Glycoprotein Hormones

1. Front Matter

   Pages i-xx

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2. Reflections Past and Present

   1. Front Matter

      Pages 1-1

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   2. Reflections on Purifying Gonadotropins in the 1960s

      • Harold Papkoff

      Pages 3-7

   3. Where to from Here?

      • Robert J. Ryan

      Pages 8-10

   4. Remembrance of Things Foregone

      • Darrell N. Ward

      Pages 11-15

3. Regulation of Gene Expression

   1. Front Matter

      Pages 17-17

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   2. Endocrine Regulation of Glycoprotein Hormone Alpha Subunit Gene Expression in Transgenic Mice

      • C. M. Clay, R. A. Keri, D. L. Hamernik, L. L. Heckert, J. H. Nilson

      Pages 19-35

   3. Coordinate Regulation of the Gonadotropin Subunit Genes in Pituitary and Placenta

      • Pamela L. Mellon, David J. Steger, Friedemann Horn, Kerry M. Barnhart, Marita Büscher, Claudia Stauber et al.

      Pages 36-43

   4. Role of Helix-Loop-Helix Proteins in Gonadotropin Gene Expression

      • Stephen M. Jackson, Kerry M. Barnhart, Pamela L. Mellon, Arthur Gutierrez-Hartmann, James P. Hoeffler

      Pages 44-64

   5. Cyclic AMP-Mediated Hormonal Regulation of Gene Transcription

      • Joel F. Habener, Terry E. Meyer

      Pages 65-74

   6. Regulation and Expression of Thyroid Stimulating Hormone

      • Bruce D. Weintraub, Myung K. Kim, Donald L. Bodenner, N. Rao Thotakura, Mariusz W. Szkudlinski, Lata Joshi et al.

      Pages 75-78

4. Hormonal Protein Structure/Function

   1. Front Matter

      Pages 79-79

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   2. Human Chorionic Gonadotropin: Progress in Determining Its Tertiary Structure

      • Joyce W. Lustbader, Chuan Wang, Xiaolu Zhang, Steven Birken, Hao Wu, Jonathan Miles Brown et al.

      Pages 81-102

   3. Receptor Binding Regions of hLH and hCGβ-Subunit: Structural and Functional Properties

      • Henry T. Keutmann

      Pages 103-117

   4. Evidence for Altered Splicing in Two Members of the Chorionic Gonadotropin β Gene Cluster

      • Masaki Bo, Brian L. Strauss, Irving Boime

      Pages 118-121

   5. Delineation of Subunit and Receptor Contact Sites by Site-Directed Mutagenesis of hCGβ

      • David Puett, Jianing Huang, Haiying Xia

      Pages 122-134

5. Protein Processing and Posttranslational Events

   1. Front Matter

      Pages 135-135

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   2. Folding of the β-Subunit of hCG and Its Role in Assembly of the α-β Heterodimer

      • Raymond W. Ruddon, Jeffrey R. Huth, Elliott Bedows, Kimberly Mountjoy, Fulvio Perini

      Pages 137-155

   3. Structure and Function of the Gonadotropin Free α Molecule of Pregnancy

      • Diana L. Blithe

      Pages 156-166

   4. Glycosylation and Glycoprotein Hormone Function

      • Jacques U. Baenziger

      Pages 167-174

Advances in the field of glycoprotein hormones necessitated a second international symposium on this topic, held March 11 to 14, 1993, in Santa Barbara, California, and again sponsored by Serono Symposia, USA. The meeting was twofold in its concept: (1) the dissemination of the current research in the field and (2) honoring three scientists who have greatly contributed to this field, Drs. Harold Papkoff, Robert Ryan, and Darrell Ward, upon their retirements. We were honored to have Dr. John Pierre present as a participant at the meeting and also serving as master of ceremonies at the banquet. Certainly one of the highlights at the first meeting, held in 1989, was the cloning of the CG/LH receptor. This second meeting was also filled with insightful and innovative scientific presentations. Significant advances in the regulation of gene transcription of the gonadotropins were presented by Pamela Mellon, James Hoeffler, John Nilson, Bruce Weintraub, and Joel Habener. These presentations reflected major advances from the in the understanding concepts offered at the last meeting. Other advances of hormone structure/function included the continuing work by Joyce Lustbader on the determination of the three-dimensional structure of hCG, including a new approach using nonisotopic labels for 3-D and 4-D NMR imaging. New insights into biosynthesis of hCG were proposed by Irving Boime. Studies directed at identifying receptor contact regions were presented by Henry Keutmann and David Puett.

• Expression
• Protein
• Regulation
• Translation
• gene expression
• metabolism
• tertiary structure
• transcription

• Irving Center for Clinical Research Columbia University College of Physicians and Surgeons, New York, USA

  Joyce W. Lustbader

• Department of Biochemistry, University of Georgia, Athens, USA

  David Puett

• Eppley Institute for Research, University of Nebraska Medical Center, Omaha, USA

  Raymond W. Ruddon

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