Alzheimer's Disease: Cellular and Molecular Aspects of Amyloid beta

1. Front Matter

   Pages i-xvii

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2. The Contribution of Microscopy to the Study of Alzheimer’s Disease, Amyloid Plaques and Aβ Fibrillogenesis

   • J. Robin Harris

   Pages 1-44

3. Transgenic Mouse Models for APP Processing and Alzheimer’s Disease: Early and Late Defects

   • Tom van Dooren, Ilse Dewachter, Peter Borghgraef, Fred van Leuven

   Pages 45-63

4. Oxidative stress in Alzheimer’s Disease: Implications for Prevention and Therapy

   • Christian Behl

   Pages 65-78

5. β-Secretase, APP and Aβ in Alzheimer’s Disease

   • Robert Vassar

   Pages 79-103

6. The Non-Amyloidogenic Pathway: Structure and Function of α-Secretases

   • Elżbieta Kojro, Falk Fahrenholz

   Pages 105-127

7. Amyloid β Degradation: A Challenging Task for Brain Peptidases

   • Laura Morelli, Ayelén Bulloj, María Celeste Leal, Eduardo M. Castaño

   Pages 129-145

8. The Protective Role of Vitamin E in Vascular Amyloid β-Mediated Damage

   • Francisco José Muñoz, Montserrat Solé, Mireia Coma

   Pages 147-165

9. Amyloid Accumulation and Pathogensis of Alzheimer’s Disease: Significance of Monomeric, Oligomeric and Fibrillar Aβ

   • Charles C. Glabe

   Pages 167-177

10. Cholesterol and Amyloid β Fibrillogenesis

    • Katsuhiko Yanagisawa

    Pages 179-202

11. Alzheimer’s β-Amyloid: Insights into Fibril Formation and Structure from Congo Red Binding

    • Hideyo Inouye, Daniel A. Kirschner

    Pages 203-224

12. The Aluminium-Amyloid Cascade Hypothesis and Alzheimer’s Disease

    • Christopher Exley

    Pages 225-234

13. Amyloid-β Metal Interaction and Metal Chelation

    • Math P. Cuajungco, Christopher J. Frederickson, Ashley I. Bush

    Pages 235-254

14. The Interaction of Amyloid-β with ApoE

    • Donald B. Carter

    Pages 255-272

15. Clusterin and Alzheimer’s Disease

    • Miguel Calero, Agueda Rostagno, Blas Frangione, Jorge Ghiso

    Pages 273-298

16. Acetylcholinesterase Interaction with Alzheimer Amyloid β

    • Nibaldo C. Inestrosa, Juan Paulo Sagal, Marcela Colombres

    Pages 299-317

17. Membrane Disordering Effects of β-Amyloid Peptides

    • Gunter P. Eckert, W. G. Wood, W. E. Müller

    Pages 319-337

18. The Role of Alzheimer Aβ Peptides in Ion Transport Across Cell Membranes

    • Vernon M. Ingram

    Pages 339-349

19. Amyloid Inhibitors and β-Sheet Breakers

    • Claudio Soto, Lisbell Estrada

    Pages 351-364

20. Cholesterol and Alzheimer’s Disease: Statins, Cholesterol Depletion in APP Processing and Aβ Generation

    • Tobias Hartman

    Pages 365-380

To understand Alzheimer's disease (AD) is one of the major thrusts of present-day clinical research, strongly supported by more fimdamental cellular, biochemical, immunological and structural studies. It is these latter that receive attention within this book. This compilation of 20 chapters indicates the diversity of work currently in progress and summarizes the current state of knowledge. Experienced authors who are scientifically active in their fields of study have been selected as contributors to this book, in an attempt to present a reasonably complete survey of the field. Inevitably, some exciting topics for one reason or another have not been included, for which we can only apologize. Standardization of terminology is often a problem in science, not least in the Alzheimer field; editorial effort has been made to achieve standardization between the Chapters, but some minor yet acceptable personal / author variation is still present, i. e. P-amyloid/amyloid-P; Ap42/Apl-42/APi. 42! The book commences with a broad survey of the contribution that the range of available microscopical techniques has made to the study of Alzheimer's amyloid plaques and amyloid fibrillogenesis. This chapter also serves as an Introduction to the book, since several of the topics introduced here are expanded upon in later chapters. Also, it is significant to the presence of this chapter that the initial discovery of brain plaques, by Alois Alzheimer, utilized light microscopy, a technique that continues to be extremely valuable in present-day AD research.

• Alzheimer
• Calcium
• attention
• biochemistry
• enzymes
• proteins

• Institute of Zoology, University of Mainz, Mainz, Germany

  J. Robin Harris

• Institute of Biochemistry, University of Mainz, Mainz, Germany

  Falk Fahrenholz

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