Purines and Myocardial Protection

1. Front Matter

   Pages i-xxiii

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2. Purine Metabolism in the Heart

   1. Front Matter

      Pages 1-1

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   2. Physiologic and Pathophysiologic Significance of Purine Metabolism in the Heart

      • Anwar-Saad A. Abd-Elfattah, Jian-Hua Guo, El-Mostafa El-Guessab, Andrew S. Wechsler

      Pages 3-16

   3. Purine Metabolism in the Ischemic Canine and Human Immature Myocardium Deficient of 5’-Nucleotidase

      • Anwar S. Abd-Elfattah, David R. Salter, Andrew S. Wechsler

      Pages 17-37

   4. Cardiac Adenosine Metabolism: Physiological Implications

      • Andreas Deussen

      Pages 39-53

   5. Purine Metabolism in Human Cardiomyocytes and Endothelium — Implications for Protection of the Heart During Cardiac Surgery

      • Ryszard T. Smolenski, Magdi H. Yacoub

      Pages 55-80

   6. Assessment of Interstitial Fluid Adenosine: Implications for Exogenous and Endogenous Adenosine-Mediated Cardioprotection

      • David G. L. Van Wylen

      Pages 81-94

   7. Adenosine and Coronary Vascular Pharmacology

      • Worku Abebe, Ravi B. Marala, S. Jamal Mustafa

      Pages 95-104

   8. Alterations in Energy Substrate Metabolism During Oxidative Stress

      • Alexander S. Clanachan, Gary D. Lopaschuk

      Pages 105-116

3. Myocardial Protection with Purines

   1. Front Matter

      Pages 117-117

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   2. Purines and Myocardial Protection: An Overview

      • Anwar-Saad A. Abd-Elfattah, Jian-Hua Guo, El-Mostafa El-Guessab, Shin-Ping Gao, Yang Gu

      Pages 119-148

   3. Myocardial Protection with Endogenous Purines

      1. Nucleoside Transport Protein: Properties and Regulation

         • Anwar S. A. Abd-Elfattah, Samir Mardini, Jian-Hua Guo, Mohanad I. Shehab, Nashaat El-Singaby, Shin-Ping Gao et al.

         Pages 151-163

      2. Role of Nucleoside Transport in Myocardial Injury and Protection: Separation Between Ischemic and Reperfusion Injury Using a Selective Nucleoside Transport Blocker, <span class="u-monospace">p</span>-Nitrobenzylthioinosine, NBMPR

         • Anwar S. A. Abd-Elfattah, Jian-Hua Guo, Mohanad I. Shehab, Nashaat R. El-Singaby, Andrew S. Wechsler

         Pages 165-181

      3. Myocardial Protection Using Nucleoside Transport Inhibitors

         • Herman Van Belle

         Pages 183-195

      4. Selective Blockade of Nucleoside Transport by NBMPR Attenuates Reperfusion-Mediated Ventricular Arrhythmias

         • Anwar-Saad A. Abd-Elfattah, Scott A. Hanan, C. Mac Dyke, Francis Lee, Hamdy M. Aly, Andrew S. Wechsler

         Pages 197-208

      5. Nucleoside Transport in the Human Myocardium

         • Jeff Hoehner, Andrew S. Wechsler, Anwar-Saad A. Abd-Elfattah

         Pages 209-218

      6. Selective Nucleoside Transport Blocker NBMPR Attenuates Myocardial Stunning in a Rabbit Model Deficient of Xanthine Oxidase

         • Anwar S. Abd-Elfattah, Ricky P. Maddox, Michael E. Jessen, Ivan M. Rebeyka, Andrew S. Wechsler

         Pages 219-230

      7. Amplification of Endogenous Adenosine by “Adenosine Regulating Agents” as a Therapeutic Approach to the Treatment of Cardiac Ischemic Syndromes

         • Kevin Mullane, Manuel Galiñanes, David J. Hearse

         Pages 231-258

   4. Myocardial Protection with Exogenous Purines

      1. Organ Protection with ATP-Magnesium Chloride

         • James M. Harkema, Irshad H. Chaudry

         Pages 261-284

      2. Adenosine and Adenosine Receptor Protection of the Ischemic Heart

         • Robert D. Lasley, Robert J. Mentzer Jr.

         Pages 285-295

A critical review of the most up-to-date research on purines and myocardial protection. The role of purines in reversible `myocardial stunning' and irreversible (myocardial infarction) ischemic injury, ventricular arrhythmias, and ischemic preconditioning is discussed in detail, by experts. All reviews address recent and rather controversial issues on purines and myocardial protection. Mechanisms of cardioprotection of exogenous versus endogenous purines are discussed in detail. The contribution of internationally recognized experts in the field of purines and cardiovascular physiology and in myocardial protection makes this a unique and interesting book for clinicians, basic scientists and students.

• arrhythmia
• cardiovascular
• heart
• myocardial infarction
• physiology
• platelet

• Cardiothoracic Division, Department of Surgery, Richmond, USA

  Anwar-Saad A. Abd-Elfattah

• Department of Surgery, Medical College of Virginia, Richmond, USA

  Andrew S. Wechsler

Policies and ethics