Etiology of Hodgkin’s Disease

1. Front Matter

   Pages i-x

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2. Epidemiology: Overview and Spatial Clustering

   • Freda E. Alexander

   Pages 1-13

3. Evidence of an Increased Frequency of HLA-DPB1*0301 in Hodgkin’s Disease Supports an Infectious Aetiology

   • G. Malcolm Taylor, David A. Gokhale, Derek Crowther, Penella Woll, Freda Alexander, Ruth F. Jarrett

   Pages 15-25

4. What Can we Learn About the Aetiology of Hodgkin’s Disease from Family Studies?

   • Paul H. Levine, Albert Lin, Margaret A. Tucker

   Pages 27-31

5. Epstein-Barr Virus and Lymphomas: An Overview

   • Lawrence S. Young, Gerald Niedobitek

   Pages 33-51

6. Hodgkin’s Disease and Epstein-Barr Virus

   • Ruth F. Jarrett

   Pages 53-63

7. Relationship Between Expression of Cellular Genes and Epstein-Barr Virus in Hodgkin’s Disease

   • Mehdi N. Jiwa, Joost J. Oudejans, Adriaan JC van den Brule, Paul van der Valk, Jau MM. Walboomers, Chris J. L. M. Meijer

   Pages 65-73

8. The Epidemiology of EBV-Associated Hodgkin’s Disease

   • Ruth F. Jarrett, Alison A. Armstrong

   Pages 75-87

9. Hodgkin’s Disease in Human Immunodeficiency Virus Infected Individuals

   • Stephen J. Hamilton-Dutoit

   Pages 89-98

10. Hodgkin’s Disease and Human Herpesvirus-6: A Model for Studies of New Aetiological Agents

    • Paul H. Levine, Mark Manak, Linda Jagodzinski

    Pages 99-107

11. The Reed-Sternberg Cell and the CD30 Antigen

    • Horst. Dürkop, Ute. Latza, Brunangelo. Falini, Gianpaolo. Nadali, Giovanni. Pizzolo, Harald. Stein

    Pages 109-126

12. CD30 Ligand: Cloning, Characterisation and Biological Activities

    • Hans-Jürgen. Gruss, Steven. K. Dower

    Pages 127-141

13. Single Cell PCR at the DNA and RNA Level: A Novel Approach to the Study of Hodgkin’s Disease

    • Lorenz Trümper, Heiner Daus, Judith Roth, Uschi Loftin, Angela Gause, Michael Pfreundschuh

    Pages 143-159

14. The Nature of the Lymphocytes in Hodgkin’s Disease

    • Sibrand Poppema, Lydia Visser

    Pages 161-171

15. Propagation of Hodgkin and Reed-Sternberg Cells

    • Ursula Kapp, Jürgen Wolf, Christof von Kalle, Volker Diehl

    Pages 173-186

16. A SCID Mouse Model of Hodgkin’s Disease? Transplantation of Hodgkin’s and Non-Hodgkin’s Lymphomas Into Severe Combined Immunodeficient Mice

    • Andrew S. Krajewski, Jacqueline. Lowrey, Sarah E. M. Howie, Alice Gallagher, Ruth F. Jarrett

    Pages 187-195

17. The Pathogenesis of Hodgkin’s Disease: Oncogene, Tumour Suppressor Gene, and Epstein-Barr Viral Studies

    • Lawrence M. Weiss

    Pages 197-208

18. Tumour Suppressor Genes in Hodgkin’s Disease

    • Miguel A. Piris, Juan C. Martinez, Margarita Sanchez-Beato, Juan F. Garcia, Carmen Bellas, Javier Menarguez et al.

    Pages 209-222

19. Back Matter

    Pages 223-227

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This volume reports the proceedings of a NATO Advanced Workshop held at Cameron House Hotel, Loch Lomond, Scotland, from May 2 - 5, 1994. The major impetus for this workshop was the realisation, over the past 7 years, that the Epstein-Barr virus is associated with a proportion of cases of Hodgkin's disease and is likely to play an aetiological role. There were four main aims of the workshop: first, to discuss the recent findings in relation to Epstein­ Barr virus and the aetiology of Hodgkin's disease; second, to relate these data to the epidemiology of Hodgkin's disease; third, to discuss other potential aetiological factors and finally, to discuss future directions for research into Hodgkin's disease. Leading experts in the field have contributed chapters to this volume. There is some overlap among chapters, particularly regarding Epstein-Barr virus, thereby allowing different groups to express views on similar topics. Perhaps, however, the most surprising feature of the workshop was the lack of controversy regarding the role of Epstein-Barr virus in Hodgkin's disease, an association that was treated with great scepticism at the beginning of the decade. The first three chapters, by Alexander, Taylor et al., and Levine el al., discuss the epidemiology of Hodgkin's disease with particular attention to clustering and genetic susceptibility. These chapters represent the first attempt to bring together epidemiological and molecular studies in Hodgkin's disease.

• Antigen
• Pathogene
• epidemiological
• epidemiology
• transplantation

• University of Glasgow, Glasgow, Scotland

  Ruth F. Jarrett

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