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Gadd45 Stress Sensor Genes

  • Book
  • © 2013

Overview

Editors:
  1. Dan A. Liebermann

    1. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, USA

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  2. Barbara Hoffman

    1. Professor of Biochemistry, Temple University School of Medicine, Philadelphia, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Provides a comprehensive picture of the unique global role Gadd45 genes play as stress sensors and the molecular pathways involved
  • The functions of Gadd45 proteins are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation
  • Gadd45 proteins are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 793)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-x
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  2. Gadd45 in Stress Signaling, Cell Cycle Control, and Apoptosis

    • Jesús M. Salvador, Joshua D. Brown-Clay, Albert J. Fornace Jr.
    Pages 1-19

  3. Gadd45 in Modulation of Solid Tumors and Leukemia

    • Barbara Hoffman, Dan A. Liebermann
    Pages 21-33

  4. Gadd45 Proteins: Key Players of Repair-Mediated DNA Demethylation

    • Andrea Schäfer
    Pages 35-50

  5. Gadd45 Proteins in Immunity

    • Ingo Schmitz
    Pages 51-68

  6. Gadd45 in the Liver: Signal Transduction and Transcriptional Mechanisms

    • Jianmin Tian, Joseph Locker
    Pages 69-80

  7. The Role of the Gadd45 Family in the Nervous System: A Focus on Neurodevelopment, Neuronal Injury, and Cognitive Neuroepigenetics

    • Faraz A. Sultan, J. David Sweatt
    Pages 81-119

  8. Gadd45 Stress Sensors in Preeclampsia

    • Ossie Geifman-Holtzman, Yali Xiong, Eliezer J. Holtzman
    Pages 121-129

  9. Back Matter

    Pages 131-134
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Keywords

About this book

Emerging evidence indicates that the Gadd45 family of genes play a unique and critical role as sensors of stress, including genotoxic, physiological and oncogenic stress.   The stress response Gadd45 family of genes (Gadd45a, Gadd45b & Gadd45g), discovered by Dr. Liebermann and other researchers, encode for small (18 kd) nuclear/cytoplasmic proteins).  These genes are rapidly induced by a wide variety of endogenous and exogenous stress stimuli. In spite of marked similarities, Gadd45 genes are regulated differently & exhibit functional diversity.  Gadd45 are implicated in cell cycle arrest, DNA demethylation & repair, apoptosis, cell survival, genomic stability, inflammation, & in response to physiological and oncogenic stress.   Functions of Gadd45 genes are mediated by protein-protein interactions that modulate structure/function of other cellular proteins implicated in cell cycle regulation and the response of cells to stress; these interactions vary depending upon the biological setting including cell type, developmental stage and stress/stimulus.  Protein partners include cdc2/cyclinB1, p21, the p38/JNK stress induced kinase pathways, and PCNA/histones. The purpose of this book is to provide a comprehensive picture of the unique global role Gadd45 genes play as stress sensors & the molecular pathways involved.  

Editors and Affiliations

  • Professor of Biochemistry, Temple University School of Medicine, Philadelphia, USA

    Dan A. Liebermann, Barbara Hoffman

Bibliographic Information

  • Book Title: Gadd45 Stress Sensor Genes

  • Editors: Dan A. Liebermann, Barbara Hoffman

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4614-8289-5

  • Publisher: Springer New York, NY

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 2013

  • Softcover ISBN: 978-1-4939-5390-5Published: 23 August 2016

  • eBook ISBN: 978-1-4614-8289-5Published: 08 October 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 134

  • Number of Illustrations: 7 b/w illustrations, 11 illustrations in colour

  • Topics: Gene Function, Biochemistry, general, Human Genetics

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