Overview
- Editors:
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Marc E. Lippman
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Lombardi Cancer Research Center, USA
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Robert B. Dickson
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Lombardi Cancer Research Center, USA
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Table of contents (20 chapters)
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Oncogenes, Antioncogenes, and Tumor Prognosis
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- Margaret C. Sunderland, William L. McGuire
Pages 3-22
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- Eva Y.-H. P. Lee, Rob Bookstein, Wen-Hwa Lee
Pages 23-44
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Growth Factors and Their Receptors
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- David G. Fernig, John A. Smith, Philip S. Rudland
Pages 47-78
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- Charles W. Daniel, Gary B. Silberstein
Pages 79-92
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- Douglas Yee, Neal Rosen, Roberto E. Favoni, Kevin J. Cullen
Pages 93-106
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- David S. Salomon, Fortunato Ciardiello, Eva M. Valverius, Nancy Kim
Pages 107-157
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- Ronald N. Buick, Jorge Filmus, Jon G. Church
Pages 159-170
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- Carlos Sonnenschein, Ana M. Soto
Pages 171-194
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Estrogen and Antiestrogens
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Front Matter
Pages 195-195
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- K. S. McCarty Jr., K. S. McCarty Sr.
Pages 197-220
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- Y. Iino, D. F. C. Gibson, V. C. Jordan
Pages 221-237
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- Bruce Westley, Felicity E. B. May
Pages 259-271
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- Mary Beth Martin, Miguel Saceda, Ralph K. Lindsey
Pages 273-288
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- Carlos L. Arteaga, C. Kent Osborne
Pages 289-304
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- Elizabeth A. Musgrove, Robert L. Sutherland
Pages 305-331
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Stromal-Epithelial Interactions and Metastases
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Front Matter
Pages 333-333
About this book
In Breast Cancer: Cellular and Molecular Biology [Kluwer Academic Pub lishers, 1988], we tried to present an introduction to the emerging basic studies on steroid receptors, oncogenes, and growth factors in the regulation of normal and malignant mammary epithelium. The response to this volume was superb, indicating a tremendous interest in basic growth regulatory mechanisms governing breast cancer and controlling its malignant progres sion. In the two years since its publication, much new and exciting in formation has been published and the full interplay of regulatory mechanisms is now beginning to emerge. We have divided this book into four sections that we hope will unify important concepts and help to crystallize areas of consensus and/or disagreement among a diverse group of basic and clinical scientists working on the disease. The first section is devoted to studies on oncogenes, antioncogenes, proliferation, and tumor prognosis. The first chapter, by Sunderland and McGuire, introduces the characteristics of breast cancer as studied by patho logists to establish prognostic outcome. Of particular interest is a new proto oncogene called HER-2 (or neu), which is rapidly becoming accepted as a valuable new tumor marker of poor prognosis. The second chapter, by Lee Bookstein and Lee, introduces the best known antioncogene, the retinoblas toma antioncogene, whose expression is sometimes lost in breast cancer. Malignant progression appears to be influenced by the balance of proto oncogene and antioncogene expression.
Reviews
This book is excellent in overall quality. The book is an important and useful addition to the scientific literature. It provides a fresh perspective on breast cancer for students and for clinical and basic researchers alike.Journal of the Nat. Cancer