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Molecular Pathology of Hematolymphoid Diseases

  • Book
  • © 2010

Overview

Editors:
  1. Cherie H. Dunphy

    1. Dept. Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, USA

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  • Integrated with a medical perspective
  • Divided according to neoplastic and non-neoplastic disease
  • Each chapter focuses on a specific disease entity
  • Quick and user-friendly reference
  • Includes supplementary material: sn.pub/extras

Part of the book series: Molecular Pathology Library (MPLB, volume 4)

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Table of contents (45 chapters)

  1. Front Matter

    Pages i-xv
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  2. Molecular Pathology of Hematolymphoid Neoplasms: General Principles

    1. Front Matter

      Pages 1-1
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    2. Molecular Oncogenesis

      • Aniruddha J. Deshpande, Christian Buske, Leticia Quintanilla-Martinez, Falko Fend
      Pages 3-19

    3. Genetic Predispositions for Hematologic and Lymphoid Disorders

      • Frederick G. Behm
      Pages 21-64

    4. Prognostic Markers

      • David Bahler
      Pages 65-72

    5. Cancer Stem Cells: Potential Targets for Molecular Medicine

      • Isabel G. Newton, Catriona H. M. Jamieson
      Pages 73-80

    6. Gene Therapy for Leukemia and Lymphoma

      • Xiaopei Huang, Yiping Yang
      Pages 81-89

    7. Chemical and Environmental Agents (Including Chemotherapeutic Agents and Immunosuppression)

      • Richard J. Q. McNally
      Pages 91-106

    8. Viral Oncogenesis

      • Alexander A. Benders, Margaret L. Gulley
      Pages 107-116

  3. Specific Techniques and Their Applications in Molecular Hematopathology

    1. Front Matter

      Pages 118-118
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    2. Techniques to Determine Clonality in Hematolymphoid Malignancies

      • Daniel E. Sabath
      Pages 119-128

    3. Techniques to Detect Defining Chromosomal Translocations/Abnormalities

      • Jennifer J. D. Morrissette, Karen Weck, Cherie H. Dunphy
      Pages 129-152

    4. Molecular Techniques to Detect Disease and Response to Therapy: Minimal Residual Disease

      • Marie E. Beckner, Jeffrey A. Kant
      Pages 153-164

    5. Detection of Resistance to Therapy in Hematolymphoid Neoplasms

      • Karen Weck
      Pages 165-171

    6. Monitoring Engraftment of Bone Marrow Transplant by DNA Fingerprinting

      • Jessica K. Booker
      Pages 173-176

    7. Gene Expression Profiling

      • Cherie H. Dunphy
      Pages 177-189

    8. Proteomics of Human Malignant Lymphoma

      • Megan S. Lim, Rodney R. Miles, Kojo S. J. Elenitoba-Johnson
      Pages 191-202

    9. Mouse Models of Hematolymphoid Malignancies

      • Krista M. D. La Perle, Suzana S. Couto
      Pages 203-208

  4. Molecular Pathology of Hematolymphoid Neoplasms: Specific Subtypes

    1. Front Matter

      Pages 210-210
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    2. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

      • Patricia Aoun
      Pages 211-220
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Keywords

About this book

The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.

Editors and Affiliations

  • Dept. Pathology & Laboratory Medicine, University of North Carolina, Chapel Hill, USA

    Cherie H. Dunphy

Bibliographic Information

  • Book Title: Molecular Pathology of Hematolymphoid Diseases

  • Editors: Cherie H. Dunphy

  • Series Title: Molecular Pathology Library

  • DOI: https://doi.org/10.1007/978-1-4419-5698-9

  • Publisher: Springer New York, NY

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag New York 2010

  • Hardcover ISBN: 978-1-4419-5697-2Published: 27 April 2010

  • Softcover ISBN: 978-1-4614-2590-8Published: 27 May 2012

  • eBook ISBN: 978-1-4419-5698-9Published: 16 June 2010

  • Series ISSN: 1935-987X

  • Series E-ISSN: 1935-9888

  • Edition Number: 1

  • Number of Pages: XIX, 620

  • Number of Illustrations: 29 b/w illustrations, 93 illustrations in colour

  • Topics: Pathology

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