffard, Aline Marighetto, Jacques Micheau
    Pages 103-117

  9. Neurotransmitter Interactions and Responsivity to Cholinomimetic Agents

    • V. Haroutunian, A. C. Santucci, K. L. Davis
    Pages 118-143

  10. The Importance of D1 and D2 Interactions with Nicotinic and Muscarinic Systems for Working Memory Function

    • Edward D. Levin, Jed E. Rose
    Pages 144-158

  11. Neurotransmitter Systems in Hippocampus and Prelimbic Cortex, Dopamine-Acetylcholine Interactions in Hippocampus, and Memory in the Rat

    • Gilberto N. O. Brito
    Pages 159-182

  12. Nicotinic-Muscarinic Interactions in Cognitive Function

    • Edward D. Levin, Roger W. Russell
    Pages 183-195

  13. The Influence of Neurotensin Upon Cholinergic Function

    • Gary L. Wenk
    Pages 196-206

  14. Serotonin Influences on Cholinergic Function: Possible Interactions in Learning and Memory

    • Howard J. Normile, Harvey J. Altman
    Pages 207-227

  15. The Contribution of the Serotonergic Innervation of the Hippocampus to the Effects of Combined Cholinergic/Serotonergic Deficits

    • Gal Richter-Levin, Menahem Segal
    Pages 228-239

  16. Overlapping Neural Substrates Underlying Defense Reactions, Aversive Memory, and Convulsive Behavior

    • Carlos Tomaz, Marcus L. Brandao, Norberto Garcia-Cairasco
    Pages 240-256

  17. Potentiation of the Effects of Antimuscarinic Drugs on Behavior by Serotonin Depletion: Specificity and Relation to Learning and Memory

    • C. H. Vanderwolf, D. Penava
    Pages 257-276

  18. Interactions of Neurotransmitters and Neuroanatomy: It’s Not What You Do, It’s The Place that You Do It

    • David S. Olton, Kevin Pang
    Pages 277-286

  19. Intraseptal GABAergic Infusions Disrupt Memory in the Rat: Method and Mechanisms

    • James J. Chrobak, T. Celeste Napier
    Pages 287-300

  20. Working Memory and Cholinergic Autoregulation in the Medial Septal Area

    • Bennet Givens, David Olton
    Pages 301-311
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Keywords

About this book

JAMES L. MCGAUGH Understanding of the nature and functions of neurotransmitter systems in the brain has increased enormously in recent decades. Lack of knowledge required us, not too long ago, to use the adjective "putative" when discussing transmitters. Such caution is no longer essential (at least for a number of transmitters). Impressive progress has been achieved in understanding the pharmacology, biochemistry and anatomy of transmitter systems. There has, however, been relatively less progress in understanding the functioning of brain transmitters in regulating and mediating behavior. A simple and certainly correct explanation for this is, of course, that understanding of neurotransmitter functions requires prior detailed knowledge of basic pharmacology, biochemistry and anatomy. Beyond that, it now seems likely that progress in understanding the functions of brain neurotransmitters will proceed only as we examine the interactions of neurotransmitter systems in regulating behavioral functions. This premise is, of course, suggested by the findings of studies of the chemical neuroanatomy of the brain: Neurotransmitter systems are influenced by other neurotransmitter systems and, in tum, influence the same as well as other systems. No system works alone. The chapters in this book explicitly examine the interactions of neurotransmitter systems involved in the regulation of cognitive processes. The facts and interpretations offered provide compelling support for the premise that cognitive processes are orchestrated by interactions among neurotransmitter systems. And, they offer promise that understanding of such interactions will be of critical importance in the develop­ ment of treatments for brain diseases affecting cognitive functioning.

Editors and Affiliations

  • Department of Psychiatry, Duke University Medical Center, Durham, USA

    Edward D. Levin

  • Abbott Laboratories, Abbott Park, USA

    Michael W. Decker

  • Laboratory of Chemical Neuroanatomy, Department of Psychology, University of California, Los Angeles, USA

    Larry L. Butcher

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