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  • Conference proceedings
  • © 1972

The Artery and the Process of Arteriosclerosis

Measurement and Modification, The second half of the Proceedings of an Interdisciplinary Conference on Fundamental Data on Reactions of Vascular Tissue in Man, April 19–25, 1970, Lindau, West Germany

Editors:

  1. Stewart Wolf

    1. The University of Texas Medical Branch, University of Texas System, Galveston, USA
      The Marine Biomedical Institute, Galveston, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 16B)

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Table of contents (10 papers)

  1. Front Matter

    Pages i-xvii
    PDF

  2. Measurement and Consequences of Arteriosclerosis

    • Marcel Vastesaeger
    Pages 1-20
    PDF
  3. PDF
  4. PDF

  5. Diet

    • Stewart Wolf
    Pages 93-118
    PDF

  6. Exercise and Smoking

    • Stewart Wolf
    Pages 119-149
    PDF

  7. Psychosocial Forces

    • Stewart Wolf
    Pages 151-169
    PDF

  8. Endocrine and Metabolic Factors

    • Stewart Wolf
    Pages 171-188
    PDF

  9. Drugs

    • Stewart Wolf
    Pages 189-212
    PDF

  10. Sudden Cardiac Death

    • Stewart Wolf
    Pages 213-275
    PDF
  11. PDF

  12. Back Matter

    Pages 283-337
    PDF
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About this book

Substantial progress toward reconciling disparate theories of the pathogenesis of arteriosclerosis was recorded in Volume I of this book. the proceedings of an interdisciplinary workshop conference held at Lindau. Germany, April 19-25, 1970. Strong evidence was ad­ duced that the early stages of arteriosclerosis consist of intimal proliferation similar to that associated with the increase in arteri­ al size and caliber that characterizes normal growth. The findings described recall a theory proposed by Richard Thoma (Thoma and Kaefer, 1889) of Heidelberg toward the end of the nineteenth century. He sug­ gested that the pathogenesis of arteriosclerosis began with intimal thickening that was initially adaptive. Past a certain point, how­ ever, the thickening compromised the nutrition of the artery wall, leading inevitably to degenerative changes. In 1944 Hueper (Hueper, 1944), reemphasized the threat to the nu­ tritional support of the artery and proposed that the many etiologic factors capable of inducing arterial atheroma did so through the final common pathway of interfering with oxidative mechanisms in the vessel wall. Thus, it is proposed that arteriosclerosis is basically an aspect of the "behavior" of the artery. The nature of the lesion, therefore, depends more on the biochemical and structural response capabilities of the tissue itself than on the characteristics of the various etiologic agents. The idea that arteriosclerosis begins as uncontrolled or disturbed adaptive behavior was shared by Duff and also by Winternitz (Duff, 1954; Winternitz, 1954).
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Keywords

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Editors and Affiliations

  • The University of Texas Medical Branch, University of Texas System, Galveston, USA

    Stewart Wolf

  • The Marine Biomedical Institute, Galveston, USA

    Stewart Wolf

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Bibliographic Information

  • Book Title: The Artery and the Process of Arteriosclerosis

  • Book Subtitle: Measurement and Modification, The second half of the Proceedings of an Interdisciplinary Conference on Fundamental Data on Reactions of Vascular Tissue in Man, April 19–25, 1970, Lindau, West Germany

  • Editors: Stewart Wolf

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4615-8225-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1972

  • Softcover ISBN: 978-1-4615-8227-4Published: 25 November 2012

  • eBook ISBN: 978-1-4615-8225-0Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XVII, 337

  • Number of Illustrations: 30 b/w illustrations

  • Topics: Cardiology, Angiology

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Download book PDF

Buy it now

Softcover Book USD 159.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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