Glycoimmunology 2

1. Front Matter

   Pages i-ix

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2. Glycobiology: The Basics

   1. Front Matter

      Pages 1-1

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   2. Novel Pathways in Complex-Type Oligosaccharide Synthesis

      • Dirk H. Van den Eijnden, Alex P. Neeleman, Hans Bakker, Irma Van Die

      Pages 3-7

   3. Defective Glycosyltransferases are Not Good for Your Health

      • Harry Schachter, Jenny Tan, Mohan Sarkar, Betty Yip, Shihao Chen, James Dunn et al.

      Pages 9-27

   4. Probing Carbohydrate-Protein Interactions by High-Resolution NMR Spectroscopy

      • S. W. Homans, R. A. Field, M. J. Milton, M. Probert, J. M. Richardson

      Pages 29-38

3. Oligosaccharides and Protein Recognition

   1. Front Matter

      Pages 39-39

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   2. The Structure of a Human Rheumatoid Factor Bound to IgG Fc

      • Brian J. Sutton, Adam L. Corper, Maninder K. Sohi, Roy Jefferis, Dennis Beale, Michael J. Taussig

      Pages 41-50

   3. Carbohydrate Recognition Systems in Innate Immunity

      • Ten Feizi

      Pages 51-54

   4. Biosynthesis of Sulfated L-Selectin Ligands in Human High Endothelial Venules (HEV)

      • Jean-Philippe Girard, François Amalric

      Pages 55-62

   5. Endothelial Sialyl Lewis X as a Crucial Glycan Decoration on L-Selectin Ligands

      • Risto Renkonen

      Pages 63-73

   6. Role of Lectin-Glycoconjugate Recognitions in Cell-Cell Interactions Leading to Tissue Invasion

      • Claudine Kieda

      Pages 75-82

4. Oligosaccharides and Biological Function

   1. Front Matter

      Pages 83-83

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   2. Protein O-GlcNAcylation: Potential Mechanisms for the Regulation of Protein Function

      • Bradley K. Hayes, Gerald W. Hart

      Pages 85-94

   3. A Longitudinal Study of Glycosylation of a Human IgG3 Paraprotein in a Patient with Multiple Myeloma

      • Muhammad Farooq, Noriko Takahashi, Mark Drayson, John Lund, Royston Jefferis

      Pages 95-103

   4. The Role of the Lectin Calnexin in Conformation Independent Binding to N-Linked Glycoproteins and Quality Control

      • John J. M. Bergeron, A. Zapun, W.-J. Ou, R. Hemming, F. Parlati, P. H. Cameron et al.

      Pages 105-116

5. Glycosylation and Inflammation

   1. Front Matter

      Pages 117-117

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   2. Immunodetection of Glycosyltransferases: Prospects and Pitfalls

      • Eric G. Berger, Peter Burger, Lubor Borsig, Martine Malissard, Kristina Mrkoci Felner, Steffen Zeng et al.

      Pages 119-132

   3. Cytokine and Protease Glycosylation as a Regulatory Mechanism in Inflammation and Autoimmunity

      • Philippe Van den Steen, Pauline M. Rudd, Raymond A. Dwek, Jo Van Damme, Ghislain Opdenakker

      Pages 133-143

   4. Occurrence and Possible Function of Inflammation-Induced Expression of Sialyl Lewis-X on Acute-Phase Proteins

      • Willem Van Dijk, Els C. M. Brinkman-Van der Linden, Ellen C. Havenaar

      Pages 145-150

6. Glycosylation and Disease

   1. Front Matter

      Pages 151-151

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The Jenner International Glycoimmunology Meetings have charted the rapid devel­ opment of glycobiology within the field of inflammation. In less than a decade, the science has grown from basically being involved in carbohydrate analysis to the understanding of how sugars are associated with inflammation and how they have potential as anti­ inflammatory therapeutics. The 4th Jenner International Glycoimmunology Meeting was re­ cently held in Loutraki, Greece, and set the scene for what promises to be an exciting future for the speciality. Discussion reflected the rapid advances glycobiology is making and ranged from the basic biochemistry of carbohydrate physiology to therapeutic trials utilizing synthetic sugars designed to block inflammatory responses. The meeting is summarized in considerable detail in this book which will provide the interested scientist and clinician with the essential up-to-date facts within the field of glyco­ immunology. Acknowledgments Many people have been involved in ensuring the success of the Jenner Glycoimmu­ nology Meetings but none more so than my secretary Susan Henderson who has borne the brunt of all four meetings and is currently preparing for the 5th.

• Oligosaccharid
• Polysaccharid
• biochemistry
• development
• infections
• physiology
• proteins
• tissue

"Excellent reviews...the contributors, internationally known for their research in the area of glycobiology, do a great job of outlining the current knowledge...should prove a welcome addition to laboratories."
Doody's Review Service

• St. George’s Hospital Medical School, University of London, London, UK

  John S. Axford

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