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Boron Neutron Capture Therapy

Toward Clinical Trials of Glioma Treatment

  • Book
  • © 1992

Overview

Editors:
  1. Detlef Gabel

    1. University of Bremen, Bremen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  2. Ray Moss

    1. Joint Research Centre, Petten, The Netherlands

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    You can also search for this editor in PubMed   Google Scholar

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Table of contents (27 chapters)

  1. Front Matter

    Pages i-ix
    Download chapter PDF

  2. Opening Speech

    • E. D. Hondros
    Pages 1-3

  3. Welcome Address

    • H. H. van den Kroonenberg
    Pages 5-6

  4. Safety and Efficacy in Boron Neutron Capture Therapy

    • Detlef Gabel
    Pages 7-13

  5. Some Aspects of BNCT Research at the Brookhaven National Laboratory

    • Darrel D. Joel, Vili Benary, Robert M. Brugger, Jeffrey A. Coderre
    Pages 15-22

  6. INEL BNCT Program Directions with Respect to Clinical Trials of BNCT

    • Ronald V. Dorn III
    Pages 23-27

  7. The Department of Energy Research Program in Boron Neutron Capture Therapy

    • Robert W. Wood, Donald W. Cole Jr.
    Pages 29-31

  8. Current Overview on the Approach of Clinical Trials at Petten

    • Raymond L. Moss
    Pages 33-46

  9. Review of the Physics Calculations Performed for the BNCT Facility at the HFR Petten

    • Peter Watkins, Mark Konijnenberg, Geoffrey Constantine, Herbert Rief, R. Ricchena, Johan B. M. de Haas et al.
    Pages 47-58

  10. From Filter Installation to Beam Characterization

    • Finn Stecher-Rasmussen, Geoff Constantine, Willi Freudenreich, Han de Haas, Raymond L. Moss, Ardi Paardekooper et al.
    Pages 59-77

  11. Neutron Spectrometry Measurements of the Petten HFR, HB11 Neutron Beam

    • Christopher A. Perks, Howard J. Delafield
    Pages 79-91

  12. A Semi-Empirical Method of Treatment Planning for Boron Neutron Capture Therapy

    • Cornelis P. J. Raaijmakers, Luc Dewit, Mark W. Konijnenberg, Ben J. Mijnheer, Raymond L. Moss, Finn Stecher-Rasmussen
    Pages 93-100

  13. Present Status of the Three-Dimensional Treatment Planning Methodologies for the Petten BNCT Facility

    • Peter Watkins
    Pages 101-109

  14. A Phase 1 Biodistribution Study of p-Boronophenylalanine

    • Jeffrey A. Coderre
    Pages 111-121

  15. RBE in Normal Tissue Studies

    • Reinhard A. Gahbauer, Ralph G. Fairchild, Joseph H. Goodman, Thomas E. Blue
    Pages 123-128

  16. Treatment Planning and Optimization for Pion Therapy

    • Hans Blattmann
    Pages 129-141

  17. Dose Calculations Based on Image Reconstructions

    • Floyd J. Wheeler, Daniel E. Wessol
    Pages 143-154

  18. Borocaptate Sodium (BSH) Pharmacokinetics in Glioma Patients

    • Heinz Fankhauser, Giuseppe Stragliotto, Pascal Zbinden
    Pages 155-162

  19. BSH in Patients with Malignant Glioma: Distribution in Tissues, Comparison Between BSH Concentration and Histology

    • Dietrich Haritz, Detlef Gabel, Harold Klein, René Huiskamp, Orn-Anong Pettersson
    Pages 163-174

  20. Macroscopic and Microscopic Biodistribution of BSH in a Rat Glioma Model

    • Crister P. Ceberg, Anders Persson, Arne Brun, Bengt Jergil, Bertil R. R. Persson, Leif G. Salford
    Pages 175-178
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Keywords

About this book

The European Collaboration on Boron Neutron Capture Therapy (BNCT), conceived in 1987 and successful in 1989 in gaining financial support as a Concerted Action through the Medical and Health Research Programme of the Commission ofthe European Communities (CEC) in Brussels, considered it an opportune moment to hold its annual Plenary Meeting on 18-20 Septem­ ber 1991 as an International Workshop entitled "Towards Clinical Trials of Glioma with BNCT". The background to this consideration was influenced by the world-wide resurgence ofinterest in NCT over the last 2 decades and by the exemplifica­ tions at the Fourth International Symposium on Neutron Capture Therapy for Cancer held in Sydney in December 1990, where it was strongly indicated that within the next 2 years clinical trials would be started both in Europe and the United States. In particular at the High Flux Reactor of the Joint Research Centre of the CEC at Petten in The Netherlands, an epithermal neutron beam designed and installed in the summer of 1990 recently became operable at full reactor power. An extensive series ofexperiments, including the nuclear and radiobiological characterisation of the beam and a healthy tissue tolerance study on canines has started and has the aim to define the preconditions for clinical trials onpatients with Grade III/IV glioma. However, as with any other new therapy modality, it must be demon­ strated that BNCT is safe for the patient and has a reasonable chance of being an effective therapy.

Editors and Affiliations

  • University of Bremen, Bremen, Germany

    Detlef Gabel

  • Joint Research Centre, Petten, The Netherlands

    Ray Moss

Bibliographic Information

  • Book Title: Boron Neutron Capture Therapy

  • Book Subtitle: Toward Clinical Trials of Glioma Treatment

  • Editors: Detlef Gabel, Ray Moss

  • DOI: https://doi.org/10.1007/978-1-4615-3408-2

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1992

  • Hardcover ISBN: 978-0-306-44350-3Published: 31 January 1993

  • Softcover ISBN: 978-1-4613-6506-8Published: 26 October 2012

  • eBook ISBN: 978-1-4615-3408-2Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: IX, 279

  • Topics: Oncology, Pharmacology/Toxicology, Nuclear Medicine, Ultrasound

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