The Biology and Prevention of Aerodigestive Tract Cancers

1. Front Matter

   Pages i-x

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2. The Etiology and Prevention of Aerodigestive Tract Cancers

   • David Schottenfeld

   Pages 1-19

3. Epidemiology of Vitamin A and Aerodigestive Cancer

   • Curtis J. Mettlin

   Pages 21-26

4. Multiple Primary Squamous Carcinomas of the Upper Aerodigestive Tract

   • Robert M. Byers

   Pages 27-29

5. Genetic and Environmental Interactions as Risks for Aerodigestive Cancers

   • Margaret R. Spitz, T. C. Hsu, Stimson P. Schantz

   Pages 31-34

6. Alcohol: A Cocarcinogen in Head and Neck Malignancies

   • T. C. Hsu

   Pages 35-37

7. Smokeless Tobacco and Aerodigestive Tract Cancers: Recent Research Directions

   • Deborah M. Winn

   Pages 39-46

8. Biologic Markers as Predictors of Risk in Aerodigestive Tract Cancers

   • Bruce Trock

   Pages 47-54

9. Hamster Lung Cancer Model of Carcinogenesis and Chemoprevention

   • Richard C. Moon, Kandala V. N. Rao, Carol J. Detrisac, Gary J. Kelloff

   Pages 55-61

10. The Hamster Cheek Pouch Model of Carcinogenesis and Chemoprevention

    • Irma B. Gimenez-Conti, Thomas J. Slaga

    Pages 63-67

11. Culture Conditions Affect Expression of the α6β4 Integrin Associated with Aggressive Behavior in Head and Neck Cancer

    • Thomas E. Carey, Leena Laurikainen, Angelika Ptok, Timothy Reinke, Keith Linder, Thankam S. Nair et al.

    Pages 69-79

12. Growth Factors and Other Targets for Rational Application as Intervention Agents

    • James L. Mulshine, Michael Birrer, Anthony M. Treston, Frank Scott, Kathryn Quinn, Ingalill Avis et al.

    Pages 81-88

13. Hyperplasia and Squamous Metaplasia in the Tracheobronchial Epithelium: Alterations in the Balance of Growth and Differentiation Factors

    • Anton M. Jetten, Thomas M. Vollberg, Clara Nervi

    Pages 89-93

14. Micronuclei as Intermediate End Points in Intervention

    • Miriam P. Rosin

    Pages 95-104

15. Study Design for the Prevention of Aerodigestive Tract Cancers

    • Thomas E. Moon

    Pages 105-109

16. Participant Enrollment, Participation, and Compliance in Chemoprevention Trials

    • Barbara K. Rimer

    Pages 111-117

17. A Population-based Trial of β-Carotene Chemoprevention of Head and Neck Cancer

    • Susan Taylor Mayne, Tongzhang Zheng, Dwight T. Janerich, W. Jarrard Goodwin Jr., Barbara G. Fallon, Dennis L. Cooper et al.

    Pages 119-127

18. Chemoprevention of Barrett’s Esophagus and Oral Leukoplakia

    • Harinder S. Garewal

    Pages 129-136

19. Carotene and Retinol Efficacy Trial: Lung Cancer Chemoprevention Trial in Heavy Cigarette Smokers and Asbestos-exposed Workers

    • Gary E. Goodman, Gilbert S. Omenn, CARET Coinvestigators and Staff

    Pages 137-140

20. An Intervention Trial in High-Risk Asbestos-exposed Persons

    • Jerry W. McLarty

    Pages 141-149

The papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, "The Biology and Prevention of Aerodigestive Tract Cancers," sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under­ standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcinogenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phenomena described as "field cancerization. " This process contributes to the development of both synchronous and metachronous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcinogen­ esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagnosed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.

• cancer
• cancer prevention
• carcinogenesis
• carcinoma
• epidemiology
• esophagus
• etiology
• lung cancer
• prevention

• The University of Texas M. D. Anderson Cancer Center, Houston, USA

  Guy R. Newell, Waun Ki Hong

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